The pharmacokinetics of dexmedetomidine administered as a constant rate infusion in horses [0.03%]
右美托咪定恒速静脉输注在马体内的药动学研究
B Ranheim,Å I Risberg,C Spadavecchia et al.
B Ranheim et al.
Dexmedetomidine, the most selective α2-adrenoceptor agonist in clinical use, is increasingly being used in both conscious and anaesthetized horses; however, the pharmacokinetics and sedative effects of this drug administered alone as an in...
Pharmacokinetics of amoxicillin trihydrate in cultured olive flounder (Paralichthys olivaceus) [0.03%]
三氢氯唑西林在养殖 Olive flounder (Paralichthys olivaceus)体内的药动学研究
J S Seo,E J Jeon,S H Jung et al.
J S Seo et al.
The study was aimed at investigating the pharmacokinetics of amoxicillin trihydrate (AMOX) in olive flounder (Paralichthys olivaceus) following oral, intramuscular, and intravenous administration, using high-performance liquid chromatograph...
Randomized Controlled Trial
Journal of veterinary pharmacology and therapeutics. 2015 Feb;38(1):86-92. DOI:10.1111/jvp.12155 2015
Detection and pharmacokinetics of salbutamol in thoroughbred racehorses following inhaled administration [0.03%]
inhaled沙丁胺醇在赛马体内的代谢动态研究
M E Wieder,S W Paine,P R Hincks et al.
M E Wieder et al.
Salbutamol sulphate (Ventolin Evohaler) was administrated via the inhalation route to six horses at a dose of 0.5 mg every 4 h during the day for 2 days (total dose 4 mg). Urine and blood samples were taken up to 92 h postadministration. Hy...
Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs [0.03%]
正常狗模型中呋塞米激活肾素血管紧张素醛固酮系统后苯拉普利对醛固酮的抑制作用研究
A C Lantis,M K Ames,C E Atkins et al.
A C Lantis et al.
Pilot studies in our laboratory revealed that furosemide-induced renin-angiotensin-aldosterone system (RAAS) activation was not attenuated by the subsequent co-administration of benazepril. This study was designed to evaluate the effect of ...
Physicochemical characterization and pharmacokinetics in broiler chickens of a new recrystallized enrofloxacin hydrochloride dihydrate [0.03%]
一种新型结晶恩诺沙星盐酸二水合物的理化性质表征及其在肉鸡体内的药动学研究
L Gutierrez,J E Miranda-Calderon,P Garcia-Gutierrez et al.
L Gutierrez et al.
Enrofloxacin, a key antimicrobial agent in commercial avian medicine, has limited bioavailability (60%). This prompted its chemical manipulation to yield a new solvate-recrystallized enrofloxacin hydrochloride dihydrate entity (enroC ). Its...
Pharmacokinetics of danofloxacin and N-desmethyldanofloxacin in adult horses and their concentration in synovial fluid [0.03%]
达诺氟沙星及其代谢物在成年马体内的药代动力学及关节液中药物浓度测定
B S Lopez,S Giguère,L J Berghaus et al.
B S Lopez et al.
The objectives of this study were to investigate the pharmacokinetics of danofloxacin and its metabolite N-desmethyldanofloxacin and to determine their concentrations in synovial fluid after administration by the intravenous, intramuscular ...
Brain penetration of emodepside is increased in P-glycoprotein-deficient mice and leads to neurotoxicosis [0.03%]
艾莫德普西啶穿透无P-糖蛋白的小鼠大脑并导致神经毒性反应
S Elmshäuser,L C Straehle,J Kranz et al.
S Elmshäuser et al.
The antiparasitic drug emodepside (EMO) is a substrate of the P-glycoprotein multidrug efflux carrier (P-gp; syn. MDR1, ABCB1), which has an important function in protecting the brain from potentially toxic compounds by functional drug effl...
Prostaglandin E2 as a read out for endotoxin detection in a bovine whole blood assay [0.03%]
牛全血试验中以前列腺素E2反映内毒素检测结果的能力
C Wunderlich,S Schumacher,M Kietzmann
C Wunderlich
The detection of endotoxin contamination is an essential part of drug safety testing. The rabbit pyrogen test (RPT), the limulus amoebocyte lysate (LAL) test, and the monocyte activation test (MAT) are established methods for the detection ...
Pharmacokinetic modeling and Monte Carlo simulation of ondansetron following oral administration in dogs [0.03%]
口服奥丹司琼在狗体内的药代动力学 modelling 和 Monte Carlo 模拟
I-H Baek,B-Y Lee,J Kang et al.
I-H Baek et al.
Ondansetron is a potent antiemetic drug that has been commonly used to treat acute and chemotherapy-induced nausea and vomiting (CINV) in dogs. The aim of this study was to perform a pharmacokinetic analysis of ondansetron in dogs following...
Endogenous concentrations, pharmacokinetics, and selected pharmacodynamic effects of a single dose of exogenous GABA in horses [0.03%]
马单剂量外源性γ-氨基丁酸的内源性浓度、药代动力学和选定药效学效应
H K Knych,S J Steinmetz,D S McKemie
H K Knych
The anti-anxiety and calming effects following activation of the GABA receptor have been exploited in performance horses by administering products containing GABA. The primary goal of the study reported here was to describe endogenous conce...