Revisiting familial aggregation of prostate cancer within the 3D framework of genetics-epigenetics-environment [0.03%]
基于遗传学-表观遗传学-环境三维框架重新审视前列腺癌的家族聚集性
Kunshan Shi,Baotai Liang,Ting He et al.
Kunshan Shi et al.
Prostate cancer (PCa) is one of the most heritable cancers, exhibiting significant familial aggregation, however, its underlying mechanisms remain incompletely understood. This review proposes a Genetics-Epigenetics-Environment (G-E-E) 3D f...
Somatic variant-calling beyond cancer: Repurposing algorithms to map low‑allele‑fraction variants across genomics [0.03%]
超越癌症的体细胞变异检测：重新利用算法以绘制低等位基因分数变异的全貌
Nicholas Taylor,Timothy J Hearn
Nicholas Taylor
Background: Somatic variant callers were originally developed to identify tumour-specific mutations in mixed tumour-normal samples. Increasingly, disciplines such as developmental biology, reproductive medicine, virology ...
The comet assay as a tool for human biomonitoring of exposure to environmental and occupational agents - a summary of systematic reviews and meta-analyses [0.03%]
彗星试验作为环境和职业暴露的人体生物监测工具——系统评价和meta分析的总结报告
Peter Møller,Goran Gajski,Marko Gerić et al.
Peter Møller et al.
This paper compiles results from six systematic reviews and meta-analyses on associations between environmental and occupational exposure to chemicals and levels of DNA strand breaks in human leukocytes, measured by the comet assay. There a...
Genomic instability in canine mammary tumors: A comparative focus on loss of heterozygosity and microsatellite alterations with human breast cancer [0.03%]
犬乳腺肿瘤的基因组不稳定性：与人类乳腺癌异源合子丢失和微卫星变异的比较重点
Faiz Muhammad Khand,Barkat Ali Jatoi,Shakeel Ahmed Lakho et al.
Faiz Muhammad Khand et al.
Canine mammary tumors (CMTs) are the most prevalent neoplasms in intact female dogs, accounting for up to 50% of all neoplasms, with malignancy rates ranging from 50% to 89%. Human breast cancer (HBC) remains a leading cause of cancer morbi...
Mutations in a-kinase anchoring protein 9 disrupt β-adrenergic modulation of delayed rectifier potassium current in long QT syndrome [0.03%]
长QT综合症中锚蛋白9的突变影响β肾上腺素能对延迟整流钾电流的调节作用
Huan Yuan,Lin Lu,Hu Wen et al.
Huan Yuan et al.
Inherited long QT syndrome (LQTS) is a life-threatening cardiac channelopathy characterized by impaired ventricular repolarization and heightened susceptibility to ventricular arrhythmias and sudden cardiac death. While mutations in ion cha...
A comprehensive review of variant calling tools for RNA-seq: Challenges and advances [0.03%]
全面综述RNA序变异呼叫工具：挑战与进展
Sarita Maurya,Chakresh Kumar Jain
Sarita Maurya
RNA sequencing (RNA-seq) has become a powerful technology for capturing transcriptomic variation, enabling the detection of expressed genetic variants that influence gene regulation, disease mechanisms, and therapeutic response. Unlike DNA ...
The comet assay as a tool in human biomonitoring exposure to antineoplastic drugs - A systematic review and meta-analysis [0.03%]
彗星试验作为人类生物监测抗肿瘤药物暴露的工具-系统评价和Meta分析
Carina Ladeira,Amaya Azqueta,Lisa Giovannelli et al.
Carina Ladeira et al.
Antineoplastic agents are toxic compounds, generally used in the treatment of cancers, which are recognized as carrying a cancer development risk. In this systematic review and meta-analysis of human biomonitoring studies, we have assessed ...
PCR based site-directed mutagenesis: An extensively used tool for the functional genomics studies in begomoviruses [0.03%]
基于PCR的定点突变：一种在 begomovirus 功能基因组研究中广泛应用的技术
Gnanaprakash Jeyaraj,Alok Kumar,A Swapna Geetanjali
Gnanaprakash Jeyaraj
Site-directed mutagenesis (SDM) is an important tool that allows the quick and efficient manipulations of specific residues in DNA sequences for investigating their importance in structure and function of proteins. Out of several techniques...
Roles and clinical implications of N6-methyladenosine in digestive system tumors [0.03%]
N6-甲基腺苷在消化系统肿瘤中的作用及临床意义
Shixin Luo,Lusheng Liu,Min Sun et al.
Shixin Luo et al.
Digestive system tumors such as gastric, colorectal, esophageal, hepatocellular, pancreatic and gallbladder cancers are a huge global health burden, featuring high incidence, high malignancy, difficult early diagnosis and poor prognosis. Id...
Mitochondrial DNA: Bridging cellular senescence and chronic inflammation in aging and beyond [0.03%]
线粒体DNA：连接细胞衰老与慢性炎症的桥梁作用及其在长寿中的意义
Shimeng Wang,Fanglong Wu,Hongmei Zhou
Shimeng Wang
Aging is a progressive and irreversible physiological process driven by a complex network of interrelated molecular and cellular mechanisms. Among these, cellular senescence and chronic inflammation, as two core hallmarks of aging, are inte...