MRM-Driven Metabolomic Workflow for Early Detection of Antibiotic-Triggered Sub-Lethal Toxicity Using Q-TRAP and Zebrafish Model [0.03%]
基于MRM的代谢组学工作流：使用Q-TRAP和斑马鱼模型早期检测抗生素引发的亚致死毒性
Patharaj Gokul,Rajesh Pamanji,Ragothaman Prathiviraj et al.
Patharaj Gokul et al.
Metabolomics offers a sensitive and comprehensive approach to detect early biochemical changes induced by environmental contaminants, providing insights beyond traditional toxicity assays. In this study, we have developed a targeted metabol...
The acute effect of glyphosate on heart mitochondria does not impair the bioenergetics [0.03%]
急性 Glyphosate 对心脏线粒体的影响不会影响生物能量学
Antonia Cugliari,Cristina Algieri,Micaela Fabbri et al.
Antonia Cugliari et al.
Considering the important role of mitochondria in mammalian cells and the close correlation between mitochondrial dysfunction and various diseases, this study evaluated the potential toxicity of glyphosate on mitochondrial function in swine...
Mechanism of Black American Ginseng saponins in ameliorating memory dysfunction in aging mice by activating the BDNF/PI3K/AKT/CREB pathway [0.03%]
黑美国人参皂苷通过激活BDNF/PI3K/AKT/CREB信号通路改善衰老小鼠记忆减退的机制研究
Rongqi Ma,Jiyu Gong,Xiaoyan Xie et al.
Rongqi Ma et al.
Black American Ginseng (Panax quinquefolium L.) is a traditional Chinese medicine taken orally. While saponins from American Ginseng are known to enhance memory, the effects and mechanisms of Black American Ginseng saponins remain unclear.T...
Protective effect of carvacrol in a cardiac myoblast cell model of myocardial ischemia-reperfusion injury [0.03%]
卡瓦油素对心肌缺血再灌注损伤细胞模型的保护作用
Ali M Albarrati,Rakan I Nazer
Ali M Albarrati
Phytopharmacology has become a key approach for developing new therapeutic strategies by utilizing the diverse bioactive properties of plant-derived compounds to treat complex diseases, including cardiovascular disorders.Myocardial ischemia...
Apigenin Derivatives as Promising Norovirus RdRp Inhibitors: Insights from In Silico Docking and Molecular Dynamics Studies [0.03%]
基于计算对接和分子动力学研究的木犀草素衍生物作为有前景的诺如病毒RdRp抑制剂
M D Sanober,Estari Mamidala
M D Sanober
Norovirus is a leading cause of acute gastroenteritis worldwide, yet no approved antivirals currently exist. In this study, we employed in silico approaches to evaluate apigenin derivatives as potential inhibitors of norovirus RNA-dependent...
Fluoxetine as an Antidepressant Agent Induces Directly Deleterious Effects on Rat Isolated Pancreatic Mitochondria: Ameliorative Role of Betanin [0.03%]
betanin对氟西汀诱导的分离培养的大鼠胰腺线粒体毒性作用的影响
Ahmad Salimi,Saleh Khezri,Amir Mohsen Azami et al.
Ahmad Salimi et al.
1.It has been shown that fluoxetine is cytotoxic on pancreatic beta-cells via induction of mitochondrial dysfunction and oxidative stress. We investigated the direct effect of fluoxetine on isolated pancreatic mitochondria and evaluate the ...
Analysis of the Therapeutic Potential of Astragalin: Insights into Target Interactions and Mechanisms [0.03%]
白桦素治疗潜力分析：靶点相互作用及机制研究启示
Hai Duc Nguyen
Hai Duc Nguyen
Astragalin (AST), a flavonoid, shows promise for neurodegenerative diseases like Parkinson's disease (PD), cognitive impairment (CI), and depression. However, its efficacy in treating neurodegenerative diseases and the underlying molecular ...
Aloe-emodin Regulates Colon Epithelial Cell Function by Regulating HIF-1α to Alleviate Irritable Bowel Syndrome [0.03%]
番红花黄素通过调节HIF-1α来调节结肠上皮细胞功能以缓解肠易激综合征
Qinghua Wang,Shiyu Lu,Zhonghao Yin
Qinghua Wang
1. This study aimed to investigate the therapeutic potential of Aloe-emodin (AE) for irritable bowel syndrome (IBS), focusing on its effects and underlying mechanisms.2. Deoxycholic acid (DCA)-induced IBS rats (Sprague-Dawley) were orally a...
Calycosin improves insulin resistance by regulating the hsa-miR-324-3p/AKT pathway to inhibit FOXO3a nuclear transfer [0.03%]
川萼茋通过调节hsa-miR-324-3p/AKT信号通路抑制FOXO3a核转位改善胰岛素抵抗
Junling Zhu,Rilian Lai,Qin Zheng et al.
Junling Zhu et al.
1. To study the effects of calycosin on palmitic acid-induced HepG2 cells, as well as the potential mechanisms of action.2. Potential targets of calycosin for the alleviation of insulin resistance were predicted by network pharmacology. Glu...
Permethrin disrupts antioxidant defense responses in Litopenaeus vannamei [0.03%]
苯氧威扰乱Litopenaeus vannamei抗氧化防御响应
Juliana Righetto Moser,Eliziane Silva,Maria Risoleta Freire Marques
Juliana Righetto Moser
Permethrin, a pyrethroid commonly used to grow crops worldwide, may contaminate the aquatic environment, as well as the ponds of shrimp farms, located in the vicinity of cultivated fields. We investigated the activity of antioxidant defense...