The role of chemokine receptor CXCR4 in the biologic behavior of human soft tissue sarcoma [0.03%]
趋化因子受体CXCR4在人类软组织肉瘤生物学行为中的作用
Roger H Kim,Benjamin D L Li,Quyen D Chu
Roger H Kim
The molecular basis of sarcoma remains poorly understood. However, recent studies have begun to uncover some of the molecular pathways involved in sarcomagenesis. The chemokine receptor CXCR4 has been implicated in sarcoma development and h...
Surmounting chemotherapy and radioresistance in chondrosarcoma: molecular mechanisms and therapeutic targets [0.03%]
软骨肉瘤化疗和放疗耐药的分子机制及治疗靶点
Anne C Onishi,Alexander M Hincker,Francis Y Lee
Anne C Onishi
Chondrosarcoma, a primary malignancy of bone, has eluded successful treatment with modern chemotherapeutic and radiation regimens. To date, surgical resection of these tumors remains the only curative treatment offered to patients with this...
Impairment of methotrexate transport is common in osteosarcoma tumor samples [0.03%]
骨肉瘤标本中甲氨蝶呤转运障碍很常见
Rebecca Sowers,Bethanne D Wenzel,Condon Richardson et al.
Rebecca Sowers et al.
Osteosarcoma does not respond well to conventional dose methotrexate but does respond to high-dose methotrexate. Previous work has indicated that this resistance may be due to impaired transport of methotrexate across the cell membrane. In ...
Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family [0.03%]
简述FUS/EWS/TAF15蛋白家族的双重面貎
Heinrich Kovar
Heinrich Kovar
FUS, EWS, and TAF15 form the FET family of RNA-binding proteins whose genes are found rearranged with various transcription factor genes predominantly in sarcomas and in rare hematopoietic and epithelial cancers. The resulting fusion gene p...
Paul M Neilsen,Kathleen I Pishas,David F Callen et al.
Paul M Neilsen et al.
The p53 tumour suppressor plays a pivotal role in the prevention of oncogenic transformation. Cancers frequently evade the potent antitumour surveillance mechanisms of p53 through mutation of the TP53 gene, with approximately 50% of all hum...
Hemant K Bid,Peter J Houghton
Hemant K Bid
Angiogenesis and vasculogenesis constitute two processes in the formation of new blood vessels and are essential for progression of solid tumors. Consequently, targeting angiogenesis, and to a lesser extent vasculogenesis, has become a majo...
J W Martin,M Zielenska,G S Stein et al.
J W Martin et al.
Osteosarcoma is an aggressive but ill-understood cancer of bone that predominantly affects adolescents. Its rarity and biological heterogeneity have limited studies of its molecular basis. In recent years, an important role has emerged for ...
Timothy P Cripe
Timothy P Cripe
Ewing sarcoma was named after James R. Ewing, an eminent American pathologist at Cornell who described the first cases in 1921. Although he is best remembered for this singular achievement, Ewing's contributions to the study of cancer were ...
Current therapeutic approaches in metastatic and recurrent ewing sarcoma [0.03%]
Ewing肉瘤转移和复发的当前治疗方法
Michael Huang,Kenneth Lucas
Michael Huang
Ewing sarcoma (ES) is the second most common type of primary bone malignancy in children and young adults. Survival rates for localized ES have improved to upwards of 70% with aggressive chemotherapy and local control. On the other hand, th...
Pierre-Louis Docquier,Laurent Paul,Olivier Cartiaux et al.
Pierre-Louis Docquier et al.
Pelvic sarcoma is associated with a relatively poor prognosis, due to the difficulty in obtaining an adequate surgical margin given the complex pelvic anatomy. Magnetic resonance imaging and computerized tomography allow valuable surgical r...