Systematic review and meta-analysis of the efficacy and safety of [177Lu]Lu-edotreotide ([177Lu]Lu-DOTATOC) for the treatment of neuroendocrine tumors [0.03%]
镥-177乙基苯基生长抑素类似物治疗神经内分泌肿瘤疗效和安全性的系统评价和 meta 分析
Richard P Baum,Julia G Fricke,Tristan Ruhwedel et al.
Richard P Baum et al.
[177Lu]Lu-edotreotide is a radiopharmaceutical therapy (RPT) targeting somatostatin receptors, which are commonly overexpressed on neuroendocrine tumors (NETs). This systematic literature review and meta-analysis describes the efficacy and ...
Stress-induced hyperphagia? Characterising the activity of the ghrelin axis in male rats with high anxiety behaviour [0.03%]
应激性过度饮食？高焦虑行为雄性大鼠胃泌素轴的活性研究
Amanda K E Hornsby,Bradley Haywood-Sheldrake,Katharina Gryksa et al.
Amanda K E Hornsby et al.
While evidence is emerging that the temporal pattern of feeding may influence anxiety, it is unclear to what extent anxiety may itself impact spontaneous feeding behaviour. To address this, we have quantified spontaneous feeding, ghrelin se...
Acute V1b vasopressin receptor antagonism ameliorates cardiovascular parameters in ovariectomized female rats subjected to chronic mild unpredictable stress [0.03%]
急性V1b血管加压素受体拮抗剂改善慢性温和不可预测应激去卵巢大鼠心血管参数
Sharif Hasan Siddiqui,Dragana Komnenov,Afoluso Olayonwa et al.
Sharif Hasan Siddiqui et al.
Depression is a recognized non-traditional risk factor for adverse cardiovascular disease (CVD) outcomes. The risk for CVD increases in women after menopause. The chronic mild unpredictable stress (CMS) paradigm is a validated rodent model ...
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction [0.03%]
食物与大脑：摄食、代谢和繁殖的神经和内分泌调节
Naira da Silva Mansano,Calvin Vinh Lieu,Alfonso Abizaid
Naira da Silva Mansano
Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems th...
The p75 neurotrophin receptor is expressed in brain regions mastering reproduction but not in kisspeptin or GnRH neurons [0.03%]
p75神经营养素受体在控制生殖的脑区表达但不在吻肽或GnRH神经元中表达
Flavie Derouin-Tochon,Vincent Robert,Didier Lomet et al.
Flavie Derouin-Tochon et al.
Neurotrophins (BDNF, NGF, NT3, and NT4/5) acting through different receptors are able to impact numerous functions, including cell fate and morphological plasticity, an asset for the maturation and differentiation of cells from neurogenic n...
Optogenetic stimulation of the median preoptic nucleus: Effects on hypothalamic paraventricular nucleus magnocellular neurons after chronic intermittent hypoxia exposure [0.03%]
中缝核视黄酸能神经元对慢性间歇性缺氧大鼠PVN室管膜细胞源性胰岛素信号的影响
Obed T Paundralingga,Shuping Jia,George E Farmer Jr et al.
Obed T Paundralingga et al.
Median preoptic nucleus (MnPO) neurons projecting to the hypothalamic paraventricular nucleus (PVN) are linked to hypertension induced by chronic intermittent hypoxia (CIH), a model of obstructive sleep apnea. The modulation of MnPO-driven ...
Chronic circadian disruption in female mice induces a long-term alteration of the preovulatory LH surge [0.03%]
在小鼠中慢性昼夜节律紊乱引起长期的排卵前LH峰值变化
Marine Simonneaux,Valérie Simonneaux
Marine Simonneaux
In female mammals, many aspects of the reproductive function require precise synchronization of neuroendocrine and behavioral events for optimal fertility. To this end, the circadian timing system entrained by light exposure, in addition to...
A male-dominant cell group expressing calbindin-D28K and androgen receptor in the mouse preoptic area requires postnatal testicular androgens and histone deacetylation [0.03%]
雄激素和组蛋白去乙酰化依赖的新生鼠下视丘前核钙结合蛋白神经元表型分化及其机制研究
Yusa Arai,Shinji Tsukahara
Yusa Arai
The mouse brain is masculinized by postnatal testicular androgens, which are active after conversion to estrogens and modulate gene expression epigenetically, at least in part. The preoptic area contains a sexually dimorphic nucleus (SDN) c...
GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice [0.03%]
雄性小鼠嗅球中的GHSR抑制摄食动机并促进探索而不改变空间记忆
Romana Stark,Jeffrey M Zigman,Zane B Andrews
Romana Stark
The olfactory bulb (OB) is an emerging neuroendocrine centre regulating appetite, metabolism, and behaviours such as those linked to anxiety, motivation and spatial navigation. These processes are likely mediated by one or more of the many ...
Dopamine and prolactin in migraine: Mechanisms and potential therapeutic targets [0.03%]
多巴胺和催乳素在偏头痛中的机制及潜在治疗靶点
Astrid Johannesson Hjelholt,Randi Maria Hanghøj Tei,Hans Christoph Diener et al.
Astrid Johannesson Hjelholt et al.
Migraine is a complex neurovascular disorder characterized by activation and sensitization of the trigeminovascular system. Hyperprolactinemia is associated with headache, and improvement following prolactin-lowering therapy has been report...