Thiazole orange: a complement to established methods for diagnosing inherited dense granule defects [0.03%]
噻唑橙：诊断遗传性致密颗粒缺陷 Established 方法的补充
Myriam Martin,Karin Strandberg,Eva Zetterberg et al.
Myriam Martin et al.
Inherited delta storage pool deficiencies are likely underdiagnosed due to limitations in available diagnostic tools. Achieving accurate diagnosis is thus challenging for clinical laboratories highlighting the need for improved methods. Our...
Evaluation of platelet dense granules by transmission electron microscopy in healthy pediatric donors and pediatric patients with suspected platelet disorders [0.03%]
健康儿科供者和疑似血小板疾病患儿的血小板致密颗粒的透射电子显微镜评估
Jacob R Greenmyer,Dong Chen,Kyle G Howell et al.
Jacob R Greenmyer et al.
Background: Whole mount (WM) platelet transmission electron microscopy (PTEM) is a standard method for evaluating platelet dense granules (DG). However, because of the lack of a pediatric/adolescent mean DG/platelet refer...
Improved micro-sampling methodology enables accurate platelet function analysis [0.03%]
改进的微采样方法学实现对血小板功能的精确分析
Tyler L Horn,Abhishek Sadhu,Hind O Alosaimi et al.
Tyler L Horn et al.
Micro-sampling for platelet function assays offers a minimally invasive alternative to venipuncture that may facilitate point-of-care testing. We have developed a new micro-sampling methodology for human and mouse and evaluated these method...
The effect of human platelet lysate on self-renewal and homing potential of peripheral blood -derived hematopoietic stem cells [0.03%]
人血小板溶酶对外周血造血干细胞自我更新和归巢潜能的影响
Zahra Najafi,Farnaz Pirsavabi,Saeed Mohammadi et al.
Zahra Najafi et al.
Hematopoietic stem and progenitor cells (HSPCs) hold significant promise for various diseases and gene therapy, highlighting the need for improved in vitro expansion while maintaining their properties. Efficient HSPC expansion requires an e...
Use of a conditional Glanzmann thrombasthenia mouse model reveals a supportive and possibly non-adhesive role for TLT-1 in the platelet-fibrinogen interaction [0.03%]
条件性Glanzmann血小板病小鼠模型的建立揭示了TLT-1在血小板与纤维蛋白原相互作用中可能发挥支持和非粘附作用
Siobhan Branfield,Nicholas Koshy,Yashieta Somani et al.
Siobhan Branfield et al.
The platelet integrin receptor, αIIbβ3, binds fibrinogen to mediate platelet-platelet contacts, regulate hemostasis, and modulate inflammation. The Triggering Receptor Expressed in Myeloid (TREM) - Like (TLT)-1 is an enigmatic 34kD recept...
Computational modeling of platelet activation signatures in response to diverse immune and hemostatic agonists [0.03%]
血小板激活标志物对多种免疫和止血激动剂的计算建模
Fabrice Cognasse,Kim Anh Nguyen,Marco Heestermans et al.
Fabrice Cognasse et al.
Platelets are increasingly recognized as key players not only in hemostasis, but also in immunity and inflammation. However, the mechanisms and markers underlying their activation remain incompletely understood. This study aimed to decipher...
Challenges in diagnosing sticky platelet syndrome using light transmission aggregometry: a scoping review [0.03%]
光学透射聚集法在诊断粘板症中的挑战：系统综述
Yupeng Wu,Floris van Dellen,Hugo Ten Cate et al.
Yupeng Wu et al.
Sticky Platelet Syndrome (SPS) is an inherited platelet hyperreactivity disorder associated with recurrent arterial and venous thrombosis. However, its diagnosis remains controversial due to substantial variability in light transmission agg...
Comparison of in-hospital net clinical outcomes of ticagrelor and clopidogrel in acute coronary syndrome patients stratified by CRUSADE score: findings from the CCC-ACS registry [0.03%]
基于CRUSADE评分急性冠脉综合征患者在接受替格瑞洛与氯吡格雷治疗的住院净临床预后对比：中国当代急性冠状动脉综合征注册登记研究结果
Zuoyi Zhou,Haotai Xie,Fangfang Fan et al.
Zuoyi Zhou et al.
Objectives: To compare the effect of ticagrelor and clopidogrel on net clinical outcomes in patients with acute coronary syndrome (ACS) and assess the CRUSADE score's utility in guiding the selection of P2Y12 inhibitors. ...
Observational Study
Platelets. 2025 Dec;36(1):2570743. DOI:10.1080/09537104.2025.2570743 2025
The effect of testosterone on platelet activation and inflammation in transgender men [0.03%]
睾酮对变性男性血小板活化和炎症的影响
Lieve Mees van Zijverden,Moya Henriëtte Schutte,Marieke Tebbens et al.
Lieve Mees van Zijverden et al.
Background and aims: Transgender men (female sex assigned at birth, male gender identity) who use testosterone have a higher cardiovascular risk compared to women and men from the general population, which cannot be fully...
Dornhorst's model revisited: an error identified in the equation for platelet survival [0.03%]
重新审视Dornhorst模型：血小板生存方程中的一个错误被识别出来
Woo Young Shin,Kyeong Deok Kim,Keon-Young Lee
Woo Young Shin