Global gene expression profiling of human osteosarcomas reveals metastasis-associated chemokine pattern [0.03%]
人骨肉瘤的全球基因表达谱分析发现与转移相关的细胞因子模式
Heidi M Namløs,Stine H Kresse,Christoph R Müller et al.
Heidi M Namløs et al.
Global gene expression analysis was performed on a panel of 23 osteosarcoma samples of primary and metastatic origin using the Applied Biosystems Gene Expression Array System. When comparing the primary tumours with the metastases, we found...
Eivind Smeland,Thomas K Kilvaer,Sveinung Sorbye et al.
Eivind Smeland et al.
Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissu...
Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma [0.03%]
去分化软骨肉瘤肺转移潜在多功能标志物
Sergey Malchenko,Elisabeth A Seftor,Yuri Nikolsky et al.
Sergey Malchenko et al.
Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this pap...
Kosei Ando,Kanji Mori,Franck Verrecchia et al.
Kosei Ando et al.
Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases which is the main cause of death. Unfortunately, the conventional chemotherapy is not fully effective on osteosarcoma met...
Maurice Balke,Marcel P Henrichs,Georg Gosheger et al.
Maurice Balke et al.
Background. We report on 19 cases of giant cell tumor of bone (GCT) affecting the spine or sacrum and evaluate the outcome of different treatment modalities. Methods. Nineteen patients with GCT of the spine (n = 6) or sacrum (n = 13) have b...
Classification, molecular characterization, and the significance of pten alteration in leiomyosarcoma [0.03%]
平滑肌肉瘤的分类、分子特征及PTEN改变的意义
Allie H Grossmann,Lester J Layfield,R Lor Randall
Allie H Grossmann
Leiomyosarcoma is a malignant smooth muscle neoplasm with a complicated histopathologic classification scheme and marked differences in clinical behavior depending on the anatomic site of origin. Overlapping morphologic features of benign a...
STAT3 Regulates Proliferation and Immunogenicity of the Ewing Family of Tumors In Vitro [0.03%]
STAT3调控尤因肉瘤体外增殖和免疫原性
Sam Behjati,B Piku Basu,Rebecca Wallace et al.
Sam Behjati et al.
The Ewing sarcoma family of tumors (ESFT) represents an aggressive spectrum of malignant tumour types with common defining histological and cytogenetic features. To evaluate the functional activation of signal transducer and activator of tr...
Simone Fulda
Simone Fulda
Resistance of rhabdomyosarcoma to current therapies remains one of the key issues in pediatric oncology. Since the success of most cytotoxic therapies in the treatment of cancer, for example, chemotherapy, depends on intact signaling pathwa...
Prognostic factors and metastatic patterns in primary myxoid/round-cell liposarcoma [0.03%]
黏液样/圆细胞脂肪肉瘤的预后因素和转移规律
J Haniball,V P Sumathi,L-G Kindblom et al.
J Haniball et al.
Background. This study aimed to investigate prognostic factors for patients with myxoid/round-cell liposarcoma (MRCLS), in particular the significance of the round cell component, and to identify metastatic patterns as well as possibly sugg...
Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience [0.03%]
轴向骨骼部位是尤因肉瘤预后不良的预测因素：单中心经验报告
Kurt R Weiss,David J Biau,Rej Bhumbra et al.
Kurt R Weiss et al.
Introduction. Ewing's sarcomas (EWSs) of bone and soft tissue are neuroectodermal tumors that affect both axial and appendicular locations. We hypothesized that axial location predicted poor outcome in EWS patients. Materials and Methods. S...