Karl J Iremonger
Karl J Iremonger
Hypothalamic neuroendocrine neurons control diverse homeostatic functions that are essential for survival. While the cell bodies of these neurons are widely distributed, the nerve terminals converge on one specialised area of the brain call...
The gatekeepers of growth: The neural roles and regulation of growth hormone-releasing hormone neurons [0.03%]
生长的守门者：生长激素释放激素神经元的神经作用和调节
Bradley B Jamieson
Bradley B Jamieson
The neuroendocrine control of growth is mediated by the hypothalamic-pituitary-somatic (HPS) axis. This involves the hypothalamic release of growth hormone-releasing hormone (GHRH), which stimulates the pituitary secretion of growth hormone...
Non-synaptically released oxytocin regulates social communication by acting on vasopressin V1a receptors [0.03%]
催产素通过作用于血管加压素V1a受体调节非突触介导的社会交流行为
Dario Aspesi,James C Walton,Zachary A Grieb et al.
Dario Aspesi et al.
How neuropeptides act within the neural circuits that control social behavior is not well understood. While the prevailing view is that neuropeptides act through synaptic release and then activation of their canonical receptors on postsynap...
Magnetic resonance imaging features of hypophysitis in patients with cancer treated with immune checkpoint inhibitors [0.03%]
免疫检查点抑制剂治疗的癌症患者的垂体炎的磁共振影像学特点分析
Anna Angelousi,Stavroula Asimakopoulou,Charis Bourgioti et al.
Anna Angelousi et al.
Immune checkpoint inhibitors (ICIs) have significantly improved outcomes in several solid malignancies but are associated with endocrine immune-related adverse events (irAEs), particularly hypophysitis. This retrospective real-world data st...
From eyes to brain: A genetic and imaging exploration of thyroid eye disease neurological effects [0.03%]
从眼睛到大脑：甲状腺眼病神经影像及遗传学研究进展
Jiaqi Yao,Xinjian Lu,Jingxu Ma et al.
Jiaqi Yao et al.
Observational studies have reported that thyroid eye disease (TED) may cause structural and functional disorders in the brain, However, it remains uncertain whether this relationship is causal. Genetic data were obtained from the Finn Gen R...
Somatostatin analogs in neuroendocrine tumors with Ki-67 index of ≥10 [0.03%]
Ki-67指数≥10%的神经内分泌肿瘤的生长抑素类似物治疗
Johanna Braegelmann,Annie Mathew,Boerge Schmidt et al.
Johanna Braegelmann et al.
Somatostatin analogs (SSAs) are an established first-line therapy in intestinal and pancreatic neuroendocrine tumors (NETs). Based on Phase III studies, their use is recommended in NET with a Ki-67 index of up to 10%. The effect of first-li...
Unraveling the impact of oxytocin receptor gene methylation on stress and inflammation in older adults [0.03%]
解开血管加压素受体基因甲基化对老年人压力和炎症影响的谜团
Kylie A Wright,Rebecca J Polk,Tian Lin et al.
Kylie A Wright et al.
Oxytocin (OT) is a neuropeptide involved, among other functions, in the regulation of stress and inflammation. OT's impact on inflammatory and stress-related processes is particularly relevant in older adults, given that elevated levels of ...
Epidemiology of acquired hypothalamic obesity following traumatic brain injury and nonspecific hypothalamic microinjury: A nationwide German claims data analysis [0.03%]
德国全国理赔数据分析获得的创伤性脑损伤和非特异性下丘脑微损伤后的获得性下丘脑肥胖症的流行病学分析
Julian Witte,Nicolas Touchot,Manuel Batram et al.
Julian Witte et al.
Acquired hypothalamic obesity (aHO) is characterized by rapid and persistent weight gain resulting from structural or functional damage to the hypothalamus, typically accompanied by neuroendocrine dysfunction. While aHO is well described in...
The adverse effect of a hypercaloric high-fat diet feeding on hypothalamic cellular energy homeostasis is attenuated by a hypoglycemiant [0.03%]
一种降血糖药物可减轻高脂饮食对下丘脑细胞能量稳态的不利影响
Ariel Vivero,Sofía Espinoza,Javiera Álvarez-Indo et al.
Ariel Vivero et al.
Obesity is a global public health challenge emerging from an energy homeostasis (EO) disruption. EO is primarily driven by neurons residing in the hypothalamus, whose function is critical to integrate neural and humoral signals that account...
The relationship between dose, concentration and toxicity of everolimus in the treatment of neuroendocrine tumors: A prospective observational study [0.03%]
一项关于依维莫司治疗神经内分泌肿瘤的剂量、浓度和毒性的前瞻性观察研究
Oddry Henriette Folkestad,Jon Sponheim,Tone Lise Åvitsland et al.
Oddry Henriette Folkestad et al.
Everolimus is used in the treatment of patients with advanced neuroendocrine tumors (NET) and is administered at fixed doses despite known interpatient pharmacokinetic variability. This may affect both efficacy and tolerability. We wanted t...