Mi-Jung Kim,Kyung-Ja Cho,Alberto G Ayala et al.
Mi-Jung Kim et al.
Chondrosarcoma (CHS) is a malignant cartilage-forming tumor and usually occurs within the medullary canal of long bones and pelvic bones. Based on the morphologic feature alone, a correct diangosis of CHS may be difficult, Therefore, correl...
A"Proteoglycan targeting strategy" for the scintigraphic imaging and monitoring of the swarm rat chondrosarcoma orthotopic model [0.03%]
一种用于扫描成像和监测群聚鼠软骨肉瘤原位移植模型的蛋白质糖链靶向策略
Caroline Peyrode,François Gouin,Aurélien Vidal et al.
Caroline Peyrode et al.
Our lab developed (99m)Tc-NTP 15-5 radiotracer as targeting proteoglycans (PGs) for the scintigraphic imaging of joint. This paper reports preclinical results of (99m)Tc-NTP 15-5 imaging of an orthotopic model of Swarm rat chondrosarcoma (S...
Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival [0.03%]
血小板源性生长因子在非GIST软组织肉瘤中识别出一类伴有广泛切除边缘和较差肿瘤特异性生存率的患者群体
Thomas Karsten Kilvaer,Andrej Valkov,Sveinung W Sorbye et al.
Thomas Karsten Kilvaer et al.
Background. Optimal treatment of nongastrointestinal stromal tumor soft-tissue sarcomas (non-GIST STSs) is resection with wide margins. This study investigates the prognostic impact of the angiogenesis-associated platelet-derived growth fac...
Seth M Pollack,Elizabeth T Loggers,Eve T Rodler et al.
Seth M Pollack et al.
Immunotherapy has shown promise in a number of tumor types, but its exact role in sarcoma remains to be defined. Advanced bone and soft tissue sarcomas are challenging diseases to treat with an unmet need for effective systemic therapy. Pre...
Rachel Conyers,Sophie Young,David M Thomas
Rachel Conyers
Sarcomas are a group of heterogeneous tumours with varying genetic basis. Cytogenetic abnormalities range from distinct genomic rearrangements such as pathognomonic translocation events and common chromosomal amplification or loss, to more ...
Involvement of the soluble urokinase receptor in chondrosarcoma cell mobilization [0.03%]
可溶性urokinase受体在软骨肉瘤细胞动员中的作用
Katia Bifulco,Immacolata Longanesi-Cattani,Maria Teresa Masucci et al.
Katia Bifulco et al.
High levels of urokinase receptor (uPAR) in tissue and serum of patients with chondrosarcoma correlate with poor prognosis. First, we analyzed the uPAR levels in tissues and plasma of five patients affected by chondrosarcoma. Interestingly,...
Krithi Rao-Bindal,Eugenie S Kleinerman
Krithi Rao-Bindal
The role of genetic mutations in the development of osteosarcoma, such as alterations in p53 and Rb, is well understood. However, the significance of epigenetic mechanisms in the progression of osteosarcoma remains unclear and is increasing...
Silke Brüderlein,Joshua B Sommer,Paul S Meltzer et al.
Silke Brüderlein et al.
Immortal tumor cell lines are an important model system for cancer research, however, misidentification and cross-contamination of cell lines are a common problem. Seven chordoma cell lines are reported in the literature, but none has been ...
Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma [0.03%]
血小板衍生生长因子受体作为横纹肌肉瘤治疗靶点的作用
Lisa E S Crose,Corinne M Linardic
Lisa E S Crose
Rhabdomyosarcomas (RMSs) are the most common soft tissue sarcomas of childhood and adolescence. To date, there are no effective treatments that target the genetic abnormalities in RMS, and current treatment options for high-risk groups are ...
Robert Grimer,Nick Athanasou,Craig Gerrand et al.
Robert Grimer et al.
These guidelines have been developed in order to provide an overview and a set of broad-based key recommendations for the management of patients with bone sarcomas in the UK. They have taken into consideration the most up-to-date scientific...