Expression of Toll-Like Receptors in Peripheral Blood Mononuclear Cells of Patients with Primary Sjögren's Syndrome [0.03%]
原发性舍格伦综合征患者外周血单个核细胞TLR表达分布及其与临床症状的关系
M Karlsen,K Jakobsen,R Jonsson et al.
M Karlsen et al.
Toll-like receptors (TLRs) are pattern recognition receptors important for the detection of pathogen-associated molecular patterns. They are localized on cellular membranes, on either the cell surface or the endosomes. Primary Sjögren's sy...
Analysis of miR-146a and miR-142-3p as Potential Markers of Freshly Isolated or In Vitro-Expanded Human Treg cells [0.03%]
miR-146a和miR-142-3p作为新鲜分离或体外扩增的人Treg细胞潜在标志物的分析研究
K Holmstrøm,A E Pedersen,M Gad
K Holmstrøm
Regulatory CD4+ T cells (Tregs) are pivotal for prevention of autoimmunity. The use of Tregs is therefore of increasing interest in in vitro drug screening assays as well as for a cytotherapy per se against autoimmune disorders. For both pu...
The Inflammation Induced by Lipopolysaccharide can be Mitigated by Short-chain Fatty Acid, Butyrate, through Upregulation of IL-10 in Septic Shock [0.03%]
短链脂肪酸丁酸通过上调IL-10缓解内毒素诱导的脓毒性休克炎症反应
F Wang,J Liu,T Weng et al.
F Wang et al.
Short-chain fatty acids (SCFAs) with the anti-inflammatory capacity are produced by intestinal bacteria; however, their effect on the acute systematical inflammation remains unclear. This study aimed to investigate the effects of SCFAs, ace...
IL-12B Gene Polymorphisms and IL-12 p70 Serum Levels Among Patients with Rheumatoid Arthritis [0.03%]
类风湿关节炎患者IL-12B基因多态性及其与血清中IL-12p70水平的关系研究
A Paradowska-Gorycka,A Sowinska,B Stypińska et al.
A Paradowska-Gorycka et al.
Rheumatoid arthritis (RA) is one of the autoimmune diseases, where different polymorphisms in cytokine genes play a pathogenic role. IL-12 is now recognized as a critical cytokine in terms of regulating the balance between Th1 and Th2 cells...
CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein [0.03%]
TCAP的T细胞特异性衔接蛋白的潜在作用靶点是CD6和活化T细胞的衔接分子
C D Hem,M Ekornhol,S Granum et al.
C D Hem et al.
The T cell-specific adaptor protein (TSAd) contains several protein interaction domains, and is merging as a modulator of T cell activation. Several interaction partners for the TSAd proline-rich region and phosphotyrosines have been identi...
Immunomodulatory and Immunosuppressive Roles of 1α,25(OH)2D3 in Autoimmune Diseases [0.03%]
1α,25(OH)2D3在自身免疫性疾病中的免疫调节和免疫抑制作用
H Alhassan Mohammed,A A Saboor-Yaraghi,A Mirshafiey et al.
H Alhassan Mohammed et al.
Autoimmune diseases are pathological conditions characterized by abnormal responses, accompanied by autoantibodies to self-molecules. The role of vitamin D in autoimmune diseases has increased significantly in the recent past from its funct...
Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation [0.03%]
免疫耐受性。关于免疫调节基本概念研讨会报告的第一部分
C C Anderson,P Bretscher,A Corthay et al.
C C Anderson et al.
This report, the first of two, arose from a one-week workshop directed at discussing concepts of immune regulation, and focuses on immunological tolerance. We first outline the major ideas we thought sufficiently plausible to provide a cont...
Serum sPD-L1, Upregulated in Sepsis, May Reflect Disease Severity and Clinical Outcomes in Septic Patients [0.03%]
血清sPD-L1在脓毒症中上调，可能反映脓毒症患者的疾病严重程度和临床结局
M Liu,X Zhang,H Chen et al.
M Liu et al.
We aimed to find the correlation between serum sPD-L1 (soluble programmed cell death L-1 ligand) and sepsis. Totally 91 consecutive patients with sepsis were performed in a 15-bed medical intensive care unit (ICU) of the second affiliated h...
Observational Study
Scandinavian journal of immunology. 2017 Jan;85(1):66-72. DOI:10.1111/sji.12509 2017
Thyrotropin Alters T Cell Development in the Thymus in Subclinical Hypothyroidism Mouse Model [0.03%]
亚临床甲状腺功能减退小鼠模型中促甲状腺激素改变胸腺T细胞发育
K Wu,M Zhao,C Ma et al.
K Wu et al.
Subclinical hypothyroidism (SCH) is highly prevalent in the general population and is associated with potential deleterious effects. Although developing T cells express thyroid-stimulating hormone receptor (TSH-R), the changes of T cell dev...
The Clinical Relevance of Antifibrillarin (anti-U3-RNP) Autoantibodies in Systemic Sclerosis [0.03%]
抗纤维原自身抗体（抗U3-RNP）在系统性硬化症中的临床意义
F Tall,M Dechomet,S Riviere et al.
F Tall et al.
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease associated with several antinuclear autoantibodies useful to diagnosis and prognosis. The aim of the present multicentric study was to determine the clinical relevance of antifi...
Observational Study
Scandinavian journal of immunology. 2017 Jan;85(1):73-79. DOI:10.1111/sji.12510 2017