Novel Human Three-Domain Antibody Fragments Against sTNFα as Well as tmTNFα with High Affinity Generated by the Combination of Ribosome Display and E. coli Expression System [0.03%]
一种新型人三域抗体片段可同时高亲和力结合可溶型及跨膜型TNF-alpha：核糖体展示技术和大肠杆菌表达系统相结合的产物
X-L Zhao,L-F Tian,S-J Zhang et al.
X-L Zhao et al.
Human tumour necrosis factor α (hTNFα) has been proved to be a validated therapeutic target in a number of immune-mediated inflammatory diseases (IMIDs). Fully human monoclonal antibodies (mAbs) that can neutralize soluble hTNFα (sTNFα)...
Alteration of Polymeric Immunoglobulin Receptor and Neonatal Fc Receptor Expression in the Gut Mucosa of Immunodeficiency Virus-Infected Rhesus Macaques [0.03%]
免疫缺陷病毒感染的恒河猴肠道粘膜聚免疫球蛋白受体和新生儿Fc受体表达改变
Y Wang,G B Yang
Y Wang
Polymeric immunoglobulin receptors (pIgR) and neonatal Fc receptors (FcRn) are crucial immunoglobulin (Ig) receptors for the transcytosis of immunoglobulins, that is IgA, IgM and IgG, the levels of which in mucosal secretions were altered i...
M Cohn
M Cohn
Any analysis of the mechanism of signalling during positive selection in the thymus is dependent on one's model of the TCR-ligand interaction. To date, thinking about mechanism has been dominated by what might be termed the Standard (or Cen...
S Avrameas
S Avrameas
In this review, we summarize and discuss some key findings from the study of naturally occurring autoantibodies. The B-cell compartment of the immune system appears to recognize almost all endogenous and environmental antigens. This ability...
R Valiathan,M Ashman,D Asthana
R Valiathan
Physiological ageing is accompanied by decline in immune system function and immune alteration during ageing increases susceptibility to infections. We retrospectively analysed the data for complete blood count (CBC) and lymphocyte subsets ...
B Dyring-Andersen,M M Nielsen,C Geisler et al.
B Dyring-Andersen et al.
S Thordardottir,T Vikingsdottir,H Bjarnadottir et al.
S Thordardottir et al.
The aim of this study was to investigate whether complement activation, via the classical and alternative pathways, occurs following a cemented total hip replacement (THR) surgery due to osteoarthritis. Blood samples were collected systemat...
Vaccine-Induced Antibody Responses Prevent the Induction of Interferon Type I Responses Upon a Homotypic Live Virus Challenge [0.03%]
疫苗诱导的抗体反应可以防止同源活病毒攻击引发I型干扰素反应
J Chan,R Babb,S C David et al.
J Chan et al.
During acute viral infections, innate immunity provides essential protective measures to minimize virus dissemination and regulate adaptive immunity. This helps to successfully eliminate the pathogen and establish long-term memory. Here, we...
Investigation of Cytotoxic T-lymphocyte antigen 4 Polymorphisms in Gastric Cardia Adenocarcinoma [0.03%]
胃贲门腺癌中细胞毒T淋巴细胞相关抗原4多态性的研究
W Tang,Y Wang,S Chen et al.
W Tang et al.
To assess the potential effects of Cytotoxic T-lymphocyte antigen 4 (CTLA4) gene polymorphisms on susceptibility to gastric cardia adenocarcinoma (GCA), we genotyped four polymorphisms (rs733618 A>G, rs16840252 C>T, rs231775 G>A and rs30872...
Blockade of Interleukin-17 Restrains the Development of Acute Lung Injury [0.03%]
阻断白细胞介素-17限制急性肺损伤的发展
Q Li,Y Gu,Q Tu et al.
Q Li et al.
The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill patients. Here, we explored the association between IL-17 a...