A Non-pathogenic Recombinant Leishmania Expressing Lipophosphoglycan 3 Against Experimental Infection with Leishmania infantum [0.03%]
一种非致病性レシチンアミド水解酶基因缺失型李什曼虫株的构建及其对弓形虫毒力的影响
L Pirdel,S Farajnia
L Pirdel
Visceral leishmaniasis (VL) is caused by Leishmania infantum in the Mediterranean basin and affects primarily children and immunosuppressed individuals. Various strategies of vaccination have so far been examined by either protein or DNA wi...
Subunit Vaccines Consisting of Antigens from Dormant and Replicating Bacteria Show Promising Therapeutic Effect against Mycobacterium Bovis BCG Latent Infection [0.03%]
由休眠和增殖结核分枝杆菌组成的亚单位疫苗对潜伏性BCG感染具有治疗作用
F Li,H Kang,J Li et al.
F Li et al.
To screen effective antigens as therapeutic subunit vaccines against Mycobacterium latent infection, we did bioinformatics analysis and literature review to identify effective antigens and evaluated the immunogenicity of five antigens highl...
Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in CD8+ T Cytotoxic Lymphocytes and CD19+ B Lymphocytes in Rheumatoid Arthritis Responding to TNF-α Inhibition [0.03%]
肿瘤坏死因子拮抗剂治疗响应的类风湿关节炎患者CD8+T细胞毒性淋巴细胞和CD19+B淋巴细胞黑素皮质激素受体2、3及4基因表达下调
M Andersen,I Nagaev,M K Meyer et al.
M Andersen et al.
Melanocortin signalling in leucocyte subsets elicits anti-inflammatory and immune tolerance inducing effects in animal experimental inflammation. In man, however, the effects of melanocortin signalling in inflammatory conditions have scarce...
TLR-Stimulated Eosinophils Mediate Recruitment and Activation of NK Cells In Vivo [0.03%]
TLR激活的嗜酸性粒细胞介导NK细胞的体内募集和活化
S M O&#x;Flaherty,K Sutummaporn,W L Häggtoft et al.
S M O&#x;Flaherty et al.
Eosinophils like many myeloid innate immune cells can provide cytokines and chemokines for the activation of other immune cells upon TLR stimulation. When TLR-stimulated eosinophils were inoculated i.p. into wild-type mice, and NK cells wer...
A K Vyas,A Jindal,S Hissar et al.
A K Vyas et al.
Chronic hepatitis B virus (HBV) infection affects millions of people worldwide and about half a million people die every year. India represents the second largest pool of chronic HBV infections with an estimated 40 million chronically infec...
Dendritic Cells from Rheumatoid Arthritis Patient Peripheral Blood Induce Th17 Cell Differentiation via miR-363/Integrin αv/TGF-β Axis [0.03%]
miR-363/整合素αv/转化生长因子β轴调控树突状细胞促进类风湿关节炎患者外周血记忆T细胞向Th17细胞分化
F Pan,H Xiang,J Yan et al.
F Pan et al.
Dendritic cells (DCs) are critical regulators of immune responses. This study was to observe the effect of DCs from peripheral blood on the differentiation of Th17 in patients with rheumatoid arthritis (RA). Peripheral blood samples were co...
Identification and Characterization of a Nationwide Danish Adult Common Variable Immunodeficiency Cohort [0.03%]
丹麦全国成人常见变量免疫缺陷队列的识别和特征分析
L Westh,T H Mogensen,L S Dalgaard et al.
L Westh et al.
In this study, we identified all adults living in Denmark diagnosed with common variable immunodeficiency (CVID) and characterized them according to clinical presentation and EUROclass classification. Using a retrospective, cross-sectional ...
TCF1 deficiency ameliorates autoimmune lymphoproliferative syndrome (ALPS)-like phenotypes of lpr/lpr mice [0.03%]
TCF1缺陷可改善lpr/lpr小鼠的自身免疫性淋巴细胞增生综合征(ALLS)样表型
X Xu,B Yu,W Cai et al.
X Xu et al.
Autoimmune lymphoproliferative syndrome (ALPS) is an incurable disease, which is characterized by non-malignant autoimmune lymphoproliferation. TCF1 is a key effector in the canonical Wnt/β-catenin pathway, regulating the development, acti...
Immunoregulation of Inflammatory and Inhibitory Cytokines by Vitamin D3 in Patients with Inflammatory Bowel Diseases [0.03%]
维生素D3调节炎症性肠病患者炎性和抑制性细胞因子的免疫作用
H Alhassan Mohammed,A Mirshafiey,H Vahedi et al.
H Alhassan Mohammed et al.
Inflammatory bowel disease (IBD) is a group of idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract, caused by an aberrant and exaggerated immunological response in the gut. Supplementation of vitamin D3 i...
PTEN/PI3k/AKT Regulates Macrophage Polarization in Emphysematous mice [0.03%]
PTEN/PI3k/AKT调节肺气肿小鼠巨噬细胞极化
J Lu,L Xie,C Liu et al.
J Lu et al.
Macrophages play an important role in the pathogenesis of COPD. Macrophage polarization towards the M2 phenotype has been observed in the lung tissues of COPD patients and cigarette smokers. The molecular basis of this process remains uncle...