Addiction-related interactions of pregabalin with morphine in mice and humans: reinforcing and inhibiting effects [0.03%]
在小鼠和人类中与阿片类药物相互作用的普瑞巴林：促进与抑制效应
Elena Vashchinkina,Ossi Piippo,Olga Vekovischeva et al.
Elena Vashchinkina et al.
The gabapentinoid pregabalin is a rapid-acting anxiolytic and analgesic, possibly suitable in supervised opioid detoxification. However, clinicians have been cautious in using it because of its unknown addictive risk and rising number of mo...
Randomized Controlled Trial
Addiction biology. 2018 May;23(3):945-958. DOI:10.1111/adb.12538 2018
Methamphetamine promotes habitual action and alters the density of striatal glutamate receptor and vesicular proteins in dorsal striatum [0.03%]
冰毒促进习惯性行为并改变背侧纹状体中谷氨酸受体和囊泡蛋白的密度
Teri M Furlong,Laura H Corbit,Robert A Brown et al.
Teri M Furlong et al.
Goal-directed actions are controlled by the value of the consequences they produce and so increase when what they produce is valuable and decrease when it is not. With continued invariant practice, however, goal-directed actions can become ...
Neuronal representation of individual heroin choices in the orbitofrontal cortex [0.03%]
与眶额皮质中海洛因个体选择相关的神经元表征
Karine Guillem,Viridiana Brenot,Audrey Durand et al.
Karine Guillem et al.
Drug addiction is a harmful preference for drug use over and at the expense of other non-drug-related activities. We previously identified in the rat orbitofrontal cortex (OFC) a mechanism that influences individual preferences between coca...
Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain [0.03%]
酒精性脑损伤的全脑异态血氧水平依赖信号振荡及其频率特征分析
Jui-Yang Hong,Eva M Müller-Oehring,Adolf Pfefferbaum et al.
Jui-Yang Hong et al.
Chronic alcoholism is associated with widespread regional differences from controls in brain activity and connectivity dynamics measured by blood-oxygen-level-dependent (BOLD) signals. Identification of alcoholism-related neurofunctional po...
Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood [0.03%]
青春期饮酒暴露降低成年期前额皮质与纹状体的静息态功能连接性
Margaret A Broadwater,Sung-Ho Lee,Yang Yu et al.
Margaret A Broadwater et al.
Connectivity of the prefrontal cortex (PFC) matures through adolescence, coinciding with emergence of adult executive function and top-down inhibitory control over behavior. Alcohol exposure during this critical period of brain maturation m...
Cocaine and HIV are independently associated with neural activation in response to gain and loss valuation during economic risky choice [0.03%]
可卡因和HIV独立影响经济风险决策中获益和损失评估的神经反应
Christina S Meade,Merideth Addicott,Andrea L Hobkirk et al.
Christina S Meade et al.
Stimulant abuse is disproportionately common in HIV-positive persons. Both HIV and stimulants are independently associated with deficits in reward-based decision making, but their interactive and/or additive effects are poorly understood de...
A new generation of mTORC1 inhibitor attenuates alcohol intake and reward in mice [0.03%]
一种新的mTORC1抑制剂可减轻小鼠的酒精摄入和欣快感
Nadege Morisot,Christopher J Novotny,Kevan M Shokat et al.
Nadege Morisot et al.
Alcohol use disorder (AUD) is a chronic condition associated with devastating socioeconomic consequences. Yet, pharmacotherapies to treat behavioral phenotypes such as uncontrolled heavy drinking are limited. Studies in rodents suggest that...
Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions [0.03%]
在惩罚性戒毒后的诱发复吸与皮层和次级脑区的激活有关
Yann Pelloux,Jennifer K Hoots,Carlo Cifani et al.
Yann Pelloux et al.
We recently developed a rat model of context-induced relapse to alcohol seeking after punishment-imposed abstinence to mimic relapse after self-imposed abstinence due to adverse consequences of drug use. Here, we determined the model's gene...
Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens [0.03%]
酰胺酶（FAAH）失活可增强尼古丁诱发的大鼠伏核多巴胺释放的敏感性
Francisco J Pavon,Antonia Serrano,Nimish Sidhpura et al.
Francisco J Pavon et al.
Nicotine exerts its rewarding effects by promoting an increase in dopamine (DA) release in the nucleus accumbens (NAc), and this process is influenced by the endocannabinoid system. Fatty acid amide hydrolase (FAAH) is the main enzyme respo...
Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens [0.03%]
伏隔核D1DR中棘神经元长期特异性编码增强的饮酒行为
Rafael Renteria,Tavanna R Buske,Richard A Morrisett
Rafael Renteria
The nucleus accumbens (NAc) is a critical component of the mesocorticolimbic system and is involved in mediating the motivational and reinforcing aspects of ethanol consumption. Chronic intermittent ethanol (CIE) exposure is a reliable mode...