Oral Local Budesonide Treatment Ameliorates Immune Activation and Colonic Sensitivity in a Spontaneous Model for Disorders of Gut-Brain Interaction [0.03%]
口服布地奈德治疗改善了肠道内脏感觉异常模型小鼠免疫激活及结肠高敏感性
Alison Accarie,Pauline Huyghe,Mathieu Meleine et al.
Alison Accarie et al.
Background: Disorders of gut-brain interaction (DGBI), such as functional dyspepsia and irritable bowel syndrome, are characterized by immune activation and increased permeability in the gastrointestinal tract. However, t...
The Neuroepithelial Landscape of Enterochromaffin Cells Varies Across Gastrointestinal Location [0.03%]
胃肠分布的肠嗜铬细胞神经上皮景观不同
Lauren A Jones,Rosie A Coleman,Caitlin Allman et al.
Lauren A Jones et al.
Background and aims: Enteroendocrine cells (EECs) lining the gastrointestinal (GI) wall sense chemical and mechanical changes in the gut, secreting an array of hormones and neurotransmitters in response. Enterochromaffin ...
Altered Duodenal Mucosa-Associated Microbiota and Immune Profiles in Functional Dyspepsia: A Study of Host-Microbiome Homeostasis [0.03%]
功能性消化不良中改变的十二指肠黏膜相关微生物群和免疫特征：宿主-微生物稳态的研究
Emily C Hoedt,Grace L Burns,Seungha Kang et al.
Emily C Hoedt et al.
Background: Recent work suggests an altered duodenal mucosa-associated microbiota (d-MAM) in patients with functional dyspepsia (FD) when compared to controls. This may reflect alterations in host-microbiome homeostasis. ...
Dose-Dependent Effect of the Histamine 1 Receptor Antagonist Ebastine in Patients With Non-Constipated Irritable Bowel Syndrome [0.03%]
依巴斯汀治疗非便秘型肠易激综合征患者的剂量效应研究
Fedrica Pia,Lisse Decraecker,Danny De Looze et al.
Fedrica Pia et al.
Background: Current treatment options for irritable bowel syndrome (IBS) mainly focus on restoring abnormal stool patterns but are less effective in relieving abdominal pain. Recent studies have identified mast cells as k...
Clinical Trial
Neurogastroenterology and motility. 2026 Jan;38(1):e70242. DOI:10.1111/nmo.70242 2026
Can Esophageal Anatomy Help to Choose Between Functional Luminal Imaging Probe (FLIP) and Barium Esophagogram in Achalasia? [0.03%]
食管解剖结构能帮助选择功能性腔内影像探针还是钡餐食管造影用于治疗 achalasia 吗？
N Mattio,E Boissier,F Mion et al.
N Mattio et al.
Background: Functional luminal imaging probe (FLIP) and barium esophagogram (BE) are complementary to high-resolution manometry in achalasia. Anatomical changes and achalasia treatment could alter their interpretation. Ou...
Revisiting the Incidence of Tardive Dyskinesia With Oral Metoclopramide Use: A Real-World Epidemiology Study (2011-2020) [0.03%]
口服多潘立酮使用与迟发性运动障碍发生率关系的再评价：一项真实世界流行病学研究（2011年—2020年）
Richard W McCallum,Henry P Parkman,Linda A Nguyen et al.
Richard W McCallum et al.
Background: Gastroparesis is a debilitating disorder with limited treatment options, and metoclopramide remains the only FDA-approved pharmacologic therapy. Concerns about metoclopramide-induced tardive dyskinesia (TD) ar...
Psychological Symptoms and Adverse Childhood Experiences Negatively Impact Coexisting Obstructed Defecation and Fecal Incontinence Symptoms [0.03%]
心理症状和童年不良经历对同时存在的排便障碍和大便失禁症状产生负面影响
Elisa Karhu,Brooke Gurland,Meredith R Craven et al.
Elisa Karhu et al.
Introduction: Many patients with obstructed defecation report concurrent fecal incontinence. However, the impact of psychological factors on coexisting symptoms remains unclear. We aimed to investigate the association bet...
Exploring Clinical Similarities and Distinctions Between Gastroparesis and Functional Dyspepsia: A Propensity-Matched Cohort Study [0.03%]
胃轻瘫和功能性消化不良临床特征的相似性和差异性：一项倾向匹配队列研究
Sameer Rao,Vraj Shah,Rohan Karkra et al.
Sameer Rao et al.
Background and aims: Gastroparesis and functional dyspepsia often share overlapping upper gastrointestinal symptoms but may differ in symptom patterns, treatment, and health care utilization. We assessed their clinical si...
Transverse Rectal Diameter: Predictor of Severity in Children With Chronic Functional Constipation [0.03%]
横行直肠直径：儿童慢性功能性便秘严重程度的预测指标
F Proli,G Margiotta,G Stella et al.
F Proli et al.
Background: This study aims to evaluate transverse rectal diameter (TRD) as a predictor of clinical severity and response to conventional treatment in children with chronic functional constipation (CFC). ...