The protective effect of linalool against carbon tetrachloride-induced testicular toxicity in rats [0.03%]
苯甲醇对四氯化碳致大鼠睾丸毒性的保护作用
Mohammadreza Khalkhali,Shiva Rahimi,Aliakbar Fazaeli et al.
Mohammadreza Khalkhali et al.
Infertility related to men is a major global issue. Due to the high costs and side effects of chemical drugs, interest has shifted towards medicinal bioactive compounds. Linalool, a terpenoid found in many plants, shows potential in reducin...
Therapeutic effect of oleanolic acid on hyperthyroid rats through TLR4/NF-κB pathway [0.03%]
通过TLR4/NF-κB信号通路白桦酸对甲亢大鼠的治疗作用研究
Jian Zhong,Xiali Zhou,Jing Zhang et al.
Jian Zhong et al.
Hyperthyroidism is primarily characterized by excessive secretion of thyroid hormones and abnormal proliferation of thyroid follicular cells. Graves' disease is the most prevalent and is classified as an autoimmune thyroid disorder. However...
Model-Based Steady State Pharmacokinetic Predictions Using High Throughput Cassette Infusion Approach in Mice [0.03%]
基于模型的稳定状态药代动力学预测采用高通量嵌套式输液方法在小鼠中实现
Saivishal Daripelli,Amol Achyutrao Raje,Vishwottam Kandikere et al.
Saivishal Daripelli et al.
Achieving and characterizing steady-state drug concentrations is an essential objective for evaluating exposure-response relationships in preclinical pharmacology. This study assessed the pharmacokinetics (PK) of Fulvestrant, Imipramine, an...
Identification, structural elucidation and nonclinical characterization of oxMET1: A further major metabolite of xevinapant? [0.03%]
oxMET1的鉴定、结构阐明及非临床特征研究：依维尔潘坦的另一主要代谢产物？
Benedikt Lang,Hanno Schieferstein,Holger Scheible et al.
Benedikt Lang et al.
1. Xevinapant, an oral IAP (inhibitor of apoptosis protein) inhibitor, has been investigated in several clinical studies for the treatment of various cancers. In the course of the clinical pharmacology program, a novel circulating metabolit...
Effect of plantamajoside on the pharmacokinetics of nifedipine in rats and the underlying mechanisms [0.03%]
植物胺甲苷对尼群地平大鼠药动学影响及机制研究
Shaorong Huang,Fangwu Su,Meng Lei
Shaorong Huang
1. Plantamajoside was reported to possess blood pressure-lowering effects. This study explores how plantamajoside affects the pharmacokinetics of nifedipine, providing valuable insights for clinical drug use.2. This study examined the effec...
In Vitro Evaluation of Norwogonin as a Potential Inhibitor of Cytochrome P450 forms 3A4, 2D6, and 2C9 [0.03%]
穿心莲内酯体外评价作为细胞色素P450 3A4，2D6和2C9的潜在抑制剂
Xianjie He,Dong Zhang,Hui Chen
Xianjie He
1. Norwogonin, a bioactive flavonoid with anti-inflammatory and anticancer potential. Its interactions with cytochrome P450 enzymes remain uncharacterized. This study aimed to investigate the effect of norwogonin on the activity of P450s.2....
Behavioral Toxicodynamics and Kinetic profiling of PCB congeners in Swiss albino mouse dosed with Aroclor 1232 through inhalational route: A pivotal risk assessment study [0.03%]
通过吸入途径用Aroclor 1232染毒的瑞士白色小鼠品系多氯联苯同系物的行为毒性动力学及动力学特征评定：一项关键风险评估研究
Sivaselvakumar Muthusamy,Ramanujam Narayanan
Sivaselvakumar Muthusamy
Introduction: Polychlorinated Biphenyls pose hazards to humans as environmental and occupational workplace pollutants, despite which, though they are regulated in India, their use is not yet banned. ...
Impact of Terminalia ivorensis on drug metabolising and antioxidant enzyme activities, hepatotoxicity and genotoxicity in human liver cells in vitro [0.03%]
Terminalia ivorensis对人肝细胞中体外药酶、抗氧化酶活性、肝毒性和致突变性的影响
Aliu Moomin,Rachel M Knott,Wendy R Russell et al.
Aliu Moomin et al.
1.introduction: We previously reported the effects of Terminalia ivorensis on the proliferation, genomic instability and migration of human colon cancer cells. This study assessed the effect of T. ivorensis on hepatotoxic...
Fluorescent Dyes as Functional Probes for Studying Drug-Transporting Solute Carriers [0.03%]
荧光染料作为研究药物转运溶质载体的功能探针
Olivier Fardel,Amélie Moreau,Hélène Le Mentec et al.
Olivier Fardel et al.
1. Solute carrier (SLC) transporters are key players in drug pharmacokinetics and are notably involved in drug-drug interactions; their potential interactions with new molecular entities must be evaluated during pharmaceutical development f...
The Mitochondrial Protective Mechanisms Mediated by SGLT2i: From Molecular Basis to Clinical Implications [0.03%]
SGLT2i介导的线粒体保护机制：从分子机制到临床意义
Jianing Chen,Fengqi Wan,Kaiyue Wu et al.
Jianing Chen et al.
1. Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are a novel class of oral hypoglycemic agents that selectively inhibit glucose reabsorpt...