MAPK/ERK Signaling in Osteosarcomas, Ewing Sarcomas and Chondrosarcomas: Therapeutic Implications and Future Directions [0.03%]
骨肉瘤、尤因肉瘤和软骨肉瘤中的MAPK/ERK信号转导：治疗意义及未来方向
Chandhanarat Chandhanayingyong,Yuhree Kim,J Robert Staples et al.
Chandhanarat Chandhanayingyong et al.
The introduction of cytotoxic chemotherapeutic drugs in the 1970's improved the survival rate of patients with bone sarcomas and allowed limb salvage surgeries. However, since the turn of the century, survival data has plateaued for a subse...
Nicolas Penel,Eric Yaovi Amela,Gauthier Decanter et al.
Nicolas Penel et al.
We have reviewed the literature data regarding the spectrum of tumors including solitary fibrous tumor and hemangiopericytoma with special focus on definition of the disease, discussion of the criteria for malignancy, and the key elements o...
Alveolar soft part sarcomas: molecular pathogenesis and implications for novel targeted therapies [0.03%]
肺泡软部组织肉瘤：分子病理发生学和新型靶向治疗的启示
Bryan Mitton,Noah Federman
Bryan Mitton
Alveolar soft part sarcoma (ASPS) is a very rare soft tissue sarcoma which arises primarily in children and young adults. Despite its unique histology and well-characterized genetic translocation, many questions remain regarding the pathoge...
Alexander B Mohseny,Pancras C W Hogendoorn,Anne-Marie Cleton-Jansen
Alexander B Mohseny
High-grade osteosarcoma is an aggressive tumor most commonly affecting adolescents. The early age of onset might suggest genetic predisposition; however, the vast majority of the tumors are sporadic. Early onset, most often lack of a predis...
Incidence and survival of pediatric soft tissue sarcomas in moscow region, Russian Federation, 2000-2009 [0.03%]
俄罗斯联邦莫斯科地区2000-2009年儿童软组织肉瘤的发病率和生存率
D Y Kachanov,K V Dobrenkov,R T Abdullaev et al.
D Y Kachanov et al.
The aim of the study was to assess the incidence and survival rates of soft tissue sarcomas (STSs) in children 0-14 years of age in Moscow Region, Russian Federation. The database of childhood population-based cancer registry of Moscow Regi...
Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma? [0.03%]
所有转移性或盆腔尤文氏肉瘤患者都要力求积极的手术局部控制吗？
Steven W Thorpe,Kurt R Weiss,Mark A Goodman et al.
Steven W Thorpe et al.
In previous reports, patients with Ewing's sarcoma received radiation therapy (XRT) for definitive local control because metastatic disease and pelvic location were thought to preclude aggressive local treatment. We sought to determine if s...
Lars M Wagner,Teresa A Smolarek,Janos Sumegi et al.
Lars M Wagner et al.
Advances in molecular pathology now allow for identification of rare tumor cells in cancer patients. Identification of this minimal residual disease is particularly relevant for Ewing sarcoma, given the potential for recurrence even after c...
Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study [0.03%]
转移性软组织肉瘤和骨肉瘤患者的生存质量及效用：来自北美洲和欧洲的关于肉瘤治疗与疾病负担的研究(SABINE研究)
Peter Reichardt,Michael Leahy,Xavier Garcia Del Muro et al.
Peter Reichardt et al.
The aim of the study was to assess health-related quality of life (HRQoL) among metastatic soft tissue (mSTS) or bone sarcoma (mBS) patients who had attained a favourable response to chemotherapy. We employed the EORTC QLQ-C30, the 3-item C...
Desmoplastic small round cell tumor: current management and recent findings [0.03%]
间叶样小圆细胞瘤的目前治疗及最新研究动态
Armelle Dufresne,Philippe Cassier,Laure Couraud et al.
Armelle Dufresne et al.
Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive mesenchymal tumor that develops in the abdominal cavity of young men adults. Patients typically present with symptoms of abdominal sarcomatosis. Diagnosis is based ...
A meta-analysis of osteosarcoma outcomes in the modern medical era [0.03%]
现代医学时代的骨肉瘤结局的meta分析研究论文题目
Daniel C Allison,Scott C Carney,Elke R Ahlmann et al.
Daniel C Allison et al.
Four decades ago, specialized chemotherapy regimens turned osteosarcoma, once considered a uniformly fatal disease, into a disease in which a majority of patients survive. Though significant survival gains were made from the 1960s to the 19...