The Flagellin-Specific Chaperone FliS of Borrelia burgdorferi Controls the Cytoplasmic Pool of Flagellins at the Level of Translation Initiation, Secretion, and Proteolysis [0.03%]
伯氏疏螺旋体鞭毛素特异分子伴侣FliS通过翻译起始、分泌和蛋白酶解控制细胞内鞭毛素的浓度
Ching Wooen Sze,Kai Zhang,Michael J Lynch et al.
Ching Wooen Sze et al.
The flagellin-specific chaperone FliS has been studied in externally flagellated bacteria; however, its role in spirochetes, a group of bacteria that possess unique internalized flagella (termed endo- or periplasmic flagella), remains unexp...
Multi-Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance [0.03%]
多组学分析实验进化的C.auris分离株揭示了 acquired 两性霉素B抗性的甾醇、鞘脂和氧化应激的调节作用
Anshu Chauhan,Hans Carolus,Dimitrios Sofras et al.
Anshu Chauhan et al.
Clinical isolates of Candida auris show a high prevalence of resistance to Amphotericin B (AmB)-an uncommon trait in most Candida species. Alterations in ergosterol biosynthesis can contribute to acquired AmB resistance in C. auris laborato...
Pseudomonas syringae Socially Induced Swimming Motility Requires the Molybdenum Cofactor [0.03%]
钼辅因子是促进植物病原菌假单胞菌群体感应所必需的游泳运动伪基因系синингае的重要因子
Zichu Yang,Bryan Swingle
Zichu Yang
Social interactions among bacteria can induce behaviors that affect their fitness and influence how complex communities assemble. Here we report a new socially induced motility behavior that we refer to as baited expansion in Pseudomonas sy...
FlhG Cooperates With the Cell Cycle Regulator GpsB to Confine Peritrichous Flagella in B. subtilis [0.03%]
弗拉基亚基因产物FlhG与细胞周期调节因子GpsB合作将周生鞭毛限制在芽孢杆菌中
Anita Dornes,Patrica Bedrunka,Benjamin Pillet et al.
Anita Dornes et al.
Number and arrangement of flagella, the bacterial locomotion organelles, are species-specific and serve as key taxonomic markers. The FlhG ATPase (also: YlxH, FleN), along with FlhF, plays pivotal roles in determining flagellation patterns....
Genome-Wide Analysis of DtxR and HrrA Regulons Reveals Novel Targets and a High Level of Interconnectivity Between Iron and Heme Regulatory Networks in Corynebacterium glutamicum [0.03%]
全局基因组分析揭示出新的目标并显示出DtxR和HrrA调节子在谷氨酸棒杆菌中铁与血红素调控网络间具有高度的互连性
Aileen Krüger,Ulrike Weber,Julia Frunzke
Aileen Krüger
Iron is vital for most organisms, serving as a cofactor in enzymes, regulatory proteins, and respiratory cytochromes. In Corynebacterium glutamicum, iron and heme homeostasis are tightly interconnected and controlled by the global regulator...
Heterologous Surface Display Reveals Conserved Complement Inhibition and Functional Diversification of Borrelia burgdorferi Elp Proteins [0.03%]
异源表面展示揭示了Borrelia burgdorferi Elp蛋白保守的补体抑制和功能多样化
Nathan Hill,Lara M Matulina,Cameron MacIntyre et al.
Nathan Hill et al.
Lyme disease is a tick-borne spirochetosis with diverse clinical manifestations. Genotypic and phenotypic variation among Borrelia burgdorferi strains correlates with variable manifestations of Lyme disease in humans; this diversity is attr...
ModE Regulates Alternative Nitrogenase Expression in the Methanogen Methanosarcina acetivorans [0.03%]
调节甲烷生成菌中的异型氮酶表达
Melissa Chanderban,Daniel J Lessner
Melissa Chanderban
All methanogens that can fix nitrogen use molybdenum (Mo) nitrogenase. Some methanogens, including Methanosarcina acetivorans, also contain alternative vanadium- and iron-nitrogenases, encoded by the vnf and anf operons, respectively. These...
The Pxp Complex Detoxifies 5-Oxoproline and Promotes the Growth of Clostridioides difficile [0.03%]
Pxp复合物能够清除5-氧脯氨酸并促进艰难梭菌的生长
Cheyenne D Lee,Arshad Rizvi,Zavier A Carter et al.
Cheyenne D Lee et al.
Clostridioides difficile is an anaerobic enteric pathogen that disseminates in the environment as a dormant spore. For C. difficile and other sporulating bacteria, the initiation of sporulation is a regulated process that prevents spore for...
Luminal Phospholipase D Attacks Bacterial Membranes in Dictyostelium discoideum Phagosomes [0.03%]
Dictyostelium discoideum吞噬溶酶体内源磷脂酶D攻击细菌细胞膜
Otmane Lamrabet,Raphael Munoz-Ruiz,Imen Ayadi et al.
Otmane Lamrabet et al.
Phagocytic cells ingest bacteria and kill them in phagosomes. A variety of molecular mechanisms allow the killing and destruction of bacteria in phagosomes, but their complete list and relative importance remain poorly defined. Here we have...