Laís da Silva Pereira-Rufino,Raissa Mazzer de Sino Romano,Regiane Chiavelli Lamim et al.
Laís da Silva Pereira-Rufino et al.
Alcohol use disorder (AUD) is a chronic and progressive disease that affects individuals worldwide. AUD individuals exhibit epigenetic alterations across tissues, mainly in the brain. Despite advances in the field, there is a gap in epigeno...
DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization [0.03%]
DNA甲基化通过调节CDK5R1和NRBP1基因来影响酒精依赖性：来自孟德尔随机化的启示
Fuyuan Deng,Junsheng Peng,Siran Lai et al.
Fuyuan Deng et al.
Alcohol dependence currently lacks targeted pharmacotherapies, underscoring the urgent need for novel therapeutic targets. Existing research on disease-associated DNA methylation changes and their gene regulatory effects remains inconsisten...
Cognitive Behavioural Therapy Group Counselling for Nicotine Dependence in College Students: Behavioural and Resting-State EEG Microstate Evidence [0.03%]
针对大学生尼古丁依赖的认知行为疗法团体咨询：行为及静息态EEG微状态证据
Jiayue Zou,Can Zhang,Xiaoyu Dai et al.
Jiayue Zou et al.
Nicotine dependence is a chronic and relapsing disorder, with elevated onset risk during college years. Hence, we focus on college students and examine the immediate and short-term effects of 6-week cognitive behavioural therapy (CBT) group...
Randomized Controlled Trial
Addiction biology. 2026 Apr;31(4):e70158. DOI:10.1111/adb.70158 2026
In Vivo Imaging of Neuronal Activity Shifts in the Somatosensory Cortex After Morphine Tolerance in Mice [0.03%]
阿片类药物耐受小鼠的躯体感觉皮层内神经元活动变化的活体成像研究
Guangyan Zhang,Weiwei Meng,Ling-Jun Xu et al.
Guangyan Zhang et al.
Morphine is widely used to treat severe pain, but its analgesic effect diminishes with repeated use due to the development of tolerance. Reversing this tolerance remains a clinical challenge, as its underlying mechanisms are complex and not...
AT1R in Central Nervous System Disorders: Unveiling Novel Mechanisms and Therapeutic Avenues for Addiction [0.03%]
中枢神经系统疾病中的AT1R：揭示成瘾的新型机制和治疗途径
Jianan Lv,Dan Zhu,Sisi Song et al.
Jianan Lv et al.
Although the angiotensin II type 1 receptor (AT1R), a pivotal component of the renin-angiotensin system (RAS), is associated with cardiovascular and renal homeostasis, burgeoning evidence implicates its critical role in neuropsychiatric dis...
Cortical Structure Alterations in Young People With Mild Internet Gaming Disorder [0.03%]
轻度网络游戏障碍患者的皮层结构变化
Bohui Mei,Longyao Ma,Qiuying Tao et al.
Bohui Mei et al.
This study aims to explore alterations in cortical structure in young individuals with early Internet gaming disorder (IGD) and to provide novel insights for early detection and intervention of disease treatment. We investigated the brain s...
Sleep Slow-Wave and Spindle Alterations in Young Smokers Correlated With the Severity of Cigarette Exposure [0.03%]
年轻人睡眠慢波和纺锤波的变化与吸烟严重程度相关性研究
Shuailin Ding,Ting Xue,Fang Dong et al.
Shuailin Ding et al.
Smoking is closely associated with significant disruptions in sleep architecture. Although previous studies have reported altered self-reported sleep quality in adolescent smokers, relatively few studies using polysomnography have objective...
The Acetylcholine Esterase Inhibitor Donepezil Increases Dopamine Levels in the Nucleus Accumbens and Blocks the Alcohol Deprivation Effect in Rats [0.03%]
胆碱酯酶抑制剂多奈哌齐增加伏核多巴胺水平并阻断酒精剥夺效应
Anna Loftén,Klara Danielsson,Louise Adermark et al.
Anna Loftén et al.
Alcohol use disorder is associated with substantial morbidity and mortality arising from both medical consequences and accidents. Currently available pharmacotherapies are limited, and novel treatment options are needed. One putative target...
The Interaction Between Mental Distress and Opioid Maintenance Treatment Impacts Levels of Circulating Cytokines [0.03%]
心理压力与阿片类药物维持治疗的相互作用会影响循环细胞因子水平
Kristin Nygård-Odeh,Hedda Soløy-Nilsen,Magnhild Gangsøy-Kristiansen et al.
Kristin Nygård-Odeh et al.
Opioid use modulates parts of the immune system, including cytokines, but with disparate results. Furthermore, several studies have demonstrated a positive correlation between circulating proinflammatory cytokines and mental distress of var...