Synthetic approaches to endothelin receptor antagonists in clinical development [0.03%]
临床研究中的内皮素受体拮抗剂的合成方法学
W M Clark
W M Clark
The increasing structural and stereochemical complexity of new drug candidates continues to pose numerous synthetic challenges for pharmaceutical process development. Often the implementation of new methodologies, and/or the novel utilizati...
Synthesis of PNU-95666E [0.03%]
PNU-95666E的合成
P G Wuts
P G Wuts
PNU-95666E is being developed for the treatment of Parkinson's disease. This review will describe the syntheses of this D2 agonist proceeding from the very early routes to a usable production route.
The synthesis of CP-195543, an LTB4 antagonist for the treatment of inflammatory diseases [0.03%]
LTB4拮抗剂CP-195543的合成及其在炎症疾病治疗中的应用研究
S Caron
S Caron
A review of the process research and development of CP-195543 is presented. This chronological depiction from the original medicinal chemistry synthesis, which yielded a few grams of final product, to a novel route which allowed the compoun...
C M Cimarusti,P N Confalone
C M Cimarusti
H J Lee,Z You,D H Ko et al.
H J Lee et al.
S Hicks,H Assefa,R Sindelar
S Hicks
R P McGeary,D P Fairlie
R P McGeary
A J Murphy,J I Paul,D R Webb
A J Murphy