A Corthay
A Corthay
The immune system may seem incredibly complex. Researchers in immunology are amassing enormous amounts of detailed information without gaining proportional insights. Why might this be? So asks Peter Bretscher near the start of his book Redi...
Genetic Variants in IL-12B and IL-27 in the Polish Patients with Systemic Lupus Erythematosus [0.03%]
波兰系统性红斑狼疮患者IL-12B和IL-27基因变异的研究
A Paradowska-Gorycka,A Sowinska,B Stypinska et al.
A Paradowska-Gorycka et al.
To investigate the potential association between IL-12B and IL-27 gene polymorphisms and systemic lupus erythematosus (SLE), we performed a case-control study based on the Polish population. Patients with SLE and healthy individuals were ex...
The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains [0.03%]
ZAP-70中的SKG突变也能使C57BL小鼠系易患关节炎
S Guerard,M Boieri,M Hultqvist et al.
S Guerard et al.
Various rodent models of arthritis are essential to dissect the full complexity of human rheumatoid arthritis (RA), a common autoimmune disease affecting joints. The SKG model of arthritis originates from a spontaneous mutation in ZAP-70 fo...
MICA, MICB Polymorphisms and Linkage Disequilibrium with HLA-B in a Chinese Mongolian Population [0.03%]
中国蒙古族人群中MICA、MICB多态性和与HLA-B的连锁不平衡研究
W Y Wang,W Tian,F M Zhu et al.
W Y Wang et al.
In this study, polymorphisms of major histocompatibility complex class I chain-related genes A and B (MICA and MICB) and human leucocyte antigen (HLA)-B gene were investigated for 158 unrelated Chinese Mongolian subjects recruited from cent...
Identification of Biological and Pharmaceutical Mast Cell- and Basophil-Related Targets [0.03%]
生物和药物方面的 mast 细胞和 basophil 相关目标的识别
O Klein,F Ngo-Nyekel,T Stefanache et al.
O Klein et al.
HIV-infected CD4+ T Cells Use T-bet-dependent Pathway for Production of IL-10 Upon Antigen Recognition [0.03%]
HIV感染的CD4+T细胞在识别抗原后通过T-bet依赖性途径产生IL-10
A Shete,P Suryawanshi,S Godbole et al.
A Shete et al.
Interleukin (IL)-10 has been implicated in persistence of pathogens in a number of chronic infections. Infected CD4+ cells upon reactivation with HIV antigens were also shown to produce IL-10, which might contribute to their persistence. He...
Healthy Preterm Newborns Show an Increased Frequency of CD4(+) CD25(high) CD127(low) FOXP3(+) Regulatory T Cells with a Naive Phenotype and High Expression of Gut-Homing Receptors [0.03%]
健康早产新生儿表现出具有初始表型和高表达肠道归巢受体的CD4(+) CD25(hi) CD127(lo) FOXP3(+)调节性T细胞的频率增加
C Rennó,M I V Nadaf,C A Zago et al.
C Rennó et al.
Treg cells are crucial to prevent immune dysregulation, but little is known about the frequency of these cells in neonates, particularly in very/moderate and late preterm newborns studied as separate groups. The CD4(+) CD25(hi) CD127(lo) FO...
Changes in the Immune System of Female Wistar Rats After Exposure to Immunosuppressive Treatment During Pregnancy [0.03%]
免疫抑制治疗对妊娠威斯特大鼠免疫系统的影响研究
J Kabat-Koperska,A Kolasa-Wołosiuk,B Wojciuk et al.
J Kabat-Koperska et al.
This experimental study assessed the impact of medications frequently used after kidney transplantation on the immune system of pregnant female Wistar rats. The study evaluates medications, both approved and contraindicated during pregnancy...
Tumour-Associated Autoantibodies as Diagnostic Biomarkers for Breast Cancer: A Systematic Review and Meta-Analysis [0.03%]
乳腺癌相关自身抗体作为诊断生物标志物的系统评价和 meta 分析
J Xia,J Shi,P Wang et al.
J Xia et al.
Tumour-associated autoantibodies may be promising biomarkers that could facilitate breast cancer (BC) diagnosis and improve patient outcomes. This review aims to identify the tumour-associated autoantibodies with the greatest diagnostic pot...
Is the Framework of Cohn's 'Tritope Model' for How T Cell Receptors Recognize Peptide/Self-MHC Complexes and Allo-MHC Plausible? [0.03%]
科恩的“三顶点模型”框架能否解释T细胞受体如何识别肽/自身MHC和异体MHC复合物？
Peter A Bretscher
Peter A Bretscher
Cohn has developed the tritope model to describe how distinct domains of the T cell receptor (TcR) recognize peptide/self-MHC complexes and allo-MHC. He has over the years employed this model as a framework for considering how the TcR might...