Brain Transcriptome Analysis Reveals Exercise Improves Methamphetamine-Induced Impairments in Mouse Learning and Memory Abilities [0.03%]
脑转录组分析表明运动改善甲基苯丙胺致小鼠学习记忆能力损伤
Qiuyue Huang,Jisheng Xu,Xuejie Zhang et al.
Qiuyue Huang et al.
Methamphetamine (METH) abuse can inflict profound and enduring neurotoxic effects on the brain, culminating in cognitive dysfunction and impairment of learning and memory. Physical exercise can stimulate both structural and functional adapt...
No Relevant Associations Between Markers of Smoking Behaviour and Plasma Progesterone Concentrations: Findings From a Sex-Stratified Cohort Study [0.03%]
基于性别分层队列研究的吸烟行为标志物与血浆孕酮浓度无相关性
Julia Gihl,Norman Zacharias,Sabine Hoffmann et al.
Julia Gihl et al.
Cigarette smoking is a prevalent and critical global health issue, with inconsistent findings for its effects on endogenous progesterone concentrations. This large multicentre study investigated the associations between various markers of s...
Multicenter Study
Addiction biology. 2025 Aug;30(8):e70071. DOI:10.1111/adb.70071 2025
AAV-Mediated Expression of Methamphetamine Monoclonal Antibody Attenuates Methamphetamine Behaviour Sensitization in Mice [0.03%]
利用腺相关病毒表达抗甲基苯丙胺单克隆抗体减轻小鼠的甲基苯丙胺行为敏化现象
Yun-Hsiang Chen,Tsai-Wei Hung,Yu-Syuan Wang et al.
Yun-Hsiang Chen et al.
Methamphetamine (Meth) is a psychoactive and neurotoxic chemical. Selective antibodies against Meth molecules have been examined for the treatment of Meth abuse through immunization. Antibodies with high affinity for Meth can capture Meth m...
Increased Mesostriatal Intrinsic Connectivity Associated With Cue Exposure in Adult Cannabis Users: Preliminary Findings [0.03%]
大麻使用者接触诱因与增加的中脑边缘多巴胺系统内固有连接性之间的关联：初步发现
Natalia M Kleinhans,Garth E Terry,Dahyeon Kang et al.
Natalia M Kleinhans et al.
Cue-induced craving-the desire to use a drug triggered by exposure to cues associated with prior use-is a central mechanism in the development and maintenance of problematic substance use behaviours. Drug cues have the power to induce cravi...
Sarah Witley,Sebastian Blid Sköldheden,Christian E Edvardsson et al.
Sarah Witley et al.
While alcohol use disorder can be treated with pharmacological interventions, ketosis is a recently proposed treatment option. Ketosis, defined by elevated concentrations of ketone bodies such as β-hydroxybutyrate (BHB), can be induced by ...
Machine Learning Classification of Smoking Behaviours-From Social Environment to the Prefrontal Cortex [0.03%]
从社会环境到前额叶皮质的吸烟行为机器学习分类
Pablo Reinhardt,Norman Zacharias,Marinus Fislage et al.
Pablo Reinhardt et al.
The pronounced heterogeneity in smoking trajectories-ranging from occasional or heavy use to successful quitting -highlights substantial interindividual variation within the smoking population. Machine learning is particularly well suited t...
BDNF Haplotype and Personality Traits May Influence the Development of Alcohol Use Disorder in the Han Chinese Population [0.03%]
BDNF基因单体型及人格特质与中国汉人酒精使用障碍的发病关联研究
Yi-Hsin Wang,Yi-Wei Yeh,Chun-Long Lin et al.
Yi-Hsin Wang et al.
Brain-derived neurotrophic factor (BDNF) and personality traits play a crucial role in the development of alcohol use disorder (AUD). However, the relationship between the BDNF gene, personality and AUD remains unclear. This study aimed to ...
Arginine Metabolism and Adenosine Receptor Signals in the Cerebellum Contribute to Nicotine Withdrawal-Induced Anxiety/Depression-Like Behaviours [0.03%]
尼古丁戒断引起的焦虑/抑郁样行为与小脑中的鸟氨酸代谢和腺苷受体信号有关
Wenjuan Zhang,Yu Tian,Xiao Yang et al.
Wenjuan Zhang et al.
Recent studies have established a strong association between the cerebellum and various psychiatric disorders, as well as drug addiction and withdrawal processes. However, the mechanisms underlying the cerebellum's role in nicotine withdraw...
Lei Liu,Bo Zhang,Yong Dong et al.
Lei Liu et al.
Alcohol use disorder is closely related to genetic and environmental factors. However, the contribution of coding variation to alcohol use disorder susceptibility remains poorly understood. We aimed to identify genetic mutations in alcohol ...
Grey Matter Volume in Substance Use: A Preregistered, Dimensional Approach to Disentangle Substance Use and Disorder Severity [0.03%]
物质使用中的灰质体积：一种预先注册的、维度化的方法来区分物质使用的严重程度
Kristina Schwarz,Malin K Hildebrandt,Nele Sauer et al.
Kristina Schwarz et al.
This preregistered study investigates whether altered grey matter volume (GMV) in the insula and ventromedial prefrontal/anterior cingulate cortex (vmPFC/ACC) - regions commonly implicated in substance use disorder (SUD) - is associated wit...