In vitro and in vivo intestinal and hepatic oxidative metabolism of typical cytochrome P450 3A substrates, midazolam, nifedipine, and quinidine, in minipigs: A comparison with humans, monkeys, and dogs [0.03%]
典型细胞色素P450 3A底物咪达唑仑、硝苯地平和奎尼丁的 miniature猪体外和体内肠道及肝脏氧化代谢研究：与人、猴和狗的比较
Chizuka Sakai,Eriko Higashi,Shunsuke Iwano et al.
Chizuka Sakai et al.
1. This study evaluated intestinal and hepatic first-pass metabolism of CYP3A substrates (midazolam, nifedipine, and quinidine) in minipigs and compared results with in vivo data reported for humans, monkeys, and dogs, and with in vitro dat...
Formaldehyde directly induces cytotoxicity in human lymphocytes through ROS formation, mitochondrial/lysosomal destruction and oxidative stress; analysis of the protective effects of crocin [0.03%]
花青通过ROS生成、线粒体和溶酶体损伤及氧化应激直接诱导人淋巴细胞细胞毒性的机制分析及其保护作用研究
Ahmad Salimi,Hanieh Delavari,Behrooz Elyasi et al.
Ahmad Salimi et al.
Here we investigated the direct effect of formaldehyde, a major environmental and occupational pollutant, and cytoprotective potency of crocin as a natural compound against its toxicity in human lymphocytes, an important immune cell.For thi...
An LC-MS/MS method for simultaneous quantification of six components of Angelicae pubescentis radix and systematic evaluation of Angelicae pubescentis radix as a potential inhibitor of multiple cytochrome P450 enzymes [0.03%]
一种同时量化中乌头根中六种成分的LC-MS/MS方法及系统评价中乌头根作为多种细胞色素P450酶潜在抑制剂的可能性
Jia Yao,Shunjun Yang,Ying Liu et al.
Jia Yao et al.
Quantitative analytical method was developed for six coumarin constituents in Angelicae pubescentis radix (APR), and the inhibitory effect of the herb's extract on cytochrome P450 enzymes was investigated.A liquid chromatography-tandem mass...
Comprehensive Metabolic Profiling and Enzyme Kinetics of Cis-2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside in Normal and Hyperlipidemic Rats [0.03%]
正常血脂与高血脂大鼠血浆和尿液中 cis-2,3,5,4′-四羟基 stilbene-2-o-β-d-糖苷的代谢谱及动力学研究
Jiexin Qiu,Beibei Yao,Qing Yu et al.
Jiexin Qiu et al.
Cis-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (cis-THSG), a photoisomer of the major bioactive component in Polygoni Multiflori Radix Praeparata (He-Shou-Wu), has enhanced hypolipidemic activity but is associated with idiosyncratic h...
Acute aluminum phosphide poisoning: evolving perspectives on toxic mechanisms and evidence-based clinical management [0.03%]
急性磷化铝中毒：毒理机制及循证临床治疗的新观点
Saeed Aghebat-Bekheir,Amir Baghaei,Armin Salek Maghsoudi et al.
Saeed Aghebat-Bekheir et al.
Aluminium phosphide (AlP) is a chemical compound that is used as a pesticide for suicidal purposes and can cause death, and it poses a challenge to health in some countries. AlP in the presence of stomach acid leads to the release of phosph...
A high-throughput lC-MS/mS method for simultaneous determination of lumateperone and its four metabolites in human plasma: application to a clinical trial [0.03%]
一种高通量LC-MS/MS测定人血浆中卢马特普兰及其四种代谢产物的方法：临床试验应用
Hongjie Ding,Bingda Wu,Rui Wang et al.
Hongjie Ding et al.
1. Lumateperone is an antipsychotic metabolised to four active metabolites IC200131, IC200161, IC200565 and IC201308, which are closely related to its clinical efficacy and safety.2. For evaluating the clinical pharmacokinetics of lumateper...
Evaluation of the effects of paeoniflorin on cytochrome P450 isozymes in rats [0.03%]
芍药苷对大鼠Cytochrome P450同工酶影响的评价研究
Jia-Ou Chen,Ling-Li Zhou,Jian-Heng Lin et al.
Jia-Ou Chen et al.
1. This study aims to investigate the effects of orally administered paeoniflorin (PF), a major bioactive compound from Paeonia lactiflora, on cytochrome P450 (CYP450) enzyme activity in rats to assess potential drug-drug interactions (DDIs...
Berberine Hydrochloride Induces Apoptosis in Triple-Negative Breast Cancer Cells Through Modulation of the sirtuin/p65 Signaling Axis [0.03%]
盐巴马钱子碱通过调节长寿蛋白/six家族转录抑制因子5轴诱导三阴性乳腺癌细胞凋亡
Zhimin Zhao,Shu Xu,Yushi Yang et al.
Zhimin Zhao et al.
Background: Triple-negative breast cancer (TNBC) is a highly aggressive subtype with few available therapeutic strategies. Berberine Hydrochloride (BBR) has shown anticancer potential but its mechanisms in TNBC remain unc...
Computational Analysis of Dual Targeting of β1-Adrenergic and AT1 Receptors by Bisoprolol Fumarate and Candesartan Cilexetil for Hypertensive Modulation [0.03%]
计算分析酒石酸比索洛尔和坎地沙坦酯对β1肾上腺素能受体和AT1受体双靶向作用以调节高血压
Sana Yakoubi,Abir Alatrache
Sana Yakoubi
This study explores a dual-action approach for hypertension management based on a co-formulated suspension containing Candesartan cilexetil (CC) - Bisoprolol fumarate (BF) system, combining FTIR characterization with computational modeling ...
Total saponins from ginseng stems and leaves antagonise acute lead-cadmium co-exposure-induced oxidative liver damage in mice via the Keap1/Nrf2 signalling pathway [0.03%]
人参茎叶总皂苷通过Keap1/Nrf2信号通路拮抗急性铅镉联合暴露诱发的小鼠肝脏氧化损伤
Bo Yan,Yang Wang,Yixin Xu et al.
Bo Yan et al.
1. Lead (Pb) and cadmium (Cd) induce liver damage mainly via oxidative stress. Total saponins from ginseng stems and leaves (TSGSL) possess antioxidant properties, but their protective effect against Pb-Cd co-exposure remains unclear.2. Thi...