Chimeric Epitope Vaccine from Multistage Antigens for Lymphatic Filariasis [0.03%]
淋巴丝虫病的多阶段抗原嵌合表位疫苗
G Anugraha,J Madhumathi,P R Prince et al.
G Anugraha et al.
Lymphatic filariasis, a mosquito-borne parasitic disease, affects more than 120 million people worldwide. Vaccination for filariasis by targeting different stages of the parasite will be a boon to the existing MDA efforts of WHO which requi...
IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses [0.03%]
IRF4缺陷通过增强PI3K途径、降低SHIP表达和破坏细胞骨架反应导致BCR信号转导异常
P M Budzyńska,M Niemelä,A V Sarapulov et al.
P M Budzyńska et al.
The graded expression of transcription factor interferon regulatory factor 4 (IRF4) regulates B cell development and is critical for plasma cell differentiation. However, the mechanisms, by which IRF4 elicits its crucial tasks, are largely ...
TGFB1 Functional Gene Polymorphisms (C-509T and T869C) in the Maternal Susceptibility to Pre-eclampsia in South Indian Women [0.03%]
转化生长因子B1功能基因多态性（C-509T和T869C）与南印度妇女子痫前期易感性的关系研究
Goske Deepthi,Ponnaluri Kamakshi Chaithri,Prasanna Latha et al.
Goske Deepthi et al.
Pre-eclampsia (PE), a pregnancy-specific vascular disorder characterized by hypertension and proteinuria, is hypothesized to be the result of inadequate placental angiogenesis with attendant systemic inflammation. The pleiotropic cytokine, ...
Genomewide Histone H3 Lysine 9 Acetylation Profiling in CD4+ T Cells Revealed Endoplasmic Reticulum Stress Deficiency in Patients with Acute-on-chronic Liver Failure [0.03%]
外显子组泛基因组组蛋白H3赖氨酸9乙酰化谱在急性-on-慢性肝功能衰竭患者CD4⁺T细胞中的内质网应激缺陷研究
L Jin,K Wang,H Liu et al.
L Jin et al.
Acute-on-chronic liver failure (ACLF) displayed 'sepsis-like' immune paralysis. Little is known about the role of CD4+ T lymphocytes, the primary regulator of innate and adopted immune system, played in ACLF. Acetylation of histone H3 lysin...
Comparative Study
Scandinavian journal of immunology. 2015 Nov;82(5):452-9. DOI:10.1111/sji.12341 2015
CD21 -/low B cells: A Snapshot of a Unique B Cell Subset in Health and Disease [0.03%]
CD21低表达B细胞：健康与疾病下独特B细胞亚群的快照
K Thorarinsdottir,A Camponeschi,I Gjertsson et al.
K Thorarinsdottir et al.
B cells represent one of the cellular components of the immune system that protects the individual from invading pathogens. In response to the invader, these cells differentiate into plasma cells and produce large amounts of antibodies that...
New Insights and Biomarkers for Type 1 Diabetes: Review for Scandinavian Journal of Immunology [0.03%]
第1型糖尿病的新见解和生物标志物： Scandinavian Journal of Immunology综述
M T Heinonen,R Moulder,R Lahesmaa
M T Heinonen
The increasing incidence of type 1 diabetes observed in the past 60 years has spawned massive efforts in multiple research fields to elucidate the aetiology of this disease. While GWAS studies provide a good genetic basis for the current kn...
M Lettau,D Kabelitz,O Janssen
M Lettau
Lysosome-related secretory organelles combine metabolic functions of conventional lysosomes with an inducible secretory potential. Specialized variants of such bi-functional organelles are present in several haematopoietic cell types that s...
Regulation of B Cell to Plasma Cell Transition within the Follicular B Cell Response [0.03%]
生发中心B细胞反应中调控B细胞向浆细胞的转变
K-P Nera,M K Kyläniemi,O Lassila
K-P Nera
Persistent humoral immunity depends on the follicular B cell response and on the generation of somatically mutated high-affinity plasma cells and memory B cells. Upon activation by an antigen, cognately activated follicular B cells and foll...
The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link? [0.03%]
细胞死亡在SLE发病机制中的作用：Pyroptosis是缺失的环节吗？
M Magna,D S Pisetsky
M Magna
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with systemic inflammation and organ damage. In addition to genetic factors, a contributio...
A Berglöf,A Hamasy,S Meinke et al.
A Berglöf et al.
Ibrutinib (Imbruvica™) is an irreversible, potent inhibitor of Bruton's tyrosine kinase (BTK). Over the last few years, ibrutinib has developed from a promising drug candidate to being approved by FDA for the treatment of three B cell mali...