Recently Published Patents on Janus Base Nanomaterials for RNA Delivery [0.03%]
近期关于用于RNA递送的Janus基纳米材料的专利发布
Wuxia Zhang,Yupeng Chen
Wuxia Zhang
Domino/Cascade and Multicomponent Reactions for the Synthesis of Thiazole Derivatives [0.03%]
叠氮-炔、串联和多组分反应合成噻唑类衍生物研究进展
Mohammad A Alam
Mohammad A Alam
Substituted thiazoles are widely known as natural products, approved drugs, and a number of synthetic compounds as bioactive agents. Due to the worth of this heterocycle nucleus, a large number of synthetic methodologies have been reported ...
Mohammad A Alam
Mohammad A Alam
Substituted hydroxamic acid is one of the most extensively studied pharmacophores because of their ability to chelate biologically important metal ions to modulate various enzymes, such as HDACs, urease, metallopeptidase, and carbonic anhyd...
Isoflavones, their Glycosides and Glycoconjugates. Synthesis and Biological Activity [0.03%]
异黄酮、苷和糖结合物的合成与生物活性
Wiesław Szeja,Grzegorz Grynkiewicz,Aleksandra Rusin
Wiesław Szeja
Glycosylation of small biologically active molecules, either of natural or synthetic origin, has a profound impact on their solubility, stability, and bioactivity, making glycoconjugates attractive compounds as therapeutic agents or nutrace...
Carbon Dioxide Utilization by the Five-Membered Ring Products of Cyclometalation Reactions [0.03%]
环金属化反应五元环产物的二氧化碳活化性能研究
Iwao Omae
Iwao Omae
In carbon dioxide utilization by cyclometalated five-membered ring products, the following compounds are used in four types of applications: 1. 2-Phenylpyrazole iridium compounds, pincer phosphine iridium compounds and 2-phenylimidazoline i...
Dimitrios Priftis
Dimitrios Priftis
Due to their unique structure, the optical and mechanical properties graphene and its derivatives (e.g. graphene oxide, reduced graphene oxide) have captured the attention of a constantly increasing number of scientists with regards to biom...
Strategies and Methods for the Synthesis of Anticancer Natural Product Neopeltolide and its Analogs [0.03%]
抗癌天然产物Neopeltolide及其类似物的合成策略与方法学研究
Yu Bai,Mingji Dai
Yu Bai
Neopeltolide, isolated in 2007, with its novel structural features and potent anti cancer cell proliferation activity, has attracted a tremendous amount of synthetic efforts. This review briefly and chronologically summarizes each of the sy...
Brian Creran,Uwe H F Bunz,Vincent M Rotello
Brian Creran
Sensing clinically relevant biomolecules is crucial for the detection and prevention of disease. Currently used detection methods tend to be expensive, time intensive, and specific for only one particular biomolecule of interest. Nanopartic...
Quinone Methide Bioactivation Pathway: Contribution to Toxicity and/or Cytoprotection? [0.03%]
苯甲酮代谢活化途径：对毒性及细胞保护的贡献？
Judy L Bolton
Judy L Bolton
The formation of quinone methides (QMs) from either direct 2-electron oxidation of 2- or 4-alkylphenols, isomerization of o-quinones, or elimination of a good leaving group could explain the cytotoxic/cytoprotective effects of several drugs...
Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids [0.03%]
甲基赤藓糖醇磷酸途径中间体及下游异戊二烯类化合物的合成路线
Sarah K Jarchow-Choy,Andrew T Koppisch,David T Fox
Sarah K Jarchow-Choy
Isoprenoids constitute the largest class of natural products with greater than 55,000 identified members. They play essential roles in maintaining proper cellular function leading to maintenance of human health, plant defense mechanisms aga...