The Orexin System Modulates Stress-Induced Alcohol Preference and Reinstatement in Adolescents: Bioinformatics and Experimental Evidence [0.03%]
生物信息学和实验证据表明 orexin 系统可调节应激诱导的青少年酒精偏好和复吸行为
Wenhao He,Aqian Hu,Tianshu Zhao et al.
Wenhao He et al.
Underage drinking has become a global public health concern. One of the major causes of underage drinking is stress. The orexin system has been reported to be involved in both alcohol addiction and stress. However, few studies have examined...
Andreas Heinz,Selin Icoez,Yvonne Treusch et al.
Andreas Heinz et al.
Pavlovian and operant learning mechanisms promote and maintain alcohol intake despite aversive consequences. Here, we review the evidence for drug-associated modifications of basic learning mechanisms during the initiation and maintenance o...
Predicting Outpatient Follow-Up Retention After Inpatient Treatment in Patients With Alcohol Use Disorder: A Data-Driven Random Forest Approach [0.03%]
基于数据驱动的随机森林方法预测酒精使用障碍患者的住院治疗后门诊随访依从性
Jennifer J Barb,Lillian C King,Alexandria N Hughes et al.
Jennifer J Barb et al.
Longer treatment engagement is associated with improved recovery outcomes in alcohol use disorder (AUD), making patient retention a critical determinant of reduced return to drinking. This study aimed to identify factors predicting outpatie...
Investigating Bidirectional Causal Relationships Between Imaging-Derived Brain Phenotypes and Sedative-Hypnotic Use Disorder: A Mendelian Randomization Study [0.03%]
基于影像的脑表型与镇静催眠药物使用障碍之间的双向因果关系研究：孟德尔随机化研究
Liqin Lu,Guoxin Zhuang,Jue Deng et al.
Liqin Lu et al.
Despite sedative-hypnotic use disorder (SHUD) being a major public health priority due to its high abuse liability, the underlying causal neurobiological mechanisms of individual susceptibility remain largely unknown. We conducted a large-s...
Cortical and Subcortical Signatures of Incentive Salience Attribution in Tobacco Use Disorder [0.03%]
烟草使用障碍中 incentive salience 归因的皮层和皮层下结构特征研究
Nicola Sambuco,Francesco Versace,Brian A Taylor
Nicola Sambuco
Relapse is a defining feature of substance use disorders, yet relapse risk varies widely across individuals. This variability has been linked to individual differences in incentive salience attribution to drug-related cues. We used fMRI to ...
Long-Acting Naltrexone Restores Network Connectivity in Subjects With Comorbid Cannabis and Opioid Use Disorder [0.03%]
长效纳曲酮可恢复大麻和阿片类物质使用障碍共病患者的网络连接性
Lindsey M Brier,Daniel D Langleben,Corinde E Wiers et al.
Lindsey M Brier et al.
Comorbid substance use disorders (SUDs) are common but difficult to study due to the complex, interacting and overlapping mechanisms through which they affect brain networks. Many datasets collected to investigate a specific SUD include par...
rTMS Suppresses Tobacco Craving via Enhanced Prefronto-Striato-Thalamic Connectivity [0.03%]
重复经颅磁刺激通过增强皮层下环路连接抑制烟草渴求
Xin Luo,Xuefeng Ma,Shuang Li et al.
Xin Luo et al.
Studies have used repetitive transcranial magnetic stimulation (rTMS) to stimulate the left dorsolateral prefrontal cortex (DLPFC) in patients with tobacco use disorder (TUD); consequently, decreased craving for smoking was observed. Howeve...
A Membrane-Centric Plasma Lipidomic Signature of Response to Long-Acting Naltrexone in Alcohol Use Disorder [0.03%]
长效纳曲酮治疗酒精使用障碍的膜中心型血浆脂质组学标志物研究
Liyao Huang,Bojie Zhou,Qinling Ou et al.
Liyao Huang et al.
Long-acting naltrexone is a first-line pharmacotherapy for alcohol use disorder (AUD), but clinical response is heterogeneous and the underlying biology remains incompletely understood. In a randomised, double-blind, placebo-controlled tria...
Randomized Controlled Trial
Addiction biology. 2026 May;31(5):e70165. DOI:10.1111/adb.70165 2026
Investigating Factors Associated With Spontaneous Remission in Individuals With Alcohol Use Disorder-Results From a Multi-Site Longitudinal Cohort Study [0.03%]
关于酒精使用障碍自然康复的影响因素的研究——多中心纵向队列研究的结果分析
Judith Zaiser,Johannes Nitsche,Sabine Hoffmann et al.
Judith Zaiser et al.
Alcohol use disorder (AUD) is considered a chronic disorder with a highly variable course. Understanding this variability is crucial for identifying factors associated with persistence versus spontaneous remission. We analysed data from N =...
Observational Study
Addiction biology. 2026 May;31(5):e70153. DOI:10.1111/adb.70153 2026