Targeting NgR1/NogoA Signalling Enhances Natural Killer Cell Cytotoxicity and Alters Immune and Oncogenic Pathways in TNBC Cells [0.03%]
靶向NgR1/NogoA信号传导可增强自然杀伤细胞的细胞毒作用并改变三阴性乳腺癌细胞中的免疫和致癌途径
Tuğcan Korak,Merve Gulsen Bal Albayrak,Murat Kasap et al.
Tuğcan Korak et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options, and impairment of natural killer (NK) cell cytotoxicity within the tumour microenvironment remains a major challenge. The present study investig...
Immunological Dynamics of Helminth Infections: From Host Defence and Immune Evasion Mechanisms to Vaccine Strategies [0.03%]
寄生虫感染的免疫动力学：从宿主防御和免疫逃避机制到疫苗策略
Héctor Serrano-Coll
Héctor Serrano-Coll
Helminthiasis refers to infections caused by parasitic worms, which represent a significant global health burden, particularly in tropical and subtropical regions. The pathophysiology of helminth infections is highly complex, largely due to...
Role of CXCR3 and CXCR6 on Circulating T Cells in Patients With Parkinson's Disease [0.03%]
CXCR3和CXCR6在帕金森病患者循环T细胞中的作用
Yufeng Zhang,Zhuangzhuang Ren,Shuangshuang Jia et al.
Yufeng Zhang et al.
Immune dysregulation is involved in Parkinson's disease (PD), but the roles of C-X-C motif chemokine receptor 3 (CXCR3)/chemokine receptor 6 (CXCR6) on T cells and their correlation with peripheral inflammation remain unclear. This study in...
Remarkable Rituximab Response in a Chronic Granulomatous Disease Patient on the Verge of a Lung Transplant [0.03%]
慢性肉芽肿病肺移植边缘患者的美罗华疗效
Zehra Genc Ozbay,Deniz Ilgun Gurel,Ozge Ozturk Aktas et al.
Zehra Genc Ozbay et al.
Ravichandran Sanjai,Kunka Mohanram Ramkumar
Ravichandran Sanjai
Diabetes mellitus (DM) is a chronic metabolic disorder characterised by persistent hyperglycemia, systemic metabolic dysfunction and insulin resistance (IR). Recent progress in the interplay between the immune system and metabolism highligh...
Andreas Lundqvist,Arnika K Wagner,Benedict J Chambers et al.
Andreas Lundqvist et al.
The discovery of natural killer (NK) cells stands among the fundamental milestones in modern immunology. To mark the 50-year anniversary of the first publications on NK cells in 1975, a symposium was held at Karolinska Institutet in Stockho...
CD71+ Red Blood Cells Mediate Increased Erythrophagocytosis and Reduce Monocyte Number in a Monocyte Suspension Assay [0.03%]
CD71+红细胞介导红细胞吞噬增加并减少单核细胞悬液测定中的单核细胞数量
Wenhui Li,Jason P Acker
Wenhui Li
Adverse reactions from donor-recipient sex-mismatched transfusions have been reported in the field of transfusion medicine. Immature CD71+ red blood cells (CD71+ RBCs) may influence these reactions through an immunomodulatory mechanism pote...
Augmenting the Jeffery Modell Criteria for Optimising Screening for Inborn Errors of Immunity [0.03%]
补充杰弗里·摩德尔标准以优化先天性免疫缺陷的筛查
Reetika Malik Yadav,Lavina Temkar,Umair Ahmed Bargir et al.
Reetika Malik Yadav et al.
Jeffrey Modell warning signs have been used to guide screening for inborn errors of immunity (IEIs) for over three decades now, but may lack sensitivity for noninfectious presentations. Our study explored JMF signs along with additional sig...
Similar Individual Serum Levels of MCP-1, TNF-α, and IL-6 From Periodontitis Patients Before and 1 Year After Treatment [0.03%]
牙周病患者治疗前后个体血清MCP-1、TNF-α和IL-6水平相近
Teun J de Vries,Sergio Bizzarro,Irene Di Ceglie et al.
Teun J de Vries et al.
Treatment of periodontitis may lower the inflammation status as measured in sera from patients. To investigate this in a biological assay, we co-cultured periodontal ligament fibroblasts (PDLFs) from a healthy donor and peripheral blood mon...