The role of hypothalamic kisspeptin neurons in coordinating reproduction and metabolism [0.03%]
下丘脑亲吻肽神经元在协调生殖和代谢中的作用
Oline K Rønnekleiv,Jian Qiu,Martin J Kelly
Oline K Rønnekleiv
The hypothalamic control of fertility is a quintessential homeostatic function. Given that reproduction is metabolically demanding, coordination between energy status and reproductive function is essential. Since GnRH neurons lack receptors...
Chronic hyperprolactinemia is associated with enhanced high-fat diet binge eating in female mice [0.03%]
慢性高催乳素血症与雌性小鼠高脂饮食暴食有关
María Paula Cornejo,Felicitas Lopez-Vicchi,Catalina de Winne et al.
María Paula Cornejo et al.
Prolactin is fundamental for pregnancy and lactation, and also has numerous metabolic roles including the stimulation of appetite. Mice with chronic hyperprolactinemia display increased food intake, enhanced expression of orexigenic genes i...
Conventional ambient temperature housing impacts central oxytocin levels in mice [0.03%]
传统的环境温度饲养影响小鼠中枢神经系统催产素水平
William M Kenkel,Miranda E Partie,Katelyn F Rogers et al.
William M Kenkel et al.
Neuroscience depends heavily on research done in mice (Mus musculus), yet the field has done little to address the chronic cold stress mice perpetually face during conventional "room temperature" housing (20°C-22°C). Contributions from ot...
Characterization of tyrosine hydroxylase- and non-tyrosine hydroxylase-immunoreactive sexually dimorphic oxytocin receptor-expressing neurons in the anteroventral periventricular nucleus of female mice [0.03%]
雌性小鼠前室周核中酪氨酸羟基酶和非酪氨酸羟基酶免疫反应性的催产素受体表达的性别二态性神经元的特征化研究
Armita A Govar,Bandana Ghimire,Katsuhiko Nishimori et al.
Armita A Govar et al.
Oxytocin is involved in the regulation of maternal behavior by binding to the oxytocin receptor (OXTR) in various parts of the brain. Our previous studies demonstrated that OXTRs are specifically expressed in the anteroventral periventricul...
Human growth hormone-induced mitotic maladaptation in podocytes and implications in diabetic kidney disease [0.03%]
生长激素引起的足细胞有丝分裂适应不良及在糖尿病肾病中的影响
Bharath Banoth,Sumathi Raviraj,Anil Kumar Pasupulati
Bharath Banoth
Diabetes is a significant risk factor for the development of diabetic kidney disease, and about 30% of people with type I diabetes mellitus will eventually develop end-stage kidney disease. Growth hormone (GH) and its mediator insulin-like ...
11C-Hydroxyephedrine PET/CT for preoperative surgical planning in large pheochromocytoma and paraganglioma [0.03%]
11C-羟基麻黄碱正电子发射断层扫描/计算机断层扫描用于巨大嗜铬细胞瘤和副神经节瘤术前手术规划
Achyut Ram Vyakaranam,Olov Norlén,Alina Akural et al.
Achyut Ram Vyakaranam et al.
Early detection of metastases and timely surgical intervention play a crucial role in the management of neuroendocrine tumors. In large-sized pheochromocytomas and sympathetic paragangliomas (PPGL), functional imaging with positron emission...
Kisspeptin and early pregnancy: Insights from animal models into hormonal regulation and miscarriage [0.03%]
亲吻肽与早期妊娠：来自动物模型的激素调节和流产的新见解
Caroline Decourt,Katie Heads
Caroline Decourt
Miscarriage, defined as spontaneous pregnancy loss before 20 weeks of gestation, affects 10-15% of pregnancies in women under 30, rising to over 50% in women over 45. Implantation failure and early placental dysfunction are major contributo...
Cardiac fibrosis induced by high-fat diet in ApoE-deficient male mice is exacerbated by genetic deletion of PACAP-PAC1 signaling [0.03%]
高脂饮食诱导的Apoe缺陷型雄性小鼠心脏纤维化会由于PACAP-PAC1信号转导通路基因缺失而加重
J M Schubart,M K H Schaefer,G A Bonaterra et al.
J M Schubart et al.
Cardiac fibrosis is characterized by an excessive accumulation of extracellular matrix proteins and occurs in a variety of cardiac diseases, such as the highly prevalent syndrome heart failure with preserved ejection fraction (HFpEF) and ot...
Intravenous kisspeptin 112-121 bolus does not acutely impact circulating vasopressin in humans [0.03%]
静脉注射吻肽112-121单剂不会急性影响循环抗利尿激素在人类体内的含量
Francesca Galbiati,Franziska Plessow,Lacey Plummer et al.
Francesca Galbiati et al.
Arginine-vasopressin (AVP) deficiency (AVP-D) is caused by hypothalamic-pituitary damage of vasopressinergic neurons leading to polyuria and polydipsia. Diagnostic tests for AVP-D are limited by low accuracy and/or tolerability. Kisspeptin ...
Bone metastases from neuroendocrine neoplasms: Results of an Italian nationwide survey of natural history and management [0.03%]
意大利全国范围内的神经内分泌肿瘤骨转移自然史和治疗状况调查结果
Nicola Fazio,Patrick Maisonneuve,Anna Maria Frezza et al.
Nicola Fazio et al.
Bone metastases (BMs) were reported in 10 BMs, mixed pattern (osteoblastic/osteolytic) versus osteoblastic, prior lung metastases and SREs were found to be significant poor prognosis factors. At multivariable analysis Ki-67 ≥55% versus ≤2...