Durable platelet response and immature platelet indices following sequential efgartigimod and eltrombopag therapy in a patient with refractory ITP [0.03%]
难治性ITP患者序贯使用Efgartigimod和Eltrombopag治疗后的持久血小板反应及未成熟血小板指标变化
Fumiya Wada,Hiroyuki Matsui,Takuji Nakamura et al.
Fumiya Wada et al.
Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, represents a novel therapeutic approach for refractory immune thrombocytopenia (ITP). However, its clinical positioning and durability of response in real-world settings remain unclear...
Lih T Cheah,Jawad S Khalil,Beth A Webb et al.
Lih T Cheah et al.
Platelet activation is energy-dependent and associated with a hyperglycolytic phenotype, yet the role of key glycolytic enzymes remains unclear. We investigated the role of platelet hexokinases (HK1 and HK2) in regulating thrombin- and conv...
Chemiluminescence resonance energy transfer-based method to investigate the platelet surface molecule in acute myocardial infarction [0.03%]
基于化学发光共振能量转移技术检测急性心梗患者血小板表面分子的方法学研究
Linyan He,Bing Ding,Fei Shen et al.
Linyan He et al.
The chemiluminescence resonance energy transfer (CRET)-based method was applied to the detect of CD61 and CD62P (P-selectin) on the surface of platelet in patients with acute myocardial infarction (AMI) and healthy controls. Patients admitt...
Alexandre Slater,Hsin-Yun Pan,Tz-Han Ho et al.
Alexandre Slater et al.
Platelet spreading assays are widely used to assess platelet adhesion, cytoskeletal remodeling and receptor‑specific signaling, but current GPVI ligands such as Collagen Related Peptide (CRP‑XL) suffer from non‑defined structure, batch v...
Neural network reveals platelet age from fluorescence microscopy images [0.03%]
基于荧光显微图像的神经网络揭示血小板年龄
Johan A Slotman,Maurice Swinkels,Sophie Hordijk et al.
Johan A Slotman et al.
Platelets are small, anucleate cells with a primary physiological role in vascular damage repair (hemostasis) and initiation of thrombus formation in response to vascular injury. Platelets circulate approximately 7-10 days, slowly undergoin...
Jillian Teichman,Andrew D Johnson
Jillian Teichman
Studies investigating the role of differential platelet function across various ancestry groups have been ongoing since at least the middle twentieth century. Consistently identified trends include differential frequency of CD36 deficiencie...
Platelet-rich plasma concentrations regulate MSCs osteogenesis via MAPK/PI3K-AKT pathways to mitigate inflammatory bone loss [0.03%]
富血小板血浆浓度通过MAPK/PI3K-Akt通路调节间充质干细胞成骨作用从而缓解炎性骨丢失
Shaochuan Wang,Debin Guo,Shidan Li et al.
Shaochuan Wang et al.
Bone maintains a dynamic and stable state through the orchestration of osteoclasts and osteoblasts. Osteoblasts are derived mainly from mesenchymal stem cell (MSC) and are responsible for bone formation. The inhibition of osteoblast prolife...
Single-cell transcriptome deciphers key targets of thrombopoietin receptor agonists and immune microenvironment characteristics of immune thrombocytopenia [0.03%]
单细胞转录组揭示免疫性血小板减少的关键治疗靶标及免疫微环境特征
Wanru Wang,Haoxu Wang,Xiaohan Wan et al.
Wanru Wang et al.
Thrombopoietin receptor agonists (TPO-RAs) represent a cornerstone in immune thrombocytopenia (ITP) management, yet their molecular mechanisms remain incompletely elucidated. This study systematically deciphered the key targets and signalin...
Abnormal expansion of peripheral helper T cells in primary immune thrombocytopenia [0.03%]
原发性免疫性血小板减少症外周辅助T细胞的异常增殖
Qian Liu,Tianshu Yu,Yimin Zhou et al.
Qian Liu et al.
Peripheral helper T (Tph) cells, a distinct T-cell subset defined as CD4+PD-1hiCXCR5- phenotypically, are increasingly recognized as key drivers of antibody-mediated autoimmunity; however, their role in primary immune thrombocytopenia (ITP)...
GPVI deficiency reduces clot size and murine thrombosis in normoglycaemic but not hyperglycemic conditions [0.03%]
GPVI缺乏减少凝块大小和正常血糖但不是高血糖条件下的小鼠血栓形成
Julia S Gauer,Cédric Duval,Helen R McPherson et al.
Julia S Gauer et al.
Background: Glycoprotein (GP)VI is involved in platelet activation, procoagulant phenotype development and reactive oxygen species (ROS) production. Patients with diabetes have altered platelet reactivity and abnormal clo...