Sleep Slow-Wave and Spindle Alterations in Young Smokers Correlated With the Severity of Cigarette Exposure [0.03%]
Shuailin Ding,Ting Xue,Fang Dong et al.
Shuailin Ding et al.
Smoking is closely associated with significant disruptions in sleep architecture. Although previous studies have reported altered self-reported sleep quality in adolescent smokers, relatively few studies using polysomnography have objective...
The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats [0.03%]
胆碱酯酶抑制剂多奈哌齐增加伏核多巴胺水平并阻断酒精剥夺效应
Anna Loftén,Klara Danielsson,Louise Adermark et al.
Anna Loftén et al.
Alcohol use disorder is associated with substantial morbidity and mortality arising from both medical consequences and accidents. Currently available pharmacotherapies are limited, and novel treatment options are needed. One putative target...
The Interaction Between Mental Distress and Opioid Maintenance Treatment Impacts Levels of Circulating Cytokines [0.03%]
心理压力与阿片类药物维持治疗的相互作用会影响循环细胞因子水平
Kristin Nygård-Odeh,Hedda Soløy-Nilsen,Magnhild Gangsøy-Kristiansen et al.
Kristin Nygård-Odeh et al.
Opioid use modulates parts of the immune system, including cytokines, but with disparate results. Furthermore, several studies have demonstrated a positive correlation between circulating proinflammatory cytokines and mental distress of var...
Sex Difference in Brain Responses During Short Abstinence in People With Internet Gaming Disorder [0.03%]
互联网游戏障碍者短期戒除期间大脑反应的性别差异
Shaoyu Cui,Xuefeng Xu,Guangheng Dong
Shaoyu Cui
Withdrawal or the adverse response to abstinence is a significant marker of addiction; however, the neural features of internet gaming disorder (IGD), especially the effects of sex under abstinence, have rarely been examined. This study aim...
Expression and Clinical Significance of the Long Non-Coding RNA OIP5-AS1 in Alcohol Use Disorder [0.03%]
长非编码RNA OIP5-AS1在酒精使用障碍中的表达及临床意义
Meng Ya Zhu,Jian Wang,Jia Jia Song et al.
Meng Ya Zhu et al.
The present study aimed to investigate the expression of OIP5-AS1 in alcohol use disorder and to explore its potential clinical relevance. A total of 78 patients with alcohol use disorder and 36 healthy controls were enrolled in this study....
Paula L Hoffman,Giordano de Guglielmo,Valentina Vengeliene et al.
Paula L Hoffman et al.
According to the 2023 National Survey on Drug Use and Health (NSDUH), 28.9 million people ages 12 and older in the United States had alcohol use disorder (AUD) in the past year. Although chronic alcohol use contributes to numerous health di...
The Buprenorphine Paradox: How Buprenorphine Triggers and Resolves Opioid Withdrawal [0.03%]
布普品非诺的悖论：布普品非诺如何引发和缓解阿片类药物戒断症状
Mehdi Haghdoost,Jennifer LaBranche,Matthew Roberts et al.
Mehdi Haghdoost et al.
Buprenorphine (BUP) offers a therapeutic approach for opioid use disorder (OUD) due to its unique pharmacodynamic properties, primarily as a partial agonist with high affinity for the mu-opioid receptor (MOR). BUP's partial agonism and ceil...
Fentanyl, Methamphetamine and Polysubstance Use Differentially Affect Locomotor Sensitisation and Social Behaviour in Rats: Psychedelic Treatment Reverses Social Deficits [0.03%]
芬太尼、甲氨蝶呤和多物质使用对大鼠运动敏感性和社会行为的差异化影响：迷幻药物治疗可逆转社会缺陷现象
Leah M Salinsky,Kyra C Diaz,Joshua L Fox et al.
Leah M Salinsky et al.
Polysubstance use of opioids and stimulants is increasingly common among individuals with a substance use disorder, yet most researchers examine these substances in isolation. This gap limits our understanding of the effects of polysubstanc...