Hong-Liang Xiao,Si-Ting Li,Ting-Ting Li et al.
Hong-Liang Xiao et al.
Diazepam (DZP) residues in aquaculture environments pose a serious threat to food safety. To investigate the pharmacokinetics and residue elimination patterns of DZP using zebrafish as a model organism, a pharmacokinetic study, zebrafish we...
Effect of Different Top-Coating Materials on Minimizing Drug Leaching From Medicated Feed in Shrimp Aquaculture [0.03%]
不同外涂层材料对虾养殖药饵中药物溶出的缓释效果研究
Niti Chuchird,Jenjiraporn Hantrathin,Phongchate Pichitkul et al.
Niti Chuchird et al.
Drug leaching from medicated feeds into water reduces the available drug for absorption in the gut and causes negative effects in environments. The objectives of this study were to evaluate various top-coating materials in reducing the leac...
Functional Characterization of the Cat and Dog Wild-Type and Mutant MDR1 Carrier Proteins and Frequency of the MDR1 Gene Mutation in 800 Cats From Germany [0.03%]
德国800只猫的野生型和突变型MDR1转运蛋白的功能表征及其多药耐药基因突变频率研究
Lisa Siegl,Mies Bethäuser,Daniela Nürnberger et al.
Lisa Siegl et al.
The ATP-binding cassette transporter MDR1 P-glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood-brain barrier, MDR1 restricts brain entry of potenti...
Development of Machine Learning and Chemical Language Model-Based QSAR Models for Predicting Drug Residue Depletion Half-Lives in Plasma and Tissues of Cattle Across Various Administration Routes [0.03%]
基于机器学习和化学语言模型的QSAR建模方法预测牛体内不同给药途径下药物残留消除半衰期分布规律
Zhicheng Zhang,Lisa A Tell,Zhoumeng Lin
Zhicheng Zhang
Accurate prediction of drug depletion half-lives plays a pivotal role in determining extralabel withdrawal intervals and ensuring the safety of food products derived from livestock. In this study, we employed machine learning (ML)-based qua...
Pharmacokinetics of Some Synthetic Triazine Anticoccidials in Apparently Healthy North Island Brown Kiwi (Apteryx mantelli) Chicks [0.03%]
几种合成三嗪类抗球虫药在外观健康的北地布朗 kiwi（ Apteryx mantelli）雏鸟体内的药动学研究
Emma Scheltema,Preet Singh,Laryssa Howe et al.
Emma Scheltema et al.
Captive-reared kiwi (Apteryx spp.) chicks commonly suffer from coccidiosis, a parasitic disease that can cause morbidity and mortality in young immune-naive birds. Disease is currently managed in captivity through a combination of preventat...
Pharmacokinetics and Safety of a Single Subcutaneous or Intramuscular Dose of Ketamine in Healthy Horses [0.03%]
单剂量氯胺酮皮下或肌内注射在健康马上的药动学和安全性研究
Ana Rangel,Debra C Sellon,Macarena G Sanz et al.
Ana Rangel et al.
Pharmacokinetics (PK) of intramuscular (IM) and subcutaneous (SC) ketamine in horses has not been described. This study aimed to evaluate the PK and safety of ketamine and its metabolites after a single SC or IM administration. In Phase 1, ...
Pharmacokinetic Parameters of Oral Firocoxib, Oral Meloxicam, and Transdermal Flunixin in Meat Type Goats [0.03%]
肉用山羊口服菲洛coxib、口服美洛昔康和透皮氟尼辛的药动学参数
Mikaela M Weeder,Michael D Kleinhenz,Christopher T Culbertson et al.
Mikaela M Weeder et al.
The objective of this study was to determine and compare the pharmacokinetics of oral firocoxib, oral meloxicam, and transdermal flunixin (TD) in 44 adult, male castrated, crossbred goats. Pharmacokinetic (PK) analysis was performed for eac...
Pharmacokinetic Evaluation of Buserelin Acetate (Receptal) in Gilts [0.03%]
布舍立坦（瑞ceptal）在母猪体内的药代动力学评价
Preechaphon Taechamaeteekul,Tussapon Boonyarattanasoonthorn,Chutikan Srisang et al.
Preechaphon Taechamaeteekul et al.
Buserelin acetate, a synthetic analog of gonadotropin-releasing hormone (GnRH), is used to induce ovulation and enable fixed-time artificial insemination (FTAI) in swine. Evaluating the pharmacokinetics of buserelin acetate is crucial for o...
Comparison of Human and Canine P-Glycoprotein Substrates at R, P, and H Binding Sites [0.03%]
人和犬P-糖蛋白R、P和H结合位点底物的比较分析
Neal S Burke,Katrina L Mealey
Neal S Burke
P-glycoprotein (P-gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P-gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P-gp status of dr...
Optimizing the Dosage of Ceftiofur to Treat Porcine Respiratory Infection Based on a Population Pharmacokinetic Model and Monte Carlo Simulation [0.03%]
基于人群药代动力学模型和蒙特卡罗模拟的治疗猪呼吸道感染的头孢噻呋剂量优化研究
Chengyang Zhang,Haiyan Liu,Ziyan Kou et al.
Chengyang Zhang et al.
Porcine respiratory diseases is a major cause of economic losses in livestock, and ceftiofur is one of the core therapeutic agents for its treatment, but the clinical efficacy can be inconsistent. Therefore, it is necessary to utilize a pop...