Myrthe P P van Herk-Sukel,Sumitra Shantakumar,Lucy I H Overbeek et al.
Myrthe P P van Herk-Sukel et al.
Background. Data is limited on the burden of common comorbidities, such as cardiovascular disease (CVD), respiratory disease and diabetes, or comorbidities related to cancer and its treatment, such as anemia and depression, in patients with...
Jeff W Martin,Jeremy A Squire,Maria Zielenska
Jeff W Martin
Osteosarcoma is a primary bone malignancy with a particularly high incidence rate in children and adolescents relative to other age groups. The etiology of this often aggressive cancer is currently unknown, because complicated structural an...
Alveolar soft part sarcoma: a single-center 26-patient case series and review of the literature [0.03%]
肺泡软部组织肉瘤：单中心26例报告和文献复习
Koichi Ogura,Yasuo Beppu,Hirokazu Chuman et al.
Koichi Ogura et al.
Background. Alveolar soft part sarcoma (ASPS) is a rare tumor, and little information is available regarding its clinical features and appropriate treatments. Methods. A retrospective review of 26 consecutive ASPS patients (12 male, 14 fema...
The molecular biology of soft-tissue sarcomas and current trends in therapy [0.03%]
软组织肉瘤的分子生物学和当前治疗趋势
Jorge Quesada,Robert Amato
Jorge Quesada
Basic research in sarcoma models has been fundamental in the discovery of scientific milestones leading to a better understanding of the molecular biology of cancer. Yet, clinical research in sarcoma has lagged behind other cancers because ...
Matteo Trucco,David Loeb
Matteo Trucco
Sarcomas represent a heterogeneous group of cancers thought to originate from malignant transformation of mesenchymal cells. There is increasing evidence that many, if not all, sarcomas contain within them tumor-initiating, or "cancer stem,...
rAAV Vectors as Safe and Efficient Tools for the Stable Delivery of Genes to Primary Human Chondrosarcoma Cells In Vitro and In Situ [0.03%]
基于人软骨肉瘤原代细胞的腺相关病毒载体的基因治疗研究
Henning Madry,Jagadeesh K Venkatesan,Gertrud Schmitt et al.
Henning Madry et al.
Treatment of chondrosarcoma remains a major challenge in orthopaedic oncology. Gene transfer strategies based on recombinant adenoassociated viral (rAAV) vectors may provide powerful tools to develop new, efficient therapeutic options again...
Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma [0.03%]
磷脂酰肌醇-3激酶抑制剂在未分化的多形性肉瘤原代小鼠模型中疗效的研究
Suzy Kim,Rebecca D Dodd,Jeffrey K Mito et al.
Suzy Kim et al.
Recent advances in sarcoma genomics have identified novel mutations in the PI3K pathway in human sarcomas. Here, we use a mouse model of primary soft-tissue sarcoma for preclinical testing of doxorubicin and inhibitors of the PI3K pathway: ...
Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330 [0.03%]
与沙利度胺及多模式治疗软组织肉瘤相关的血栓事件：RTOG 0330试验结果
J M Kane rd,J Harris,W G Kraybill et al.
J M Kane rd et al.
Introduction. RTOG 0330 was developed to address the toxicity of RTOG 9514 and to add thalidomide (THAL) to MAID chemoradiation for intermediate/high grade soft tissue sarcomas (STSs) and to preoperative radiation (XRT) for low-grade STS. M...
"Malignant" perivascular epithelioid cell neoplasm: risk stratification and treatment strategies [0.03%]
恶性血管周上皮样细胞瘤的风险分层和治疗策略
Jonathan S Bleeker,J Fernando Quevedo,Andrew L Folpe
Jonathan S Bleeker
Purpose. Perivascular epithelioid cell tumors (PEComas) are a rare collection of tumors characterized by a myomelanocytic phenotype, and PEComas occurring in "nonclassic" anatomic distributions are known as perivascular epithelioid cell tum...
Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting [0.03%]
胚胎信号通路与横纹肌肉瘤：对肿瘤发生和发展的影响以及治疗靶点的发现
Brian Belyea,Julie Grondin Kephart,Jordan Blum et al.
Brian Belyea et al.
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence, accounting for approximately 7% of childhood cancers. Current therapies include nonspecific cytotoxic chemotherapy regimens, radiation therapy, and surger...