D A Smith,B Jones
D A Smith
Variability in drug response can reside within the pharmacokinetic (PK) or the pharmacodynamic phase (PD) of the classical PK/PD model. Some reasons for variability in the pharmacokinetic phase are additive and therefore should be targets f...
A Leone-Bay,D R Paton
A Leone-Bay
Macromolecules comprise a growing group of new therapeutics with great clinical promise. To date, these drugs are limited in their application because they are effective only when administered parenterally. Unfortunately, however, macromole...
M K Bayliss,L W Frick
M K Bayliss
The profound technological advances that are now occurring early in the drug discovery process have enabled lead identification groups to deliver very large numbers of promising compounds to the project teams responsible for lead optimizati...
C L Crespi
C L Crespi
Recent progress has been made in increasing the throughput of measurements of cytochrome P450-mediated metabolism of drug candidates. This review focuses on two innovations: (i) the reduction of the number of samples for HPLC-based analyses...
The chemistry of metabolic and toxicological processes. Editorial overview [0.03%]
代谢和毒理过程的化学反应综述编辑观点文章
D E Johnson,D A Smith
D E Johnson
R D Larsen
R D Larsen
Palladium-catalyzed reactions are having a great impact on the synthesis of medicinal agents due to their ability to form carbon-carbon and carbon-heteroatom bonds effectively. Quite often the palladium-catalyzed step(s) in a synthesis is k...
J M Nuss,P A Renhowe
J M Nuss
Combinatorial chemistry is now regarded as an important component of the drug discovery process and is increasingly having an impact in other areas of the chemical sciences, such as catalysis and materials science. Solid-supported organic s...
Selected, recent developments in the chemical synthesis of biologically-active natural products [0.03%]
近来生物活性天然产物化学合成的若干进展
E J Sorensen
E J Sorensen
Natural products are the basis of time-honored folk medicines and many of our most successful pharmaceuticals, and have stimulated profound advances in organic chemistry. The breath-taking multiformity of natural products fuels the drug dis...
C H Senanayake,D Krishnamurthy
C H Senanayake
During the past few years, asymmetric synthetic methods have become an indispensable tool in the process research arena for the production of enantiopure materials. The development of a truly efficient, reliable and economically viable asym...
Z Zhang,J Y Tang
Z Zhang
Progress in the field of oligonucleotide therapeutics has required commercial-scale production of oligonucleotides from multigram to multikilogram. The demand for large quantities of oligonucleotides has been met to date by the scaling-up o...