The Role of torS and torT Transcription in Driving a Bet-Hedging Strategy for Trimethylamine N-Oxide Reductase Expression in Escherichia coli [0.03%]
torS和torT转录在驱动三甲胺N-氧还原酶表达的锦瑟决策策略中的作用
Erin L Mettert,Jeffrey N Carey,Wilma Ross et al.
Erin L Mettert et al.
In Escherichia coli, cell-to-cell variability in aerobic expression of trimethylamine N-oxide (TMAO) reductase serves as a bet-hedging strategy, enabling a subset of cells to continue growing upon a shift to anaerobic conditions in the pres...
The Master Regulator Spo0A Integrates DNA Sequence and Shape to Regulate the Sporulation Kinase Gene kinA in Bacillus subtilis [0.03%]
芽孢杆菌中的主调节因子Spo0A整合DNA序列和形状调控孢子生成激酶基因kinA表达
Syeda Hira Zahid,Brenda Zarazúa-Osorio,Renee Escobedo et al.
Syeda Hira Zahid et al.
Sporulation in starved Bacillus subtilis depends on precise control of kinA, which encodes the major phosphorelay kinase that generates the threshold level of phosphorylated Spo0A (Spo0A~P) required for entry into sporulation. Here, we defi...
Detection of Ring Structure and Its Flexibility in Periplasmic Region of FliL, Bacterial Flagellar Stator-Associate Protein, in Marine Vibrio [0.03%]
海洋弧菌鞭毛离子中与膜相关的FliL蛋白周质区的环结构及柔性研究
Tatsuro Nishikino,Norihiro Takekawa,Raymond Burton-Smith et al.
Tatsuro Nishikino et al.
FliL is a conserved single-transmembrane protein implicated in stator function and load adaptation of bacterial flagellar motors. We analyzed the oligomeric organization and structural plasticity of the periplasmic domain of polar-flagellum...
A Spontaneous Mutation in tfoX Impairs Bioluminescence in Photobacterium kishitanii ANT-2200 [0.03%]
tfoX的自发突变会损害天蓝色素杆菌ANT-2200的发光性
Capucine Le Cam Ligier,Gwenola Simon,Charlotte Berthelier et al.
Capucine Le Cam Ligier et al.
Bioluminescence in luminous Vibrionaceae is often regulated by quorum sensing, yet several Photobacterium strains emit light independently of cell density, suggesting alternative regulatory inputs. Here, we characterized DimLum, a spontaneo...
AP2XI-3 is Critical for the Cell Cycle of Toxoplasma to Progress Through the G1 Phase [0.03%]
AP2XI-3 对子孢子虫细胞周期通过G1期至关重要的作用
Fuqiang Fan,Xiaoyan Yin,Anqi Liu et al.
Fuqiang Fan et al.
Toxoplasmosis caused by the Apicomplexan parasite Toxoplasma gondii is a significant health threat to immunocompromised individuals and newborns. This parasite has a complex life cycle that is well controlled to achieve optimal transmission...
A Novel Plasmodium berghei Protein, LSMP, Regulates Malaria Liver Stage Maturation [0.03%]
新型等孢子球虫蛋白LSMP调控疟原虫肝阶段成熟化
Rohini Nandi,Akancha Mishra,Shabeer Ali et al.
Rohini Nandi et al.
Malaria parasites undergo extensive replication in hepatocytes before initiating the pathogenic blood stage of infection. Although this clinically silent phase is essential for parasite expansion, the molecular mechanisms regulating late li...
Divergent Autophagy Pathways in Plasmodium: Mechanisms, Functions, and Therapeutic Potential [0.03%]
疟原虫的发散性自噬途径：机制、功能及治疗潜力
Suryansh Rajput,Pragya Mehra,Rohini Nandi et al.
Suryansh Rajput et al.
Autophagy is a highly conserved degradative and recycling pathway essential for maintaining cellular homeostasis. Although its molecular machinery is well characterized in yeast and mammalian systems, it is less studied in the early-divergi...
A Nutrient-Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus [0.03%]
一种营养响应LuxR调节因子在Legionella属中协调效应基因表达
Chen Adler,Gil Segal
Chen Adler
Legionella pneumophila utilizes the Icm/Dot secretion system to translocate > 330 effectors into host cells, yet the regulatory mechanisms controlling the expression of many effector-encoding genes (EEGs) remain unknown. Here, we identify a...
The Synergy Between a Silver-Ruthenium Antimicrobial and Aminoglycosides Is Based on Severe Macromolecular Damage [0.03%]
银 ruthenium 抗微生物和氨基糖苷类之间的协同作用基于严重的大分子损伤
Emmanuel P Oladokun,Gracious Y Donkor,Julius K Narh et al.
Emmanuel P Oladokun et al.
The rise of multidrug-resistant (MDR) bacterial pathogens, including uropathogenic Escherichia coli (UPEC), highlights the urgent need for alternative treatment strategies to restore antibiotic efficacy. The silver-ruthenium antimicrobial A...
Elucidating the Staphylococcus aureus TSST-1 Regulatory Network as a Response to Vaginal pH [0.03%]
阐明金黄色葡萄球菌TSST-1调节网络对阴道pH变化的响应机制
Carla S Maduta,Nicholas R Walton,Emily P Barbosa et al.
Carla S Maduta et al.
Menstrual toxic shock syndrome (mTSS) is a life-threatening disease caused by the Staphylococcus aureus superantigen TSST-1. At menstruation, the typical acidic vaginal environment rises to near neutral pH, which allows for enhanced TSST-1 ...