Effect of Lipopolysaccharide on the Progression of Non-Alcoholic Fatty Liver Disease in High Caloric Diet-Fed Mice [0.03%]
脂多糖通过调节肠道菌群对高热量饮食小鼠非酒精性脂肪肝病进展的影响
N Matsushita,T Osaka,I Haruta et al.
N Matsushita et al.
The incidence of non-alcoholic steatohepatitis (NASH) is increasing. Because gut microbiota have been highlighted as one of the key factors in the pathogenesis of metabolic syndrome, we investigated the involvement of the bacterial componen...
Neutralization of Interleukin-17 Attenuates Cholestatic Liver Fibrosis in Mice [0.03%]
中性化白细胞介素-17可减轻小鼠胆汁淤积性肝纤维化
S Zhang,D Huang,J Weng et al.
S Zhang et al.
Anti-inflammation strategy is one of the proposed therapeutic approaches to hepatic fibrosis. IL-17 is critical in inflammation, but the role of IL-17 in liver fibrosis has not yet been elucidated. In this study, we investigate the role of ...
Interleukin-21 Induces Proliferation and Proinflammatory Cytokine Profile of Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis [0.03%]
白细胞介素-21诱导类风湿关节炎患者的滑膜成纤维样细胞增殖和促炎症细胞因子谱型
R Xing,L Yang,Y Jin et al.
R Xing et al.
Fibroblast-like synoviocytes (FLS) play a pivotal role in the pathogenesis of rheumatoid arthritis (RA) through aggressive proliferation and invasion, and certain proinflammatory cytokines may affect synoviocyte proliferation. To evaluate w...
Immunization of Mice with a Live Transconjugant Shigella Hybrid Strain Induced Th1 and Th17 Cell-Mediated Immune Responses and Confirmed Passive Protection Against Heterologous Shigellae [0.03%]
活转位子志贺菌杂交毒株使小鼠免疫诱导Th1和Th17细胞介导的免疫应答并确证了对异质性志贺氏菌的被动保护作用
D Nag,H Koley,R Sinha et al.
D Nag et al.
An avirulent, live transconjugant Shigella hybrid (LTSHΔstx) strain was constructed in our earlier study by introducing a plasmid vector, pPR1347, into a Shiga toxin gene deleted Shigella dysenteriae 1. Three successive oral administration...
L Yang,Y Guo,D Wen et al.
L Yang et al.
Traumatic brain injury (TBI) is one of the leading causes of mortality and morbidity in young individuals worldwide. However, the understanding of TBI at secondary phase remained obscure, and more knowledge of the pathophysiology of TBI is ...
Sclerostin, TNF-alpha and Interleukin-18 Correlate and are Together with Klotho Related to Other Growth Factors and Cytokines in Haemodialysis Patients [0.03%]
血透患者中硬化素、TNF-α和IL-18的相关性及其与类克托勒因子和其他细胞因子之间的关系
G Almroth,J Lönn,F Uhlin et al.
G Almroth et al.
Patients with chronic renal failure are known to have renal osteodystrophy (bone disease) and increased calcification of vessels. A new marker of bone disease, sclerostin, the two pro-inflammatory cytokines tumour necrosis factor-alpha (TNF...
Identification of Suitable Reference Genes for Peripheral Blood Mononuclear Cell Subset Studies in Multiple Sclerosis [0.03%]
多发性硬化外周血单核细胞亚群研究中合适参考基因的鉴定
D B Oturai,H B Søndergaard,L Börnsen et al.
D B Oturai et al.
Quantitative real-time PCR (qPCR) involves the need of a proper standard for normalizing the gene expression data. Different studies have shown the validity of reference genes to vary greatly depending on tissue, cell subsets and experiment...
Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis [0.03%]
慢性疲劳综合症/肌痛性脑脊髓炎和多发性硬化中自然杀伤细胞的研究初探
T K Huth,E W Brenu,S Ramos et al.
T K Huth et al.
Patients with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and multiple sclerosis (MS) suffer from debilitating fatigue which is not alleviated by rest. In addition to the fatigue-related symptoms suffered by patients with CF...
HLA-G 14-bp Ins/Ins Genotype in Patients Harbouring Helicobacter pylori Infection: A Potential Risk Factor? [0.03%]
Helicobacter pylori感染患者的HLA-G 14-bp Ins/Ins基因型：一个潜在的风险因素吗？
J Genre,F P Santos Reginaldo,J Marco de Leon Andrade et al.
J Genre et al.
H. pylori is a potent pathogen due to its capacity to successfully evade host defence mechanisms. Despite inducing immune responses in infected individuals, sometimes these responses fail to clear the infection and the bacterium establishes...
H Kääriö,J K Nieminen,A M Karvonen et al.
H Kääriö et al.
Farm environment has been shown to protect from childhood asthma. Underlying immunological mechanisms are not clear yet, including the role of dendritic cells (DCs). The aim was to explore whether asthma and farm exposures are associated wi...