Human Secretory IgM Antibodies Activate Human Complement and Offer Protection at Mucosal Surface [0.03%]
人类分泌型IgM抗体活化补体并提供黏膜表面保护作用
T E Michaelsen,S Emilsen,R H Sandin et al.
T E Michaelsen et al.
IgM molecules circulate in serum as large polymers, mainly pentamers, which can be transported by the poly-Ig receptor (pIgR) across epithelial cells to mucosal surfaces and released as secretory IgM (SIgM). The mucosal SIgM molecules have ...
G Azizi,V Ziaee,M Tavakol et al.
G Azizi et al.
Primary immunodeficiency diseases (PIDs) consist of a genetically heterogeneous group of immune disorders that affect distinct elements of the immune system. PID patients are more prone to infections and non-infectious complications, partic...
T Cell Responses and Regulation and the Impact of In Vitro IL-10 and TGF-β Modulation During Treatment of Active Tuberculosis [0.03%]
IL-10和TGF-β体外调节对活动性结核病治疗过程中T细胞反应和调节的影响
S L Feruglio,D Kvale,A M Dyrhol-Riise
S L Feruglio
Mycobacterium tuberculosis (Mtb) is particularly challenging for the immune system being an intracellular pathogen, and a variety of T cell subpopulations are activated by the host defence mechanism. In this study, we investigated T cell re...
Equine Airway Mast Cells are Sensitive to Cell Death Induced by Lysosomotropic Agents [0.03%]
马气道肥大细胞对溶酶体药物诱导的细胞死亡敏感
S Wernersson,M Riihimäki,G Pejler et al.
S Wernersson et al.
Mast cells are known for their detrimental effects in various inflammatory conditions. Regimens that induce selective mast cell apoptosis may therefore be of therapeutic significance. Earlier studies have demonstrated that murine- and human...
Participation of TLR2 and TLR4 in Cytokines Production by Patients with Symptomatic and Asymptomatic Chronic Chagas Disease [0.03%]
TLR2和TLR4在有症状及无症状慢性查加斯病患者细胞因子产生中的作用参与
L D Mendes da Silva,M Gatto,M Miziara de Abreu Teodoro et al.
L D Mendes da Silva et al.
Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is a serious public health issue. Its evolution involves an acute stage, characterized by no specific symptoms, and the chronic stage during most individuals are asymptomatic, ...
Therapeutic Potential for Targeting the Suppressor of Cytokine Signalling-1 Pathway for the Treatment of SLE [0.03%]
细胞因子信号抑制物-1通路的治疗潜能在系统性红斑狼疮中的应用研究进展
B Sukka-Ganesh,J Larkin rd
B Sukka-Ganesh
Although the specific events dictating systemic lupus erythematosus (SLE) pathology remain unclear, abundant evidence indicates a critical role for dysregulated cytokine signalling in disease progression. Notably, the suppressor of cytokine...
Selective IgA Deficiency: Epidemiology, Pathogenesis, Clinical Phenotype, Diagnosis, Prognosis and Management [0.03%]
选择性IgA缺乏症的流行病学、发病机制、临床表现、诊断、预后和处理方法
R Yazdani,G Azizi,H Abolhassani et al.
R Yazdani et al.
Selective immunoglobulin A deficiency (SIgAD) is the most common primary antibody deficiency. Although more patients with SIgAD are asymptomatic, selected patients suffer from different clinical complications such as pulmonary infections, a...
Humoral and Cellular Responses to a Single Dose of Fendrix in Renal Transplant Recipients with Non-response to Previous Hepatitis B Vaccination [0.03%]
肾移植受者单剂量风亭和富免疫球蛋白的体液及细胞反应：之前对乙型肝炎疫苗无应答者
M Lindemann,M Zaslavskaya,M Fiedler et al.
M Lindemann et al.
Approximately 70% of kidney transplant recipients are non-responders to conventional hepatitis B virus (HBV) vaccines. We examined whether Fendrix™, an HBV vaccine containing 3-O-desacyl-4'-monophosphoryl lipid A (MPL) as adjuvant, could i...
The Influenza A Virus Non-structural Protein NS1 Upregulates The Expression of Collagen Triple Helix Repeat Containing 1 Protein [0.03%]
流感A病毒非结构蛋白NS1上调三联 helix repeat-containing protein 1的表达
C Zhu,G Peng,W Yi et al.
C Zhu et al.
Influenza A virus (IAV) infection induces a strong immune response and regulates the expression of many host proteins. The collagen triple helix repeat containing 1 (CTHRC1) protein is a secreted protein that exhibits increased expression d...
Immune Response of Healthy Adults to the Ingested Probiotic Lactobacillus casei Shirota [0.03%]
干酪乳杆菌代田株的健康成人免疫反应研究
L S Harbige,E Pinto,J Allgrove et al.
L S Harbige et al.
Daily ingestion of a probiotic drink containing Lactobacillus casei Shirota (LcS; 1.3 × 1010 live cells) by healthy adults for (1) 4-week LcS, (2) 6-week discontinuation of LcS and (3) a final 4 weeks of LcS was investigated. There was a s...