The Pharmacokinetics of Intravenous and Subcutaneous Ondansetron in Female Beagle Dogs [0.03%]
静脉和皮下注射昂丹司琼在雌性比格犬体内的药代动力学
Elena D Landau,Kendal R Boege,Kristen Messenger et al.
Elena D Landau et al.
The purpose of this study was to evaluate the pharmacokinetic profile of ondansetron following intravenous (IV) and subcutaneous (SC) administration in five healthy adult female Beagles. Dogs were administered ondansetron at 0.5 mg/kg IV an...
Ertapenem Pharmacokinetics in Equine Plasma and Synovial Fluid Following a Single Intravenous Dose [0.03%]
一次静脉给药后厄他培南在马血浆和滑膜液中的药动学特征
Alexa R Bish-Jones,Mark G Papich,James A Orsini
Alexa R Bish-Jones
This study describes the pharmacokinetics of ertapenem, a carbapenem antimicrobial that has not been previously studied in equids. Administered as a 30 mg/kg intravenous bolus to six healthy horses, serial blood and synovial samples were ob...
Effectiveness of Cranberry Supplementation for Prevention and Treatment of Infectious Urinary Tract Disease in Dogs and Cats: A Systematic Review [0.03%]
蔓越莓补充剂预防和治疗犬猫感染性泌尿道疾病的有效性：系统综述
J Scott Weese,Heather E Weese
J Scott Weese
Cranberry and cranberry extracts are available for treatment or prevention of urinary tract disease in dogs and cats, but guidance regarding their use is lacking. The objectives were to identify and assess literature pertaining to the effic...
Pharmacokinetics and Anti-Inflammatory Effects of Intramuscular Betamethasone in Exercised Thoroughbred Horses [0.03%]
用于运动后赛马的肌肉注射倍他米松的药代动力学和抗炎作用
Juliana Sullivan,Jeff Blea,Daniel S McKemie et al.
Juliana Sullivan et al.
The pharmacokinetics and pharmacodynamics of betamethasone following intra-articular administration to horses have been described; however, studies characterizing intramuscular administration are lacking. Twenty-four horses received an intr...
Exposure to Subcutaneously Administered Butorphanol in Horses Pre-Treated With Detomidine or Detomidine-Vatinoxan [0.03%]
美洛昔康预处理的马皮下注射布托啡诺的暴露量
Juhana M Honkavaara,Ninja P Karikoski,Laura Palvas et al.
Juhana M Honkavaara et al.
The aim of the study was to determine the exposure to subcutaneously administered butorphanol in horses pre-treated with intravenous (IV) detomidine, with or without vatinoxan, a peripherally selective alpha2-adrenoceptor antagonist. Five h...
Pharmacokinetics, Optimal Dosages, and Withdrawal Time of Florfenicol in Cobia (Rachycentron canadum) After Oral Administration via Medicated Feed [0.03%]
口服氟苯尼考给药后药动学、最佳剂量和停药期的确定——以 cobia（拉氏鱥）为对象的研究
Jou-An Shih,Tirawat Rairat,Yi-Ping Lu et al.
Jou-An Shih et al.
Antimicrobial drugs are commonly used for the treatment of bacterial diseases in cobia (Rachycentron canadum), but information regarding the rationale of their therapeutic use, such as pharmacokinetics (PK), optimal dosages, and withdrawal ...
Pharmacokinetics of Intragastric Ursodeoxycholic Acid and Its Impact on Bile Acid Profiles in Horses [0.03%]
口服鹅去氧胆酸的药动学及其对马胆汁酸谱的影响
Amanda Macias,Barbara Delvescovo,Sam F Donaldson et al.
Amanda Macias et al.
Ursodeoxycholic acid (UDCA), a secondary bile acid (BA) with therapeutic applications, is standard therapy for cholestatic hepatopathies in humans. In recent years, its use has been increasingly explored in equine medicine for similar indic...
Single-Dose Pharmacokinetics of Intranasal Levetiracetam in Healthy Dogs [0.03%]
健康犬单剂量鼻内给药利培酮的药动学研究
Jessica L Wagner,Kari D Foss,Jennifer M Reinhart et al.
Jessica L Wagner et al.
Cluster seizures and status epilepticus in dogs are emergencies requiring rapid intervention. Intranasal (IN) benzodiazepines are effective for early seizure cessation, but the pharmacokinetics of longer-acting antiseizure medications admin...
Pharmacokinetics and Tissue Residue Profiles of Enrofloxacin in Nile Tilapia Oreochromis niloticus Following a Single Oral Administration [0.03%]
口服恩诺沙星在尼罗罗非鱼体内的药代动力学及组织残留规律
Thangapalam Jawahar Abraham,Ratnapriya Das,Arya Sen et al.
Thangapalam Jawahar Abraham et al.
The increasing frequency of bacterial diseases in aquaculture has necessitated the use of several antibiotics, including enrofloxacin (ENF), a broad-spectrum fluoroquinolone. The pharmacokinetic (PK) and pharmacodynamic (PD) data on ENF und...
Comparative Pharmacokinetics of Intranasal or Intramuscular Atipamezole in Unsedated Dogs and Efficacy for Reversal of Xylazine Sedation [0.03%]
关于对非镇静犬鼻内或肌肉注射阿替帕唑的比较药代动力学及其逆转十字莱因为止痛而造成的镇静的有效性研究
Vanessa E Cowan,Vanessa R McCrae,Deborah L Michel et al.
Vanessa E Cowan et al.
The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study ...