Role of the Multicopper Oxidase CueO in Copper Homeostasis Under Anaerobic Conditions in Enterobacteria [0.03%]
致病性肠道菌属厌氧条件下铜稳态中多铜氧化酶CueO的作用
Jérôme Becam,Maxence Dessertine,Alexandra Vergnes et al.
Jérôme Becam et al.
The periplasmic multicopper oxidase CueO plays a crucial role in copper detoxification in enterobacteria. CueO contains a catalytic site, the Cu-T1 center, and a methionine-rich (Met-rich) domain capable of binding copper. This enzyme oxidi...
Multifaceted Roles of chs Genes in Regulating Cell Growth, Mycelial Morphology, Monascus Pigments and Citrinin Biosynthesis in Monascus purpureus [0.03%]
红曲霉菌细胞生长、菌丝形态、色素和橘霉素生物合成中chs基因的多种作用机制研究
Chenyu Zhang,Xinyi Liu,Song Zhang et al.
Chenyu Zhang et al.
Chitin biosynthesis is intricately linked to the cellular growth and secondary metabolism of microorganisms. Our previous research has evaluated the role of the chs6 gene in modulating spore germination, mycelial morphology, and Monascus pi...
Impairment of Lipoylation Mediated by Bromooctanoate Targets Eukaryotic Amidotransferases [0.03%]
溴辛酸介导的辅酶A脂酰化损伤导致氨甲基转移酶功能障碍
Albertina Scattolini,Joaquín Costa,Tulio L Pianessi et al.
Albertina Scattolini et al.
Lipoylation is a post-translational modification in which lipoic acid is attached to specific apoproteins of enzyme complexes, like E2 subunits of dehydrogenases or GcvH of the glycine cleavage system. A defining feature of organisms with a...
Cyclic Di-AMP Affects Cell Membrane Integrity of Streptococcus pneumoniae [0.03%]
环式二鸟苷酸-2'-3'-胞苷酸通过影响肺炎链球菌细胞膜完整性抑制细菌生物被膜的形成
Tiffany M Zarrella,Jianle Gao,Nathan Forrest et al.
Tiffany M Zarrella et al.
Competence is an important bioprocess for Streptococcus pneumoniae. Previously, we demonstrated that the bacterial second messenger cyclic di-adenosine monophosphate (c-di-AMP) modulates pneumococcal competence. Surprisingly, cdaA*, a strai...
An HWE-Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response [0.03%]
一个HWE家族组氨酸激酶调节布鲁氏菌细胞包膜性质和宿主天然免疫应答
Xingru Chen,Emily Perez,Eleanor C Scheeres et al.
Xingru Chen et al.
The bacterial cell envelope is essential for viability and host interaction. In the intracellular pathogen Brucella ovis, the orphan HWE-family histidine kinase PhyK has been implicated in processes that influence cell envelope homeostasis,...
In Hyphomicrobium denitrificans Two Related Sulfane-Sulfur Responsive Transcriptional Repressors Regulate Thiosulfate Oxidation and Have a Deep Impact on Nitrate Respiration and Anaerobic Biosyntheses [0.03%]
两种相关的硫化硫响应性转录阻遏物调节反硝化螺菌中的硫化硫酸盐氧化并在一定程度上影响硝酸盐呼吸和厌氧生物合成
Jingjing Li,Nora E Schmitte,Kaya Törkel et al.
Jingjing Li et al.
Bacteria have evolved multiple strategies to sense and respond to the availability of inorganic reduced sulfur compounds such as thiosulfate. In Hyphomicrobium denitrificans, an obligately chemoorganoheterotrophic Alphaproteobacterium, the ...
Natalia de Miguel,María Carolina Touz,Manuela Blasco Pedreros et al.
Natalia de Miguel et al.
Infections caused by single-celled protozoan parasites affect countless individuals around the world, particularly in low- and middle-income countries. Despite the significant impact on global health, available therapeutic intervention stra...
The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB): A Large-Scale Guide to Genetic Conditional Essentiality [0.03%]
《结核分支杆菌转座子测序数据库（MtbTnDB）：遗传条件必需性的大规模指南》
Adrian Jinich,Anisha Zaveri,Michael A DeJesus et al.
Adrian Jinich et al.
Characterizing genetic essentiality across various conditions is fundamental for understanding gene function. Transposon sequencing (TnSeq) is a powerful technique to generate genome-wide essentiality profiles in bacteria and has been exten...
Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase [0.03%]
金黄色葡萄球菌COL：一个由于嘌呤核苷酸磷酸化酶突变导致生长缓慢和耐药的非典型MRSA模型菌株
Claire E Stevens,Ashley T Deventer,Paul R Johnston et al.
Claire E Stevens et al.
Methicillin-resistant Staphylococcus aureus (MRSA) has been a pathogen of global concern since its emergence in the 1960s. As one of the first MRSA strains isolated, COL has become a common model strain of S. aureus. Here we report that COL...