Circulating microRNA-21 (MIR-21) and phosphatase and tensin homolog (PTEN) are promising novel biomarkers for detection of oral squamous cell carcinoma [0.03%]
循环miR-21（MIR-21）和磷酯酶和张力蛋白同源物（PTEN）是诊断口腔鳞状细胞癌极具潜力的新型生物标志物
WenHao Ren,Cui Qiang,Ling Gao et al.
WenHao Ren et al.
The purpose of this study was to investigate the potential of the blood levels of MIR-21 and PTEN as novel biomarkers for oral squamous cell carcinoma (OSCC). We initially detected MIR-21 and PTEN using real-time RT-PCR from 90 blood sample...
Ananília Medeiros Gomes da Silva,Vivian Nogueira Silbiger
Ananília Medeiros Gomes da Silva
Atrial fibrillation (AF) is a highly prevalent arrhythmia with pronounced morbidity and mortality. Genetics analysis has established electrophysiological substrates, which determine individual vulnerability to AF occurrence and maintenance....
Urinary messenger RNA of the receptor activator of NF-kappaB could be used to differentiate between minimal change disease and membranous nephropathy [0.03%]
NF-κB受体活化剂尿液mRNA用于鉴别微小病变和膜性肾病的价值
Shuangxin Liu,Ping Mei,Wei Shi et al.
Shuangxin Liu et al.
Podocyte damage and loss together have an important role in the pathogenesis and progression of glomerulonephritis. Glomerulonephritis patients and healthy controls were enrolled in this study. Biochemical, clinical and experimental procedu...
Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run [0.03%]
半程马拉松赛后血液循环中miR-1、miR-133a和miR-206水平升高
Clarissa P C Gomes,Getúlio P Oliveira Jr,Bibiano Madrid et al.
Clarissa P C Gomes et al.
Context: Circulating miRNAs are potential biomarkers that can be important molecules driving cell-to-cell communication. Objective: To ...
Betaine homocysteine methyltransferase (BHMT) as a specific and sensitive blood marker for acute liver injury [0.03%]
蛋氨酸同型半胱氨酸甲基转移酶（BHMT）作为急性肝损伤的特异性血清标志物
Huailei Ma,Jing Ning,Xin Jin et al.
Huailei Ma et al.
We developed a high-performance ELISA assay and measured serum BHMT levels in healthy individuals and patients with acute liver injury (ALI). The detection range of this ELISA assay was from 1.56 to 100 ng/ml. BHMT levels are significantly ...
Zheng Wu,Dan Zhu
Zheng Wu
Catestatin (CST) was first discovered as a potent non-competitive and reversible inhibitor of catecholamine secretion. Recent reports on plasma CST level in heart diseases suggested a cardioprotective role for this peptide. Given that cardi...
Is cerebrospinal fluid obtained for diagnostic purpose a good material for biomarker studies in amyotrophic lateral sclerosis? [0.03%]
脑脊液作为诊断目的的获取样本是否适合用于肌萎缩侧索硬化症生物标志物研究？
Beata Chełstowska,Magdalena Kuźma-Kozakiewicz
Beata Chełstowska
The cerebrospinal fluid (CSF) used for identification of molecular biomarkers in amyotrophic lateral sclerosis (ALS) is mainly obtained from lumbar puncture (LP) performed to exclude other causes of motor neuron damage. ...
A novel cost-effective assay based on real-time PCR for COMT Val158Met genotyping [0.03%]
一种基于实时定量PCR的COMT Val158Met基因分型新方法及其应用效果评价
Diego A Ojeda,Sandra López-León,Diego A Forero
Diego A Ojeda
A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) has been associated with a large number of human diseases and endophenotypes. The aim of this study was to develop a novel cost-effective assay to genotyp...
EGF rs11568835 G/A polymorphism is associated with increased risk of rheumatoid arthritis [0.03%]
表皮生长因子rs11568835G/A多态性与增加类风湿关节炎风险有关
Liqun Wang,Lin Bo,Ting Yan et al.
Liqun Wang et al.
Rheumatoid arthritis (RA) is an autoimmune rheumatological disease thought to have substantial genetic contributions. Epidermal growth factor (EGF) can activate DNA synthesis and cellular proliferation. Early RA synovial fluid was character...
Polymorphism of DNA repair genes OGG1, XRCC1, XPD and ERCC6 in bladder cancer in Belarus [0.03%]
白俄罗斯膀胱癌患者DNA修复基因OGG1、XRCC1、XPD和ERCC6多态性研究
Volha P Ramaniuk,Nataliya V Nikitchenko,Nataliya V Savina et al.
Volha P Ramaniuk et al.
Context: The study of DNA base and nucleotide excision repair gene polymorphisms in bladder cancer seems to have a predictive value because of the evident relationship between the DNA damage response induced by environmen...