F-Box and WD repeat domain containing 7 induces infectious osteomyelitis by regulating MYB stability and ubiquitination [0.03%]
F-盒和WD重复结构域含7诱导感染性骨髓炎通过调节MYB稳定性和泛素化
Yongbo Wan,Gehan Jiang,Haojie Shan et al.
Yongbo Wan et al.
Osteomyelitis is a bone inflammation initiated by invading pathogens. Macrophages and inflammation play essential roles in osteomyelitis. F-Box and WD repeat domain containing 7 (Fbxw7) is a tumour suppressor and E3 ubiquitin ligase. In the...
Adropin regulates macrophage phenotype via PPARγ signalling: A preliminary study of adropin and Crohn's disease [0.03%]
ADROPIN通过PPARγ信号通路调节巨噬细胞表型：ADROPIN与克罗恩病初步研究
Lingli Zeng,Jintong Chen,Hongchai Xie et al.
Lingli Zeng et al.
Macrophage polarization is increasingly recognized as a vital pathogenetic factor in Crohn's disease (CD). Adropin is a secreted protein implicated in energy homeostasis, chiefly linked to glucose and lipid metabolism. However, the signific...
Sevgi Bilgic-Eltan,Razin Amirov,Royale Babayeva et al.
Sevgi Bilgic-Eltan et al.
Infants with congenital heart disease (CHD) often undergo thymectomy during corrective cardiac surgery (CCS). The long-term immunological effects remain controversial, with concerns regarding increased susceptibility to infections, allergie...
Immunomodulatory effect of mesenchymal stem cells-derived extracellular vesicles to modulate the regulatory T cells and Th1/Th2 imbalance in peripheral blood mononuclear cells of patients with allergic rhinitis [0.03%]
外泌体调节过敏性鼻炎患者外周血单个核细胞来源的间充质干细胞免疫调节作用及Treg和Th1/Th2失衡效应
Zhao Wang,Khawar Ali Shahzad,Xuran Li et al.
Zhao Wang et al.
Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have shown promising immunomodulatory capabilities for a variety of clinical conditions. However, the potential regulatory mechanisms of MSC-EVs in allergic rhinitis (AR) remain...
Peter Bergman
Peter Bergman
Probiotics as adjuvants to mitigate adverse reactions and enhance effectiveness in Food Allergy Immunotherapy [0.03%]
益生菌作为辅剂缓解食物过敏免疫治疗不良反应和增强疗效的研究进展
Ingrid Lamminpää,Elena Niccolai,Amedeo Amedei
Ingrid Lamminpää
In the past decades, food allergies became increasingly dominant since early childhood, leading to a lower quality of life and to increasing costs addressed by the health care system. Beside standard avoidance of specific allergens and drug...
Dysregulation of T cell response in the pathogenesis of inflammatory bowel disease [0.03%]
炎症性肠病发病机制中T细胞反应的失调
Rucha Chandwaskar,Rajdeep Dalal,Saurabh Gupta et al.
Rucha Chandwaskar et al.
Inflammatory bowel disease (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are gut inflammatory diseases that were earlier prevalent in the Western Hemisphere but now are on the rise in the East, with India standing se...
Whole exome sequencing in patients with childhood-onset systemic lupus erythematosus: Results from a Croatian national study [0.03%]
儿童期发病系统性红斑狼疮患者外显子组测序的成果——来自克罗地亚全国性的研究
Mario Sestan,Todor Arsov,Nastasia Kifer et al.
Mario Sestan et al.
The purpose of this study was to identify new and low-frequency gene variants using whole exome sequencing (WES) in patients with childhood-onset systemic lupus erythematosus (cSLE), that may be involved in the pathogenesis of SLE. We perfo...
Impact of gluten intake on clinical outcomes in patients with chronic inflammatory diseases initiating biologics: Secondary analysis of the prospective multicentre BELIEVE cohort study [0.03%]
gliadin摄入对开始使用生物制剂的慢性炎症性疾病患者的临床结局的影响：来自前瞻性多中心BELIEVE队列研究的事后分析
Laura Gregersen,Pernille Dyhre Jessen,Helene Wiencke Lund et al.
Laura Gregersen et al.
Chronic inflammatory diseases (CIDs) pose a growing healthcare challenge, with a substantial proportion of patients showing inadequate response to biological treatment. There is renewed interest in dietary changes to optimize treatment regi...
Multicenter Study
Scandinavian journal of immunology. 2024 Dec;100(6):e13409. DOI:10.1111/sji.13409 2024
Tetraspanin32 (TSPAN32) is downregulated in rheumatoid arthritis: Evidence from animal models and patients [0.03%]
四次跨膜蛋白32(TSPAN32)在类风湿关节炎中下调：来自动物模型和患者的证据
Katia Mangano,Jose&#x; Francisco Munoz-Valle,Claudia Azucena Palafox-Sánchez et al.
Katia Mangano et al.
This study aimed to investigate the role of TSPAN32, a member of the tetraspanin family, in rheumatoid arthritis (RA). The objective was to assess the expression levels of TSPAN32 in experimental RA models and in RA patient immune cells, ex...