B N Pramanik,P L Bartner,G Chen
B N Pramanik
The structure characterization of biologically-active organic compounds, developed from synthetic and natural sources, is an integral part of the drug discovery effort to identify novel therapeutic agents. Mass spectrometric methods (electr...
M J Shapiro,J R Wareing
M J Shapiro
High resolution NMR spectroscopy has provided a versatile tool for assessing ligand/receptor interactions. NMR-based methods are currently being investigated which may prove valuable for compound screening. These techniques include the use ...
M Lebl
M Lebl
Developments in the solid-phase synthesis of combinatorial libraries during 1998 are reviewed with emphasis on the rapid synthesis of libraries, new techniques for analysis of reaction progress and synthetic results, application of solid-ph...
M J Suto
M J Suto
The use of solution-phase parallel synthesis as a means of producing libraries of compounds for lead discovery and optimization has increased steadily. More emphasis has been placed on the development of techniques that are applicable acros...
Recent developments in solid- and solution-phase methods for generating carbohydrate libraries [0.03%]
近年来在固体和溶液体系中制备糖库的进展
M J Sofia,D J Silva
M J Sofia
Carbohydrates and glycoconjugates have attracted a great deal of attention in recent years because of the key roles they play in biological processes. The development of carbohydrate-based libraries is a crucial step towards investigating t...
A B Reitz
A B Reitz
The use of solid-phase organic synthesis for the preparation of small molecule compound libraries has been the driving force behind the development of new linkers and reaction technologies. Traceless linkers afford targets in which it is no...
J W Ellingboe
J W Ellingboe
Solid-phase synthesis is a valuable tool for drug discovery research. The value is particularly evident in lead optimization work where it contributes to the rapid and thorough identification of the optimal drug candidate within a lead seri...
K Gordon,S Balasubramanian
K Gordon
This review features selected articles from the literature from January 1998 to March 1999 involving solid-phase chemical methodologies. Areas of particular interest highlighted include studies that have given new insight into the influence...
M S Lee,H Nakanishi,M Kahn
M S Lee
Combinatorial chemistry, in its ability to generate vast arrays of non-peptide and non-oligonucleotide libraries, has had a major impact on the drug discovery effort. The design and generation of a combinatorial library, coupled with the ev...
P J Edwards,M Gardner,W Klute et al.
P J Edwards et al.
This article is a subjective review of the literature from 1998 to April 1999 describing combinatorial chemistry as applied to drug discovery. The first two sections cover proteinase inhibition and small molecule lead discovery for other ta...