Guglielmo Lucchese,Angela Stufano
Guglielmo Lucchese
Plasmodium and Host Immunity: Evasion Strategies and Advances in Malaria Vaccination [0.03%]
疟原虫与宿主免疫系统：逃避策略及疟疾疫苗研发进展
Héctor Serrano-Coll,Lucero Katherine Aristizábal-Parra
Héctor Serrano-Coll
Malaria is an infectious disease caused by parasites of the Plasmodium genus. Its pathophysiology is highly complex, as it depends both on the host's immune response and the parasite's evasion mechanisms, which are often species-specific. T...
The Fusion Protein MuSK-Fc Functions as a Decoy to Block the Binding of Anti-MuSK Antibodies to MuSK [0.03%]
融合蛋白MuSK-Fc用作诱饵以阻断抗MuSK抗体与MuSK的结合
Akiyuki Uzawa,Hiroyuki Akamine,Manato Yasuda et al.
Akiyuki Uzawa et al.
Muscle-specific tyrosine kinase antibody-positive myasthenia gravis (MuSKMG) is a rare subtype of MG that is often more refractory to immune treatment than acetylcholine receptor (AChR) antibody-positive MG. Therefore, novel therapeutic str...
Najla Ghrairi,Youssef Zied Elhechmi
Najla Ghrairi
Allergic asthma is a chronic inflammatory airway disease characterised by airway hyperresponsiveness, reversible airflow obstruction and chronic inflammation. Environmental allergens trigger a series of immune responses driven by a Th2-domi...
Inhibition of Alternative and Terminal Complement Pathway Components Modulate the Immune Response Against Bacteria and Fungi in Whole Blood [0.03%]
补体系统的替代和末端途径成分的抑制作用调节了全血中的细菌及真菌诱导的免疫反应
Leon Cyranka,Ida Mariegaard,Beatrice Fageräng et al.
Leon Cyranka et al.
Complement activation plays a critical role in the inflammatory response to Escherichia coli and Aspergillus fumigatus conidia. However, the specific contributions of complement components, including anaphylatoxin receptors, remain unclear....
Yifan Xie,Qi Cheng,Meng Li Xu et al.
Yifan Xie et al.
Itaconate is a metabolite of the Krebs cycle, and endogenous itaconate is driven by a variety of innate signals that inhibit the production of inflammatory cytokines. The key mechanism of action of itaconate was initially found to be the co...
Fatigue in Inflammatory Bowel Disease: No Effect of Serum Concentrations of Infliximab, Adalimumab or Anti-Drug Antibodies During Maintenance Therapy [0.03%]
维持治疗期间类风湿患者英夫利昔、阿达木单抗及抗药抗体的血清浓度与炎症性肠病疲劳无关
Tore Grimstad,Arne Carlsen,Jan Terje Kvaløy et al.
Tore Grimstad et al.
Several studies have shown that infliximab and adalimumab ameliorate fatigue in inflammatory bowel disease. We investigated whether serum levels of these agents above or below a selected threshold influence fatigue severity. In this cross-s...
Upregulation of Fcγ Receptor IV on Activated Monocytes and Macrophages Causes Nonspecific Binding of the PK136 Anti-NK1.1 Antibody in Murine Models of Toll-Like Receptor-Induced Inflammation [0.03%]
TLR诱导的小鼠炎症模型中活化单核细胞和巨噬细胞上的Fcγ IV受体上调导致PK136抗NK1.1抗体的非特异性结合
Amber De Visscher,Marte Vandeput,Bert Malengier-Devlies et al.
Amber De Visscher et al.
Nonspecific binding of monoclonal antibodies to Fcγ receptors (FcγRs) is a well-known root cause of unreliable results in flow cytometry. Over the past decade, liver Group 1 innate lymphoid cells (ILCs), including conventional natural kil...
Evaluation of the Impact of Anti-C1q Autoantibodies on Cardiovascular Outcomes in Systemic Lupus Erythematosus [0.03%]
抗C1q抗体对系统性红斑狼疮患者心血管预后影响的评估研究
Jessica S Kleer,Andrea Kieninger-Gräfitsch,Carlo Chizzolini et al.
Jessica S Kleer et al.
Cytokine Expression and Cytolytic Effect of Natural Killer Cells are Suppressed in Septic Shock [0.03%]
脓毒性休克患者的NK细胞细胞因子表达和细胞毒效应受到抑制
Fengying Jie,Fang Dong,Lingwen Xu et al.
Fengying Jie et al.
Septic shock is the most severe stage of sepsis. How immune dysregulation contributes to the pathogenesis of septic shock has not been thoroughly understood. In the current research, the phenotype and function of circulating natural killer ...