Multispectral autofluorescence for label free classification of immune cell type and activation/polarization status [0.03%]
无标记分类免疫细胞类型的多光谱自体荧光及其活化/极化状态
Abbas Habibalahi,Ayad G Anwer,Aline Knab et al.
Abbas Habibalahi et al.
Evaluating immune status is a challenging and time-consuming process that involves analysing various biomarkers through numerous assays. The sensitive label-free technique of multispectral imaging of cell autofluorescence involves directly ...
Peripheral monocyte subsets are altered during gestation in oocyte donation pregnancy complicated with pre-eclampsia [0.03%]
卵胞捐赠妊娠并发子痫前期时外周单核细胞亚群在妊娠期间发生变化
Xuezi Tian,Jia Li,Kim van Bentem et al.
Xuezi Tian et al.
Oocyte donation (OD) pregnancies show a higher fetal-maternal incompatibility and a higher risk of developing pre-eclampsia (PE) than autologous pregnancies. As maternal monocytes play a role in the tolerization of the allogeneic fetus, the...
Combined inhibition of membrane receptors as therapeutic targets in rheumatoid arthritis [0.03%]
膜受体联合抑制在类风湿性关节炎治疗中的作用
Guilherme Pegas Teixeira,Jonathas Albertino de Souza Oliveira,Leandro Rocha et al.
Guilherme Pegas Teixeira et al.
The COVID-19 vaccine ChAdOx1 is opsonized by anti-vector antibodies that activate complement and promote viral vector phagocytosis [0.03%]
新冠疫苗ChAdOx1被抗载体抗体包被，激活补体并促进病毒载体吞噬作用
Eija Nissilä,Leo Starck,Elias Aho et al.
Eija Nissilä et al.
The ChAdOx1 nCoV-19 vaccine has been in large-scale use during the COVID-19 pandemic. Limited efficacy compared to mRNA vaccines and certain potential side effects raise the question of whether anti-adenoviral vector antibodies influence im...
The impact of cytokines and tumour-conditioned medium on the properties of murine in vitro generated myeloid-derived suppressor cells [0.03%]
细胞因子和肿瘤细胞培养上清对小鼠体外诱导的髓源性抑制细胞特性的影响
Mona Awad,Aleksandra Sen&#x;kova,Marina Zenkova et al.
Mona Awad et al.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of immature myeloid cells playing a critical role in immune suppression. In vitro-generated MDSCs are a convenient tool to study the properties of tumour-associated MDSCs. H...
Vitamin D3-VDR and vitamin A-RAR affect IL-13 and IFNγ secretion from human CD4+ T cells directly and indirectly via competition for their shared co-receptor RXR [0.03%]
维生素D3-VDR和维生素A-RAR通过共同配体RXR受体的竞争直接或间接影响人类CD4+T细胞分泌IL-13和IFNγ的功能
Tiana Stanisic,Emma Uttrup Ewing,Alma Lindell et al.
Tiana Stanisic et al.
The effects of vitamin D and vitamin A in immune cells are mediated through the vitamin D receptor (VDR) and retinoic acid receptor (RAR), respectively. These receptors share the retinoid X receptor (RXR) co-factor for transcriptional regul...
Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease [0.03%]
降钙素基因相关肽及其受体促进干眼病中GM-CSF+ Th细胞的致病性
Hua Rong,Hai Yang,Qingqing Liu et al.
Hua Rong et al.
Dry eye disease (DED) is an inflammatory disorder in which CD4+ T cells play a significant role in its pathogenesis. A CD4+ T cell subset termed granulocyte-macrophage colony-stimulating factor-producing T helper (ThGM) cells would contribu...
Haematopoietic stem cell transplantation in children with inborn errors of immunity: A single centre experience [0.03%]
儿童先天性免疫缺陷的造血干细胞移植：单中心经验
Özlem Arman Bilir,Betül Karaatmaca,İkbal Ok Bozkaya et al.
Özlem Arman Bilir et al.
This study retrospectively analyzed the outcomes of 61 pediatric patients with inborn errors of immunity (IEI) who underwent hematopoietic stem cell transplantation (HSCT) between 2011 and 2023. Patients were categorized into primary immuno...
CBL/Cbl-b mediates Fas degradation to reduce neuronal damage in experimental autoimmune encephalomyelitis [0.03%]
CBL/Cbl-b介导Fas降解以减少实验性自身免疫性脑脊髓炎中的神经元损伤
Dongsheng Guan,Yingxia Li,Binyan Chen et al.
Dongsheng Guan et al.
Fas has been shown to positively regulate the differentiation of T helper 17 (Th17) cells in mouse models of experimental autoimmune encephalomyelitis (EAE). Fas protein expression is regulated by ubiquitination but has not been further stu...