Cerebral ischemia-reperfusion induced cardiac injury in rats: involvement of oxidative stress, apoptosis, TLR4, NF-κB and HSP70: the rescue effect of losartan [0.03%]
脑缺血再灌注诱发大鼠心脏损伤：氧化应激、TLR4/NF-κB介导的炎症反应与HSP70及细胞凋亡的关系以及氯沙坦对其的干预作用
Yasaman Shakouri Msc of Physiology,Hamid Sorayya Associate Professor of Pharmacology,Roya Naderi Associate Professor of Physiology
Yasaman Shakouri Msc of Physiology
This study aimed to explore the effect of cerebral ischemia reperfusion and losartan on oxidative stress, inflammation, apoptosis and its molecular mediators in the rat heart. The groups were as follows (n = 6): 1) sham 2) ischemia-reperfus...
Prognostic Value of Circulating Tumor DNA Mutation Panels to Predict Early Recurrence and Survival Outcomes in Early-Stage Breast Cancer: A Systematic Review and Meta-Analysis [0.03%]
循环肿瘤DNA突变谱预测早期乳腺癌复发和生存的预后价值：系统评价和 meta 分析
Mohsin Ali,Muhammad Imran,Jawad Hussain et al.
Mohsin Ali et al.
Background: Early-stage breast cancer (BC) shows heterogeneous recurrence risk. Circulating tumor DNA (ctDNA) is promising non-invasive biomarker for minimal residual disease and recurrence prediction, though prognostic p...
Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease and Dementia in MCI: A Systematic Review and Robust Bayesian Meta-Analysis [0.03%]
血浆神经丝轻链和胶质纤维酸性蛋白预测MCI转为阿尔茨海默病及痴呆的诊断价值：系统评价与稳健贝叶斯荟萃分析
Çağrı Özkurt,Pelin Kelicen-Uğur
Çağrı Özkurt
Background: Accessible biomarkers to predict conversion to Alzheimer's disease and other dementias in Mild Cognitive Impairment (MCI) are urgently needed. Plasma neurofilament light (NfL) and glial fibrillary acidic prote...
Identification and Validation of Gene Markers for Early Detection and Prognosis in Colorectal Cancer: A Comprehensive RNA-Seq Based Approach [0.03%]
基于RNA-_seq的结直肠癌早期诊断和预后基因标记物的鉴定与验证：一种全面的方法
Xiaolin Qian,Bin Qian,Shanshan Wang et al.
Xiaolin Qian et al.
Background: Reliable molecular biomarkers are needed for early diagnosis of colorectal cancer (CRC). This study aimed to identify and validate a robust diagnostic gene signature for CRC using transcriptomic analysis. ...
Identification and validation of AFAP1L1 as an immune-related prognostic biomarker in clear cell renal cell carcinoma [0.03%]
AFAP1L1作为透明细胞肾细胞癌免疫相关预后生物标志物的鉴定与验证
Qiaoping Yan,Binbin Zhang,Yunhan Yu et al.
Qiaoping Yan et al.
Background: Clear cell renal cell carcinoma (ccRCC) accounts for over 75% of all renal cancer and contributes significantly to cancer-associated mortality. This study aims to identify a new ccRCC biomarker. ...
Evaluation of the protective effects of selenium against iron overload-induced toxicity in rats using a multiple-markers approach [0.03%]
采用多种标志物评价硒对铁过载致大鼠毒害的保护作用
Ateeqah Ghayth Alzwawy,Abdelhafidh Khazri,Ahmed Kouki et al.
Ateeqah Ghayth Alzwawy et al.
Background: Iron overload can promote the generation of reactive oxygen species (ROS), leading to oxidative stress and different human diseases. The trace element selenium has biological functions and can act as both an a...
Diagnostic significance of the combination of serum CCL20 and Oncostatin M for early-stage endometrial cancer [0.03%]
血清CCL20和Oncostatin M联合检测在早期子宫内膜癌诊断中的意义分析
Yuhua Wei,Xiaojuan Lv,Huan Tang et al.
Yuhua Wei et al.
Aim: Our study aimed to preliminarily investigate the role of combined detection of serum CCL20 and Oncostatin M in the diagnosis of early-stage endometrial cancer (EC). ...
Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and its association with select anxiety-related disorders: an updated systematic review and meta-analysis [0.03%]
脑源性神经营养因子基因Val66Met多态性与选择性焦虑谱系障碍的关联：最新系统综述和meta分析更新报告
Raphael Enrique Tiongco,Ma Agatha Anne Dizon,Neil David Cayanan et al.
Raphael Enrique Tiongco et al.
BACKGROUND: Conflicting results on the association of the Val66Met polymorphism in the BDNF gene with anxiety-related disorders are observed from previous studies and meta-analyses. We performed an updated meta-analysis to obtain more preci...
Early Impact of Lenvatinib on Liver Function and its Prognostic Significance: A Single-Center Retrospective Study [0.03%]
仑伐替尼对肝功能早期影响及其预后意义的单中心回顾性研究
Pei Wang,Shuheng Liu,Xiaoxia Lu
Pei Wang
Objective: Lenvatinib shows efficacy for tumor response and survival in patients with advanced hepatocellular carcinoma (HCC). We aim to assess the effect of lenvatinib on liver function. ...
Identification of a potential relationship between pigmented villonodular synovitis and atherosclerosis using comprehensive bioinformatics analyses [0.03%]
利用全面的生物信息学分析识别色素沉着性绒毛结节性滑膜炎与动脉粥样硬化之间潜在关系
Shuilin Chen,Honglei Jia,Guihao Zheng et al.
Shuilin Chen et al.
Background: This study investigates the pathogenesis of Pigmented Villonodular Synovitis (PVNS) using bioinformatics approaches shared with atherosclerosis (AS). ...