Breadth of T Cell Responses After Immunization with Adenovirus Vectors Encoding Ancestral Antigens or Polyvalent Papillomavirus Antigens [0.03%]
腺病毒载体编码乳头瘤病毒泛型抗原或谱系特异性抗原诱导的T细胞免疫反应宽度
E Ragonnaud,A G Pedersen,P J Holst
E Ragonnaud
Oncogenic human papillomaviruses (HPVs) are in most cases eliminated by intervention of T cells. As many other pathogens, these oncogenic HPVs belong to an ancient and diverse virus family. Therefore, we found it relevant to investigate the...
Immune Regulation by T Regulatory Cells in Hepatitis B Virus-Related Inflammation and Cancer [0.03%]
HBV相关炎症和肿瘤发生过程中T调节性细胞的免疫调控功能研究
N Trehanpati,A K Vyas
N Trehanpati
Hepatocellular carcinoma (HCC) is the leading cause of cancer death, and hepatitis B virus (HBV) infection is one of the commonest causes in Asian countries. India has the second largest pool after China for hepatitis B-infected subjects. H...
Investigation of Genetic Defects in Severe Combined Immunodeficiency Patients from Turkey by Targeted Sequencing [0.03%]
土耳其严重联合免疫缺陷病患者的靶向测序遗传缺陷研究
B Erman,I Bilic,T Hirschmugl et al.
B Erman et al.
Primary immunodeficiencies (PIDs) represent a large group of disorders with an increased susceptibility to infections. Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiencies (PIDs) with marked T-cell l...
R Jonsson
R Jonsson
K A Brokstad
K A Brokstad
F L Jahnsen,F-E Johansen,G Haraldsen
F L Jahnsen
Impaired Akt Phosphorylation in Monocytes of Patients with Rheumatoid Arthritis [0.03%]
类风湿关节炎患者单核细胞Akt磷酸化受损
K Kuuliala,A Kuuliala,M Hämäläinen et al.
K Kuuliala et al.
It has been proposed that the Akt kinase pathway provides a regulatory mechanism to limit the inflammatory response. We examined the activation of Akt upon lipopolysaccharide (LPS) challenge in monocytes of patients with rheumatoid arthriti...
Association Between TNF-α Promoter -308 A/G Polymorphism and Systemic Lupus Erythematosus Susceptibility: A Case-Control Study and Meta-Analysis [0.03%]
肿瘤坏死因子-α启动子-308A/G多态性与系统性红斑狼疮易感性的关联：病例对照研究和荟萃分析
Z-C Yang,F Xu,M Tang et al.
Z-C Yang et al.
The tumour necrosis factor-α (TNF-α) promoter -308 A/G polymorphism plays an important role in the aetiology of systemic lupus erythematosus (SLE). Several studies have estimated the association between TNF-α -308 A/G and SLE risk. Howev...
M2000 (β-D-Mannuronic Acid) as a Novel Antagonist for Blocking the TLR2 and TLR4 Downstream Signalling Pathway [0.03%]
M2000（D-岩藻糖）作为TLR2和TLR4下游信号转导通路的阻断剂的新拮抗剂
S Aletaha,L Haddad,M Roozbehkia et al.
S Aletaha et al.
To date, selective blockade of Toll-like receptor (TLR) signalling has been developed as a new approach for treatment for many inflammatory diseases. As β-D-mannuronic acid (M2000) has been known as an anti-inflammatory molecule in several...
In vitro Monocyte IL-6 Secretion Levels Following Stimulation with Autologous Spheroids Derived from Tumour or Benign Mucosa Predict Long-term Survival in Head and Neck Squamous Cell Carcinoma Patients [0.03%]
体外单核细胞自分泌型IL-6水平预测头颈部鳞状细胞癌患者长期生存率
H J Aarstad,H H Aarstad,O K Vintermyr et al.
H J Aarstad et al.
MCP-1/IL-6 in vitro monocyte secretion upon coculture with autologous fragment spheroids was studied in relation to patient 5- and 10-year overall survival rates in head and neck squamous cell carcinoma (HNSCC) patients (n = 65) diagnosed b...