Inhibition of Interferon Regulatory Factor 4 Suppresses Th1 and Th17 Cell Differentiation and Ameliorates Experimental Autoimmune Encephalomyelitis [0.03%]
干扰素调节因子4的抑制作用可减弱Th1和Th17细胞分化并改善自身免疫性脑脊髓炎
C Yang,D He,C Yin et al.
C Yang et al.
Multiple sclerosis (MS) is an autoimmune disease that is characterized by recurrent episodes of T-cell-mediated immune attack on central nervous system (CNS) myelin, leading to axon damage and progressive disability. Interferon regulatory f...
Effect of Perfusion Fluids on Recovery of Inflammatory Mediators in Microdialysis [0.03%]
灌注液对微量渗析介质中炎症介导因子恢复的影响研究
F Khan,A Pharo,J K Lindstad et al.
F Khan et al.
Microdialysis is an excellent tool to assess tissue inflammation in patients, but in vitro systems to evaluate recovery of inflammatory mediators have not been standardized. We aimed to develop a reference plasma preparation and evaluate di...
CD19-Chimeric Antigen Receptor T Cells for Treatment of Chronic Lymphocytic Leukaemia and Acute Lymphoblastic Leukaemia [0.03%]
CD19嵌合抗原受体T细胞治疗慢性淋巴细胞性白血病和急性淋巴细胞白血病
C L Lorentzen,P T Straten
C L Lorentzen
Adoptive cell therapy (ACT) for cancer represents a promising new treatment modality. ACT based on the administration of cytotoxic T cells genetically engineered to express a chimeric antigen receptor (CAR) recognizing CD19 expressed by B c...
Systemic Lupus Erythematosus--A Disease with A Dysregulated Type I Interferon System [0.03%]
系统性红斑狼疮是一种I型干扰素系统失调性疾病
N Hagberg,L Rönnblom
N Hagberg
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease characterized by the loss of tolerance to nuclear antigens, immune complex formation and inflammation in multiple organs. The disease is very heterogeneous, and mos...
Y M Mosaad
Y M Mosaad
Most of the genes in the major histocompatibility complex (MHC) region express high polymorphism that is fundamental for their function. The most important function of human leukocyte antigen (HLA) molecule is in the induction, regulation o...
Effect of Cardiac Resynchronization Therapy on Inflammation in Congestive Heart Failure: A Review [0.03%]
心脏再同步化治疗对充血性心力衰竭患者炎症影响的述评
K T Lappegård,H Bjørnstad,T E Mollnes et al.
K T Lappegård et al.
Congestive heart failure is associated with increased levels of several inflammatory mediators, and animal studies have shown that infusion of a number of cytokines can induce heart failure. However, several drugs with proven efficacy in he...
A Fogdell-Hahn
A Fogdell-Hahn
Chronic inflammatory diseases are now treated with a range of different biopharmaceuticals, often requiring lifelong parenteral administrations. This exposure to drugs is unnatural and can trigger the immune system and result in the formati...
Administration of DNA Encoding the Interleukin-27 Gene Augments Antitumour Responses through Non-adaptive Immunity [0.03%]
携带IL-27基因DNA的给药通过非适应性免疫增强抗肿瘤反应
Q Li,A Sato,O Shimozato et al.
Q Li et al.
DNA-mediated immunization of a tumour antigen is a possible immunotherapy for cancer, and interleukin (IL)-27 has diverse functions in adaptive immunity. In this study, we examined whether IL-27 DNA administration enhanced antitumour effect...
A Saralahti,M Rämet
A Saralahti
Streptococcal bacteria are a versatile group of gram-positive bacteria capable of infecting several host organisms, including humans and fish. Streptococcal species are common colonizers of the human respiratory and gastrointestinal tract, ...
Inhibition of Interferon Regulatory Factor 4 Attenuates Acute Liver Allograft Rejection in Mice [0.03%]
抑制干扰素调节因子4能够减弱小鼠急性肝移植排斥反应
W Zhao,Z Zhang,Q Zhao et al.
W Zhao et al.
Acute liver allograft rejection is a serious complication after liver transplantation. Interferon regulatory factor 4 (IRF4) is expressed predominantly in the immune system and plays an important role in its development and function. Howeve...