Computer-aided molecular selection and design of natural bioactive molecules [0.03%]
计算辅助天然生物活性分子的选择和设计
P Bernard,J Y Berthon,J R Chrétien
P Bernard
The search for natural bioactive compounds has led to a renewal of interest in exploring the plant kingdom. Indeed, a more rational search for innovative natural active compounds has become a priority. This review describes the search for n...
G Grethe
G Grethe
Structure-based reaction information management systems have been available to synthetic chemists for 30 years. The initial synthesis planning systems were supplemented 10 years later by reaction retrieval programs. After a short summary of...
O F Güner,O Casher
O F Güner
With the explosive growth in the use of the World Wide Web, which provides a 'user-friendly' interface to the Internet, accessing information through Web browsers has become a common task for scientists seeking proprietary or public informa...
A Polinsky
A Polinsky
New developments in cheminformatics are reviewed in the perspective of combinatorial chemistry and drug discovery. One of the most important trends is the realization that the ability to generate compounds in large numbers may not, in isola...
R Hull,A Jenkins,M Zweerink
R Hull
"Mendel's concept of the laws of genetics was lost to the world for a generation because his publication did not reach the few who were capable of grasping and extending it; and this sort of catastrophe is undoubtedly being repeated all abo...
F Brown,P Gund
F Brown
P E Daddona
P E Daddona
Controlled delivery of macromolecular drugs, such as peptides, proteins, oligonucleotides and polysaccharides remains a major challenge. While these drugs can be administered by subcutaneous injection or intravenous infusion, more convenien...
R T Bartus
R T Bartus
The blood-brain barrier (BBB) serves as an exquisitely controlled, functional gate to the central nervous system (CNS). It not only protects the brain from agents in the blood that could impair neurological function, but also controls the i...
J K Taylor,N M Dean
J K Taylor
Numerous human diseases arise from mutations that result in aberrant RNA splicing. To date, traditional therapeutic approaches have not been successful in targeting these mutations and restoring correct splicing. Antisense oligonucleotides ...
C Wahlestedt,L Good
C Wahlestedt
Antisense oligonucleotides provide attractive possibilities for developing a new class of drugs and the design principle involves straightforward base-pairing rules. The approach has already been useful in many functional genomics efforts a...