Beyond Energy Fuel: Ketone Bodies as Multifaceted Modulators of T Cell and Anti-Tumour Immunity [0.03%]
超越能量燃料：酮体作为T细胞和抗肿瘤免疫的多功能调节因子
Zhi Gu,Minghui Zhang,Sheng Xia
Zhi Gu
The metabolic programme of T cells is pivotal in determining their differentiation, development and immune function. T cells undergo distinct metabolic reprogramming at various stages. Effector T cells primarily utilise glycolysis to genera...
Balachandran Ravindran
Balachandran Ravindran
The current conundrum of inflammation is that exogenous pathogen-associated molecular patterns (PAMPs) from microbial sources or endogenous damage-associated molecular patterns (DAMPs) released during trauma/tissue injury generate host infl...
The Role of CD36 and Its Regulatory Mechanisms in Metabolic Dysregulation and Tumorigenesis [0.03%]
CD36及其调控机制在代谢紊乱和肿瘤发生中的作用
Chunyu Tong,Wenzhi Feng,Honghao Yu et al.
Chunyu Tong et al.
Cluster of differentiation 36 (CD36) is a multifunctional membrane protein receptor widely expressed on the surface of various immune and nonimmune cells in the body, and it belongs to the class B scavenger receptor family (SR-B2). The extr...
Lessons From COVID-19 on Inborn Errors of Immunity: A Five-Year Narrative Review [0.03%]
从COVID-19中获得的关于先天性免疫缺陷的启示：五年回顾式综述
Gamze Sonmez,Gizem Gunduz,Saliha Esenboga et al.
Gamze Sonmez et al.
COVID-19 research now provides a coherent picture of the virus's immunological impacts, highlighting immune-evasion mechanisms, the particular vulnerabilities of patients with inborn errors of immunity (IEI), and evolving therapeutics for s...
Age-Matched Reference Values for Circulating Natural Killer T (NKT)-Like Cells [0.03%]
年龄匹配的外周自然杀伤T（NKT）细胞样细胞参考值
Elena Trombetta,Manuela Liguori,Federico Simone Colombo et al.
Elena Trombetta et al.
Natural Killer T-like cells are T lymphocytes characterised by the expression of CD56 accompanied by perforin and granzyme B production, typical of cytotoxic cells and the innate immunity compartment. Imbalance in their distribution could o...
The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro-Inflammatory Macrophages [0.03%]
核受体Nurr1调节人促炎性巨噬细胞中PPARγ的表达和活性
Eduardo Santana-Cisneros,Miguel A Solís-Barbosa,Norma C Segovia-Gamboa et al.
Eduardo Santana-Cisneros et al.
Nurr1 is a member of the nuclear receptor family NR4A that modulates inflammation typically by inhibiting the NF-κB signalling pathway. In vitro, Nurr1 can interact with the peroxisome proliferator-activated receptor (PPAR)γ, as well as b...
Exploring Potential Mechanisms for Epilepsy After mRNA COVID-19 Vaccination: An Extremely Rare Side-Effect [0.03%]
探索mRNA新冠疫苗后癫痫的潜在机制：一种极为罕见的副作用
Ahmed Faisal Mutee,Abdulkareem Shareef,S Renuka Jyothi et al.
Ahmed Faisal Mutee et al.
The rapid rollout of mRNA-based COVID-19 vaccines, including Pfizer-BioNTech's BNT162b2 and Moderna's mRNA-1273, has been instrumental in curbing the pandemic, demonstrating high efficacy and safety in the general population. However, conce...
The Invisible Lens: Why Theoretical Models Are Essential for Interpreting Immune Phenomena [0.03%]
无形的镜头：理论模型诠释免疫现象不可或缺的原因
Masoud H Manjili
Masoud H Manjili
Immunology progresses not merely by accumulating data but by evolving the conceptual lenses through which those data are interpreted; yet for six decades the self-non-self/infectious-non-self (SNS/INS) paradigm-casting allogeneity as activa...
Cross-Sectional and Longitudinal Immunoprofiling of Oligoarticular Juvenile Idiopathic Arthritis Reveals Different Patterns in Synovial Fluid and Plasma [0.03%]
少关节型幼年特发性关节炎的横断面和纵向免疫分析显示滑膜液和血浆中的模式不同
Heshuang Qu,Manoj Neog,Karin Palmblad et al.
Heshuang Qu et al.
Oligoarticular juvenile idiopathic arthritis (oligoJIA) constitutes nearly 60% of all JIA cases. The immune mechanisms involved in the pathogenesis remain incompletely understood. Few proteomic studies have been performed using synovial flu...
Evaluation of Inhibitory Activity of Novel Monoclonal Antibodies Against Cat Allergen Fel d 7 and Their Application to Analyse Allergen Extracts [0.03%]
新型抗Fel d 7单克隆抗体的抑制活性评价及其在分析过敏原提取物中的应用
Vytautas Rudokas,Glorismer Pena-Amelunxen,Peter Briza et al.
Vytautas Rudokas et al.
Current characterisation of cat dander/hair extracts used for allergy diagnosis or allergen-specific immunotherapy is mainly standardised towards the major allergen Fel d 1, while other allergens such as the lipocalin Fel d 7 are insufficie...