Artificial intelligence in the diagnosis of gastro-entero-pancreatic neuroendocrine neoplasms: Potential benefits and current limitations [0.03%]
人工智能在胃肠道胰神经内分泌肿瘤诊断中的潜在益处和当前局限性
Elettra Merola,Giuseppe Fanciulli,Giovanni Mario Pes et al.
Elettra Merola et al.
Neuroendocrine neoplasms (NENs), once considered rare, are now increasingly diagnosed worldwide, with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) accounting for the majority of cases (55%-70%). NENs are characterized by consid...
Comparative analysis of androgen and estrogen receptor mRNA expression in adult mouse hippocampus [0.03%]
雄激素受体和雌激素受体mRNA在成年鼠海马区的表达比较分析
Malte Schöbe,Bianka Brunne,Roland A Bender
Malte Schöbe
In hippocampus, androgens and estrogens influence neuronal plasticity via a range of nuclear or membrane-bound receptors. While much work has focused on determining their functions, a certain vagueness about the cellular expression of estab...
Corticotropin-releasing factor type 1 receptors in the rat nodose ganglion are involved in the transduction of stress-induced visceral sensory signals to the brain [0.03%]
下神经节中促肾上腺皮质激素释放因子受体在应激诱导的内脏感觉信号向脑的传递中的作用
Asuka Mano-Otagiri,Tamotsu Shibasaki,Atsushi Sakai et al.
Asuka Mano-Otagiri et al.
Corticotropin-releasing factor (CRF) plays roles in stress-related responses through its type 1 (CRF1) and type 2 receptors. Both CRF and CRF1 are expressed in the rat colon. Peripheral CRF administration and various stressors increase colo...
Intraoperative hepatic ultrasonography in patients with gastrointestinal and pancreatic neuroendocrine neoplasms without preoperative evidence of liver metastases [0.03%]
无术前肝转移证据的胃肠胰神经内分泌肿瘤患者术中肝脏超声检查
L Viganò,M Maruccio,F Faustini et al.
L Viganò et al.
In patients with gastroenteric and pancreatic neuroendocrine neoplasms (GEP-NENs), the risk of liver metastases is high, but the accuracy of standard imaging for detecting small hepatic nodules is limited. This raises concerns about the ade...
Single-cell transcriptomic analysis reveals a metastasis-associated PCSK1+ neuroendocrine subpopulation in pancreatic neuroendocrine tumors [0.03%]
单细胞转录组分析揭示了胰腺神经内分泌肿瘤中与转移相关的PCSK1+神经内分泌亚群
Xiaolei Yin,Xiaopeng Li,Lili Mi et al.
Xiaolei Yin et al.
Pancreatic neuroendocrine tumors (PNETs) are uncommon malignancies characterized by significant clinical heterogeneity and a pronounced tendency for liver metastasis. Despite this, the cellular mechanisms driving PNET progression remain ina...
Association rule mining of clinical and biomarker data in neuroendocrine tumors: A prospective study on disease progression [0.03%]
神经内分泌肿瘤临床和生物标志物数据的关联规则挖掘：一项关于疾病进展的前瞻性研究
Ulrich Peter Knigge,Magnus Kjellman,Henning Grønbæk et al.
Ulrich Peter Knigge et al.
There is an unmet need for new methods to predict disease course in patients with neuroendocrine tumors (NET). We investigated 92 putative cancer-related plasma proteins including chromogranin A (CgA) and clinical parameters at the time of ...
Quality of life as a predictor for survival in patients with small intestinal neuroendocrine tumours [0.03%]
生活质量作为小肠神经内分泌肿瘤患者生存预测因素的影响
Håkan Ohlsson,Martin Nilsson,Anna Sundlöv et al.
Håkan Ohlsson et al.
Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survi...
Tumor-infiltrating immune cells predict the response to somatostatin receptor ligands only in somatotropinomas naïve to medical therapy [0.03%]
肿瘤浸润性免疫细胞仅在未接受过药物治疗的生长激素腺瘤中预测生长抑素受体配体的疗效
Sabrina Chiloiro,Alessandra Vicari,Antonella Giampietro et al.
Sabrina Chiloiro et al.
Tumor-infiltrating immune cells (TICs) are important components of the tumor microenvironment (TME). They regulate somatotroph adenoma treatment responses to therapy with somatostatin receptor ligands (SRLs), mediated by soluble factors and...
Melatonin receptors and thyroid stimulating hormone in the equine pars tuberalis: Potential modulators of seasonal reproduction in the mare [0.03%]
马的松果体柄部褪黑素受体和促甲状腺激素：潜在的季节性生殖调节因子
Victoria N Bailey,Bryce M Gilbert,Michelle Vetter et al.
Victoria N Bailey et al.
The mechanism by which photoperiod influences the hypothalamic-pituitary-gonadal (HPG) axis and regulates seasonal reproduction in horses has yet to be fully elucidated. The hypophyseal pars tuberalis (PT) has been indicated as a critical s...
Controversies in NEN: An ENETS position statement on the treatment of patients with Grade 3 well-differentiated neuroendocrine tumours of the gastro-enteropancreatic tract [0.03%]
关于胃肠胰神经内分泌肿瘤治疗的争议：对三级分化良好神经内分泌肿瘤患者治疗的ENETS立场文件
Mairéad G McNamara,Halfdan Sorbye,Nehara Begum et al.
Mairéad G McNamara et al.
Grade 3 neuroendocrine tumours (NET G3) represent approximately 20% of high-grade neuroendocrine neoplasms, and the recent identification of this entity has given rise to many unanswered questions relating to clinical management. The progno...