Effects of gonadectomy on brain sex hormone levels and amyloid pathology in male and female AppNL-G-F and AppNL-F mice [0.03%]
卵巢和睾丸切除对雄性和雌性APPNL-G-F和APPNL-F小鼠脑内性激素水平及淀粉样病理的影响
Patricia Muñoz,Heba G Ali,Aphrodite Demetriou et al.
Patricia Muñoz et al.
More women than men are diagnosed with Alzheimer's disease (AD). Sex hormones have been ascribed neuroprotective properties, and their decline, particularly the reduction of estrogen during menopause, has been implicated in AD risk. In this...
Profile of gonadotropin secretion in male and female rats determined in the tail-tip blood by ultrasensitive ELISA [0.03%]
超敏感ELISA法测定大鼠尾血促性腺激素的昼夜分泌模式及其性别差异
Roberta Araujo-Lopes,Andre F Gomes,Matheus Viana et al.
Roberta Araujo-Lopes et al.
There is a need for accurate and less invasive methods of hormonal measurements. Here, we longitudinally determined luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion measured in the tail-tip blood of male and female ...
Oxytocin supports the barrier integrity of brain endothelial cells via oxytocin receptors [0.03%]
催产素通过催产素受体维持脑内皮细胞屏障的完整性
Camilla Paolini,Francesca Piacentini,Sarah Amato et al.
Camilla Paolini et al.
Oxytocin plays an emerging role in vascular regulation and neuroprotection, but its effect on brain endothelial cells and blood-brain barrier functionality is not fully defined. To assess oxytocin and vasopressin receptor expression in brai...
Proteomic insights into the invasiveness and tumor progression of non-functioning pituitary adenomas: A scoping review [0.03%]
非功能性垂体腺瘤侵袭性和肿瘤进展的蛋白质组学见解：系统综述
Thomas Skoglund,Linus Köster,Annika Thorsell et al.
Thomas Skoglund et al.
Nonfunctioning pituitary adenomas (NFPAs) are common intracranial tumors that, despite being histologically benign, can exhibit invasive growth, as well as postoperative tumor progression. Surgical resection is the primary treatment of choi...
Biomarkers of hypothalamic melanocortin activity in human energy balance [0.03%]
人能量平衡中下丘脑黑素皮质激素活性的生物标志物
Sharon L Wardlaw,Richard M Smiley
Sharon L Wardlaw
The hypothalamic melanocortin system, comprised of proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, regulates energy balance but studies in humans are limited by lack of biomarkers to assess brain melanocortin activity....
Effects of combined prenatal exposure to air pollution and maternal stress on social behavior and oxytocin and vasopressin systems in male and female mice [0.03%]
空气污染和母体压力联合暴露对小鼠社会行为及催产素和血管加压素系统的影响
Maura C Stoehr,Elise M Martin,Joy T Babalola et al.
Maura C Stoehr et al.
Prenatal exposures to air pollution and maternal psychosocial stress are each associated with increased risk of neurodevelopmental disorders, including autism spectrum disorder (ASD), and epidemiological work suggests that concurrent exposu...
Charles W Bourque,Alastair V Ferguson,Jack H Jhamandas et al.
Charles W Bourque et al.
Low-dose testosterone administration and oestrogen synthase availability in the female brain: A pilot study [0.03%]
低剂量睾丸激素补充和雌脑中合成酶的可用性：一项初步研究
Manon Dubol,My Jonasson,Kayo Takahashi et al.
Manon Dubol et al.
Testosterone and oestrogens play significant roles in female physiology, extending beyond reproductive functions to influence brain health, mood regulation, and behaviour. Testosterone low-dose therapy is increasingly considered for allevia...
Finasteride withdrawal induces anxiety-like behavior and novelty avoidance in adult male rats [0.03%]
非那雄胺戒断可诱发成年大鼠类似焦虑的行为及对新异环境的回避反应
Lucia Cioffi,Silvia Diviccaro,Gabriela Chrostek et al.
Lucia Cioffi et al.
Finasteride, an inhibitor of the enzyme 5alpha-reductase, prescribed for benign prostatic hyperplasia and androgenetic alopecia, induces a wide variety of side effects during treatment and upon withdrawal, like sexual dysfunction and cognit...