Mycobacterium tuberculosis requires glyoxylate shunt and reverse methylcitrate cycle for lactate and pyruvate metabolism [0.03%]
丙酮酸和乳酸代谢需要甘氨酸穿梭逆甲基柠檬酸循环
Agnese Serafini,Lendl Tan,Stuart Horswell et al.
Agnese Serafini et al.
Bacterial nutrition is an essential aspect of host-pathogen interaction. For the intracellular pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans, fatty acids derived from lipid droplets are considered ...
Functional studies of aegerolysin and MACPF-like proteins in Aspergillus niger [0.03%]
黑色曲霉中aegerolysin和MACPF样蛋白的功能研究
Maruša Novak,Urška Čepin,Vesna Hodnik et al.
Maruša Novak et al.
Proteins of the aegerolysin family have a high abundance in Fungi. Due to their specific binding to membrane lipids, and their membrane-permeabilization potential in concert with protein partner(s) belonging to a membrane-attack-complex/per...
A role for the Salmonella Type III Secretion System 1 in bacterial adaptation to the cytosol of epithelial cells [0.03%]
沙门氏菌第三类分泌系统1在细菌适应上皮细胞细胞质过程中的作用
Audrey Chong,Tregei Starr,Ciaran E Finn et al.
Audrey Chong et al.
Salmonella enterica serovar Typhimurium is a facultative intracellular pathogen that invades the intestinal epithelium. Following invasion of epithelial cells, Salmonella survives and replicates within two distinct intracellular niches. Whi...
Chaperone OsmY facilitates the biogenesis of a major family of autotransporters [0.03%]
伴侣蛋白OsmY通过辅助一类主要自转运蛋白的生成来促进其生物发生
Zhen Yan,Sunyia Hussain,Xu Wang et al.
Zhen Yan et al.
OsmY is a widely conserved but poorly understood 20 kDa periplasmic protein. Using a folding biosensor, we previously obtained evidence that OsmY has molecular chaperone activity. To discover natural OsmY substrates, we screened for protein...
Identification, characterization and benefits of an exclusion system in an integrative and conjugative element of Bacillus subtilis [0.03%]
芽孢杆菌整合和接合元件中一种排除系统的鉴定、表征及其益处
Monika Avello,Kathleen P Davis,Alan D Grossman
Monika Avello
Integrative and conjugative elements (ICEs) are mobile genetic elements that transfer from cell to cell by conjugation (like plasmids) and integrate into the chromosomes of bacterial hosts (like lysogenic phages or transposons). ICEs are pr...
Determinants of target prioritization and regulatory hierarchy for the bacterial small RNA SgrS [0.03%]
细菌小RNA SgrS的目标优先级和调控层级的决定因素
Maksym Bobrovskyy,Muhammad S Azam,Jane K Frandsen et al.
Maksym Bobrovskyy et al.
Small RNA (sRNA) regulators promote efficient responses to stress, but the mechanisms for prioritizing target mRNA regulation remain poorly understood. This study examines mechanisms underlying hierarchical regulation by the sRNA SgrS, foun...
Identification of the Toxoplasma gondii mitochondrial ribosome, and characterisation of a protein essential for mitochondrial translation [0.03%]
鉴定弓形虫线粒体核糖体并表征一种对线粒体翻译过程必不可少的蛋白
Alice Lacombe,Andrew E Maclean,Jana Ovciarikova et al.
Alice Lacombe et al.
Apicomplexan parasites cause diseases such as malaria and toxoplasmosis. The apicomplexan mitochondrion shows striking differences from common model organisms, including fundamental processes such as mitochondrial translation. Despite evide...
Transcriptional initiation of a small RNA, not R-loop stability, dictates the frequency of pilin antigenic variation in Neisseria gonorrhoeae [0.03%]
链原核生物中一个小RNA的转录起始，而不是R环稳定性，决定了该细菌衣皮蛋白变异频率
Lauren L Prister,Egon A Ozer,Laty A Cahoon et al.
Lauren L Prister et al.
Neisseria gonorrhoeae, the sole causative agent of gonorrhea, constitutively undergoes diversification of the Type IV pilus. Gene conversion occurs between one of the several donor silent copies located in distinct loci and the recipient pi...
Identification of the lipopolysaccharide O-antigen biosynthesis priming enzyme and the O-antigen ligase in Myxococcus xanthus: critical role of LPS O-antigen in motility and development [0.03%]
黏质细黄杆菌O-抗原生物合成起始酶和O-抗原连接酶的鉴定：LPS O-抗原在运动性和发育中的关键作用
María Pérez-Burgos,Inmaculada García-Romero,Jana Jung et al.
María Pérez-Burgos et al.
Myxococcus xanthus is a model bacterium to study social behavior. At the cellular level, the different social behaviors of M. xanthus involve extensive cell-cell contacts. Here, we used bioinformatics, genetics, heterologous expression and ...
Regulation of toxic shock syndrome toxin-1 by the accessory gene regulator in Staphylococcus aureus is mediated by the repressor of toxins [0.03%]
金黄色葡萄球菌中， accessory基因调节毒休克综合症毒素-1的作用是由毒素抑制剂介导的
Stephen W Tuffs,Christine A Herfst,Miren L Baroja et al.
Stephen W Tuffs et al.
Toxic shock syndrome toxin-1 (TSST-1) is a superantigen (SAg) produced by Staphylococcus aureus thought to be responsible for essentially all cases of menstrual-associated toxic shock syndrome (TSS). As a potent exotoxin, it is not surprisi...