U Rudolph,H Mohler
U Rudolph
In the process of drug discovery, different classes of genetically-modified animals are valuable tools for the identification of drug targets, distinction of target isoforms, differentiation of signaling pathways, generation of disease mode...
S M Sullivan
S M Sullivan
Non-viral gene therapy refers to plasmid-based gene delivery systems for the delivery of genes encoding therapeutic proteins to diseased tissue. The genes are encoded on DNA plasmids that are propagated in bacteria. The purified plasmids ca...
Genetic immunization: applying recombinant DNA technology in the immune system to develop new vaccines [0.03%]
基因免疫学：将重组DNA技术应用于免疫系统以开发新型疫苗
M A Barry
M A Barry
Genetic immunization is a new method for vaccine development where the gene for an antigen is introduced into the host, such that the host cells produce vaccine antigens in vivo. By producing antigens intracellularly, genetic immunization i...
Recombinant antibodies for the diagnosis and therapy of human diseases [0.03%]
人源化重组抗体诊断和治疗人类疾病的研究进展及应用前景
D J King,J R Adair
D J King
It is nearly 25 years since the first description of monoclonal antibodies. During that time, monoclonal antibodies and derivatives have become a major group of pharmaceuticals in development. Technical problems have, however, hindered thei...
Recent progress towards the identification of selective inhibitors of serine/threonine protein kinases [0.03%]
寻找选择性Ser/Thr蛋白激酶抑制剂的研究进展
J L Adams,D Lee
J L Adams
Protein serine/threonine kinases figure prominently among the molecular targets currently being pursued by the pharmaceutical industry. Given the conserved tertiary structure and catalytic mechanism of the mammalian kinase superfamily, it i...
F D King,S Wilson
F D King
Approximately half of the currently known drugs act on cell surface receptors, the majority of which are 7-transmembrane (7-TM) receptors. The advent of genomic technologies has provided drug discovery scientists with a plethora of fascinat...
D Ecker,D Horwell
D Ecker
Emerging technologies for accelerated toxicity evaluation of potential drug candidates [0.03%]
药物候选化合物毒性评估的新兴技术
M D Todd,R G Ulrich
M D Todd
The current trend in the pharmaceutical industry is to shorten the timelines for all aspects of drug discovery. Although several well-established methods are used for routine toxicological evaluation, new, innovative tools are being designe...
D E Johnson,R A Braeckman,G H Wolfgang
D E Johnson
Designing and validating innovative high-throughput screening programs for toxicology requires an in-depth knowledge base on toxicokinetics and toxicodynamics (TK/TD), the two key elements of dose-response. This information is usually obtai...
Drug selection in early drug development: screening for acceptable pharmacokinetic properties using combined in vitro and computational approaches [0.03%]
基于体外和计算相结合的方法筛选具有可接受药代动力学性质的候选药物
P J Sinko
P J Sinko
In the United States, only one in ten new chemical entities (NCEs) will successfully progress to the clinic. More than two-thirds of those that fail in development, other than for unacceptable efficacy, are the result of poor absorption, di...