AAV-Mediated Expression of Methamphetamine Monoclonal Antibody Attenuates Methamphetamine Behaviour Sensitization in Mice [0.03%]
利用腺相关病毒表达抗甲基苯丙胺单克隆抗体减轻小鼠的甲基苯丙胺行为敏化现象
Yun-Hsiang Chen,Tsai-Wei Hung,Yu-Syuan Wang et al.
Yun-Hsiang Chen et al.
Methamphetamine (Meth) is a psychoactive and neurotoxic chemical. Selective antibodies against Meth molecules have been examined for the treatment of Meth abuse through immunization. Antibodies with high affinity for Meth can capture Meth m...
Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings [0.03%]
大麻使用者接触诱因与增加的中脑边缘多巴胺系统内固有连接性之间的关联：初步发现
Natalia M Kleinhans,Garth E Terry,Dahyeon Kang et al.
Natalia M Kleinhans et al.
Cue-induced craving-the desire to use a drug triggered by exposure to cues associated with prior use-is a central mechanism in the development and maintenance of problematic substance use behaviours. Drug cues have the power to induce cravi...
Sarah Witley,Sebastian Blid Sköldheden,Christian E Edvardsson et al.
Sarah Witley et al.
While alcohol use disorder can be treated with pharmacological interventions, ketosis is a recently proposed treatment option. Ketosis, defined by elevated concentrations of ketone bodies such as β-hydroxybutyrate (BHB), can be induced by ...
Machine Learning Classification of Smoking Behaviours-From Social Environment to the Prefrontal Cortex [0.03%]
从社会环境到前额叶皮质的吸烟行为机器学习分类
Pablo Reinhardt,Norman Zacharias,Marinus Fislage et al.
Pablo Reinhardt et al.
The pronounced heterogeneity in smoking trajectories-ranging from occasional or heavy use to successful quitting -highlights substantial interindividual variation within the smoking population. Machine learning is particularly well suited t...
BDNF Haplotype and Personality Traits May Influence the Development of Alcohol Use Disorder in the Han Chinese Population [0.03%]
BDNF基因单体型及人格特质与中国汉人酒精使用障碍的发病关联研究
Yi-Hsin Wang,Yi-Wei Yeh,Chun-Long Lin et al.
Yi-Hsin Wang et al.
Brain-derived neurotrophic factor (BDNF) and personality traits play a crucial role in the development of alcohol use disorder (AUD). However, the relationship between the BDNF gene, personality and AUD remains unclear. This study aimed to ...
Arginine Metabolism and Adenosine Receptor Signals in the Cerebellum Contribute to Nicotine Withdrawal-Induced Anxiety/Depression-Like Behaviours [0.03%]
尼古丁戒断引起的焦虑/抑郁样行为与小脑中的鸟氨酸代谢和腺苷受体信号有关
Wenjuan Zhang,Yu Tian,Xiao Yang et al.
Wenjuan Zhang et al.
Recent studies have established a strong association between the cerebellum and various psychiatric disorders, as well as drug addiction and withdrawal processes. However, the mechanisms underlying the cerebellum's role in nicotine withdraw...
Lei Liu,Bo Zhang,Yong Dong et al.
Lei Liu et al.
Alcohol use disorder is closely related to genetic and environmental factors. However, the contribution of coding variation to alcohol use disorder susceptibility remains poorly understood. We aimed to identify genetic mutations in alcohol ...
Grey Matter Volume in Substance Use: A Preregistered, Dimensional Approach to Disentangle Substance Use and Disorder Severity [0.03%]
物质使用中的灰质体积：一种预先注册的、维度化的方法来区分物质使用的严重程度
Kristina Schwarz,Malin K Hildebrandt,Nele Sauer et al.
Kristina Schwarz et al.
This preregistered study investigates whether altered grey matter volume (GMV) in the insula and ventromedial prefrontal/anterior cingulate cortex (vmPFC/ACC) - regions commonly implicated in substance use disorder (SUD) - is associated wit...
AMPA Receptor Within the Prelimbic Cortex Regulates Propofol-Induced Locomotor Sensitization [0.03%]
丙泊酚诱导的运动敏感性与前扣带皮层中的AMPA受体有关
Chi Pan,Xinyu Mao,Yujie Jiang et al.
Chi Pan et al.
Propofol is recognized as an addictive substance in both humans and animals. Increasing evidence suggests that the prelimbic cortex (PL) within the medial prefrontal cortex (mPFC), plays an important role in mediating drug addiction. In thi...
Impaired Interference Control in Individuals With Internet Addiction: Evidence From Event-Related Potentials and Brain Oscillations [0.03%]
网络成瘾者注意控制功能受损：来自事件相关电位和脑振荡的证据
Farzad Rostami,Ali Esteki,Sepideh Khoniveh et al.
Farzad Rostami et al.
Individuals with Internet addiction disorder (IAD) exhibit deficits in cognitive control, particularly in interference control; however, the behavioural and neural mechanisms underlying these impairments remain unclear. In this study, class...