Increased Expression of Programmed Cell Death-1 in Regulatory T Cells of Patients with Severe Sepsis and Septic Shock: An Observational Clinical Study [0.03%]
严重脓毒症和中毒性休克患者调节性T细胞程序性死亡配体-1表达增加：一项临床观察研究
Q Liu,L An,Z Qi et al.
Q Liu et al.
While regulatory T cells (Tregs) constitutively express programmed cell death-1 (PD-1), the role of PD-1 expression in Tregs of patients with sepsis remains unclear. Thus, we determined PD-1 expression in Tregs from the peripheral blood of ...
Observational Study
Scandinavian journal of immunology. 2017 Nov;86(5):408-417. DOI:10.1111/sji.12612 2017
Mesenchymal Stem Cells Overexpressing Interleukin-35 Propagate Immunosuppressive Effects in Mice [0.03%]
过表达白细胞介素-35的间充质干细胞能增强免疫抑制作用：小鼠模型研究
H Guo,N Zhao,H Gao et al.
H Guo et al.
To explore generation of interleukin (IL)-35-expressing mouse adipocyte-derived mesenchymal stem cells (Ad-MSCs) using lentiviral vector and their potential immunosuppressive effects in mice. Ad-MSCs were isolated and cultured in vitro and ...
Systemic Treatment with a miR-146a Mimic Suppresses Endotoxin Sensitivity and Partially Protects Mice from the Progression of Acute Graft-versus-Host Disease [0.03%]
系统性给予miR-146a模拟物可抑制内毒素敏感性并部分保护小鼠免于急性移植物抗宿主病的进展
J G Gartner,M M Durston,S A Booth et al.
J G Gartner et al.
Acute GVHD (aGVHD) is driven by interactions between the allogenic T cell response, inflammation, tissue injury and microbial products that enter the circulation when protective barriers such as the intestinal epithelium become compromised....
The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets [0.03%]
巨细胞病毒感染对人外周血各免疫亚群HLA-G及其配体KIR2DL4表达的影响
Z Albayati,A Alyami,S Alomar et al.
Z Albayati et al.
HLA-G is a non-classical class I HLA antigen, normally expressed in high levels only on extravillous cytotrophoblast. It has immunosuppressive properties in pregnancy and has also been found to be upregulated on leucocytes in viral infectio...
In Response to 'The role of circulating T follicular helper cells and regulatory cells in non-small cell lung cancer patients' [0.03%]
关于“非小细胞肺癌患者循环滤泡辅助T细胞和调节性细胞的作用”的答复
A K Vyas,R Khosla,N Trehanpati
A K Vyas
A Comparison of Clinical and Immunologic Phenotypes in Familial and Sporadic Forms of Common Variable Immunodeficiency [0.03%]
常见变异型免疫缺陷症家族性和散发性病例的临床和免疫表型比较
A Valizadeh,R Yazdani,G Azizi et al.
A Valizadeh et al.
Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency disease, and its prevalence varies significantly among different population. Minority of CVID patients present a familial aggregation suggesti...
Comparative Study
Scandinavian journal of immunology. 2017 Oct;86(4):239-247. DOI:10.1111/sji.12593 2017
The Lymphocytes Stimulation Induced DNA Release, a Phenomenon Similar to NETosis [0.03%]
淋巴细胞刺激诱导的DNA释放与NETosis现象类似
Y C Rocha Arrieta,M Rojas,G Vasquez et al.
Y C Rocha Arrieta et al.
The release of DNA into the extracellular milieu by neutrophil during a process called NETosis has been postulated as an additional source of autoantigens; a process believed to be important in the pathogenesis of some autoimmune disease, s...
Stochastics of Cellular Differentiation Explained by Epigenetics: The Case of T-Cell Differentiation and Functional Plasticity [0.03%]
表观遗传学解释细胞分化中的随机性——T细胞分化的案例及功能的可塑性
J Bhat,J Helmuth,G Chitadze et al.
J Bhat et al.
Epigenetic marks including histone modifications and DNA methylation are associated with the regulation of gene expression and activity. In addition, an increasing number of non-coding RNAs with regulatory activity on gene expression have b...
Clonal Analysis of Regulatory T Cell Defect in Patients with Autoimmune Polyendocrine Syndrome Type 1 Suggests Intrathymic Impairment [0.03%]
克隆分析 autoimmune polyendocrine syndrome type 1 患者的调节性T细胞缺陷提示胸腺内Treg发育障碍
T-T Koivula,S M Laakso,H J Niemi et al.
T-T Koivula et al.
Mutations in the autoimmune regulator gene disrupt thymic T cell development and negative selection, leading to the recessively inherited polyendocrine autoimmune disease autoimmune polyendocrine syndrome type 1 (APS-1). The patients also h...
A Mekinian,T Mahevas,M Mohty et al.
A Mekinian et al.
Systemic sclerosis (SSc) is an autoimmune disease, characterized by fibrosis of the skin and other organs, vascular impairment and deficient immune responses. Mucosal-associated invariant T cells (MAIT) have been involved in various inflamm...