Correlation of Serum Vitamin A Levels with Disease Activity Indices and Colonic IL-23R and FOXP3 mRNA Expression in Ulcerative Colitis Patients [0.03%]
溃疡性结肠炎患者血清维生素A水平与疾病活动指数及结肠IL-23R和FOXP3 mRNA表达的相关性研究
P Verma,S Subodh,V Tiwari et al.
P Verma et al.
Genome-wide association studies have identified IL-23 receptor (IL-23R) as a susceptibility locus for the pathogenesis of ulcerative colitis (UC), which is characterized by exaggerated Th2/Th17 response. Studies have shown that vitamin A (V...
Observational Study
Scandinavian journal of immunology. 2016 Aug;84(2):110-7. DOI:10.1111/sji.12450 2016
Autoantibody Specificities and Type I Interferon Pathway Activation in Idiopathic Inflammatory Myopathies [0.03%]
特发性炎性肌病中的自身抗体特异性和I型干扰素通路激活
L Ekholm,S Vosslamber,A Tjärnlund et al.
L Ekholm et al.
Myositis is a heterogeneous group of autoimmune diseases, with different pathogenic mechanisms contributing to the different subsets of disease. The aim of this study was to test whether the autoantibody profile in patients with myositis is...
Comparative Study
Scandinavian journal of immunology. 2016 Aug;84(2):100-9. DOI:10.1111/sji.12449 2016
Role of Eosinophil Granulocytes in Allergic Airway Inflammation Endotypes [0.03%]
嗜酸性粒细胞在过敏性气道炎症表型中的作用
K Amin,C Janson,J Bystrom
K Amin
Eosinophil granulocytes are intriguing members of the innate immunity system that have been considered important defenders during parasitic diseases as well as culprits during allergy-associated inflammatory diseases. Novel studies have, ho...
Early Secreted Antigenic Target of 6 kDa of Mycobacterium tuberculosis Stimulates Macrophage Chemoattractant Protein-1 Production by Macrophages and Its Regulation by p38 Mitogen-Activated Protein Kinases and Interleukin-4 [0.03%]
结核分枝杆菌早期分泌抗原靶标6kDa刺激巨噬细胞产生巨噬细胞趋化因子-1及其调节作用于p38丝裂酶活化蛋白激酶和白细胞介素-4
J Ma,B-G Jung,N Yi et al.
J Ma et al.
Early secreted antigenic target of 6 kDa (ESAT-6), the major virulence factor of Mycobacterium tuberculosis, affects host immunity and the formation of granulomas likely through inflammatory cytokines. To understand its role in this regard ...
Effects of Anti-CD45RB Monoclonal Antibody for T Lymphocyte Subsets in Mice Heart Transplantation Model [0.03%]
抗CD45RB单克隆抗体对小鼠心脏移植模型T淋巴细胞亚群的影响
C-Y Deng,X-F Wang,H Qi et al.
C-Y Deng et al.
Anti-CD45RB monoclonal antibody (anti-CD45RBmAb), as a new immune tolerance inducer, may inhibit T cell proliferation and induce immune tolerance through competitive combination with CD45RB on the T cell surface, which blocks the conduction...
MBL2 Genetic Variants in HCV Infection Susceptibility, Spontaneous Viral Clearance and Pegylated Interferon Plus Ribavirin Treatment Response [0.03%]
HCV感染易感性、自发病毒清除及聚乙二醇干扰素联合利巴韦林治疗应答中的MBL2基因多态性研究
L Zupin,V Polesello,G Alberi et al.
L Zupin et al.
Hepatitis C is disease that damages the liver, and it is caused by the hepatitis C virus (HCV). The pathology became chronic in about 80% of the cases due to virus persistence in the host organism. The standard of care consists of pegylated...
Antiphospholipid Antibodies are Associated with Low Levels of Complement C3 and C4 in Patients with Systemic Lupus Erythematosus [0.03%]
抗磷脂抗体与系统性红斑狼疮患者补体C3和C4低水平有关
L Garabet,I-M Gilboe,M-C Mowinckel et al.
L Garabet et al.
Complement activation and low complement levels are common in systemic lupus erythematosus (SLE). Antiphospholipid antibodies (aPL) are found in about 30-40% of patients with SLE. This study aimed to investigate the association between aPL ...
VH and VL Domains of Polyspecific IgM and Monospecific IgG Antibodies Contribute Differentially to Antigen Recognition and Virus Neutralization Functions [0.03%]
多特异性和单特异性抗体的VH和VL结构域对识别抗原和中和病毒功能具有不同的贡献性研究
Y Pasman,A K Kaushik
Y Pasman
We analysed contributions of variable heavy (FdVH ) and variable light (FdVL ) domains in comparison to scFv (FdVH +FdVL ) of naturally occurring polyspecific bovine IgM with an exceptionally long CDR3H and an induced monospecific bovine he...
Comparative Study
Scandinavian journal of immunology. 2016 Jul;84(1):28-38. DOI:10.1111/sji.12443 2016
Investigation on Immunomodulatory Activity of Calf Spleen Extractive Injection in Cyclophosphamide-induced Immunosuppressed Mice and Underlying Mechanisms [0.03%]
牛脾提取物注射液的免疫调节活性及机制研究
D Jia,W Lu,C Wang et al.
D Jia et al.
Calf spleen extractive injection (CSEI), extracted from the spleen of healthy cows (within 24 h of birth), is a small peptides enriched extraction while the ratio between peptide and ribose is 76 ± 15.2 mg/μg. CSEI is usually used as an a...
Oligomerization of Mannan-binding Lectin Dictates Binding Properties and Complement Activation [0.03%]
甘露聚糖结合凝集素的寡聚化决定了其结合特性及补体激活作用
T R Kjaer,L Jensen,A Hansen et al.
T R Kjaer et al.
The complement system is a part of the innate immune system and is involved in recognition and clearance of pathogens and altered-self structures. The lectin pathway of the complement system is initiated when soluble pattern recognition mol...